2021, Number 1
<< Back Next >>
Rev Cuba Endoc 2021; 32 (1)
Current approach to asymptomatic peripheral arterial disease in people with diabetes mellitus
García GY, Guerra FL, Pi, AP, Estévez PA, Acosta CA, Barnés DJA
Language: Spanish
References: 55
Page: 1-22
PDF size: 688.32 Kb.
ABSTRACT
The growing diabetes epidemic demands the need to implement strategies for the identification of diabetic complications in early stages, when they are still in the preclinical stage. Peripheral arterial disease is one of them, with devastating consequences for the patient, the family, and society. Its frequency of occurrence increases with age and with the time of evolution of diabetes. Most of the patients are asymptomatic, which makes diagnosis difficult. In addition, due to the limitations of physical examination, complementary tests are required, always with noninvasive studies. The ankle-brachial pressure index is the main method for detecting it, but it is necessary to know its limitations in people with diabetes, in order to interpret the results correctly. Patients with asymptomatic peripheral arterial disease have a faster functional decline with the probability of progressing to more serious forms of the disease, such as critical ischemia and amputation, as well as a higher risk of ischemic cardiovascular events in other arterial territories and of mortality. Screening for asymptomatic peripheral arterial disease in people with diabetes would permit identifying patients who would benefit from more intensive interventions; therefore, it is strongly recommended nowadays. With this work, we intend to discuss the importance of screening for this complication in people with diabetes, as well as the current challenges for its detection and diagnosis.
REFERENCES
International Diabetes Federation (IDF) Atlas IDF. The global pictures. The IDF Diabetes Atlas. 9th. Ed. IDF. 2019[citado 22 may 2020]: p. 50, 51, 56 y 57. Disponible en: Disponible en: https://diabetesatlas.org/en/resources/
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387:1513-30. DOI: 10.1016/S0140-6736(16)00618-8
Marone EM, Cozzolino P, Ciampichini R, Chiodini V, Ferraresi R, Rinaldi LF, Mantovani LG, Cesana G. Peripheral arterial disease in diabetic patients: a long-term population-based study on occurrence, outcomes and cost. J Cardiovasc Surg (Torino). 2018;59(4):572-9. DOI: 10.23736/S0021-9509.18.10405-8
Prompers L, Huijberts M, Apelqvist J, Jude E, Piaggesi A, Bakker K, et al. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot Disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 2007;50:18-25. DOI: 10.1007/s00125-006-0491-1
Conte MS, Pomposelli FB, Clair DG, Geraghty PJ, McKinsey JF, Mills JL, et al. Society for Vascular Surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities: Management of asymptomatic disease and claudication. J Vasc Surg. 2015;61:2S-41S. DOI: 10.1016/j.jvs.2014.12.009
Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur H J. 2019;00:1-69. DOI: 10.1093/eurheartj/ehz486
Faglia E, Caravaggi C, Marchetti R. Screening for peripheral arterial disease by means of the ankle-brachial index in newly diagnosed Type 2 diabetic patients. Diabet Med. 2005;22:1310-4. DOI: 10.1111/j.1464-5491.2005.01612.x
Felício JS, Cavalcante C, Abdallah N, Resende FS, Nascimento de Lemos M, Corrêa RJM, et al. Ankle-brachial index and peripheral arterial disease: An evaluation including a type 2 diabetes mellitus drug-naïve patients cohort. Diab Vasc Dis Res. 2019;16(4):344-50. DOI: 10.1177/1479164119829385
Mancera J, Paniagua F, Martos I, Baca A, Ruiz S, Gonzalez P, et al. Enfermedad arterial periférica oculta en población diabética seguida en atención primaria. Clin Invest Arterioscl. 2010;22(4):154-61. DOI: 10.1016/j.arteri.2010.04.001
Mohammedi K, Woodward M, Hirakawa Y, Zoungas S, Colagiuri S, Hamet P, et al. Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE‑ON study. Cardiovasc Diabetol. 2016;15(1I):129-33. DOI: 10.1186/s12933-016-0446-x
Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000. Circulation. 2004;110:738-43. DOI: 10.1161/01.CIR.0000137913.26087.F0
Aguilera Lagos R, Díaz López EJ, Colman Juárez BZ, Carranza Pagoada RE, Padilla Meza JC, Cáceres Munguía GI. Enfermedad arterial periférica y diabetes mellitus de tipo 2 en atención Primaria. Rev Cubana Angiol Cir Vasc [Internet]. 2020 [citado 22 may 2020];21(2). Disponible en: Disponible en: http://www.revangiologia.sld.cu/index.php/ang/article/view/113
Kamil S, Sehested TSG, Carlson N, Houlind K, Lassen JF, Bang CN, et al. Diabetes and risk of peripheral artery disease in patients undergoing first-time coronary angiography between 2000 and 2012 - a nationwide study. BMC Cardiovasc Disorders. 2019; 19:234. DOI: 10.1186/s12872-019-1213-1
Pita Fernández S, Modroño-Freire MJ, Pértega-Díaz S, Herrera-Díaz L, Seoane-Pillado T, Paz-Solís A, et al. Validez del cuestionario de Edimburgo para el diagnóstico de arteriopatía periférica en pacientes con diabetes mellitus tipo 2. Endocrinol Diabetes Nutr. 2017;64(9):471-9. DOI: 10.1016/j.endinu.2017.06.005
Al-Delaimy WK, Merchant AT, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Effect of type 2 diabetes and its duration on the risk of peripheral arterial disease among men. Am J Med. 2004;116:236-40. DOI: 10.1016/j.amjmed.2003.09.038
Zander E, Heinke P, Reindel J, Kohnert KD, Kairies U, Braun J, et al. Peripheral arterial disease in diabetes mellitus type 1 and type 2: are there different risk factors? Vasa. 2002;31:249-54. DOI: 10.1024/0301-1526.31.4.249
Rivero FE, Escalante O, Rivero T, Morales N, Lazo I. Rol de los factores de riesgo mayores en la macroangiopatía diabética de miembros inferiores. Rev Cubana Angiol Cir Vasc[Internet]. 2002 [citado 22 Oct 2019];3:24-9. Disponible en: Disponible en: http://bvs.sld.cu/revistas/ang/vol3_2_02/ang04202.htm
Llanes JA, Fernández JI, Seuc AH, Chirino N, Hernández MJ. Caracterización del pie diabético y algunos de sus factores de riesgo. Rev Cubana Angiol Cir Vasc [Internet]. 2010 [citado 22 Oct 2019];11(1). Disponible en: Disponible en: http://bvs.sld.cu/revistas/ang/vol11_01_10/ang02110.htm
Valdés ER, Espinosa Y. Factores de riesgo asociado con la aparición de enfermedad arterial periférica en personas con diabetes mellitus tipo 2. Rev Cubana Med [Internet]. 2013 [citado 22 Oct 2019];52(1):4-13. Disponible en: Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232013000100002&lng=es&nrm=iso&tlng=es
Garcia Garcia Y, Guerra L, Dominguez E, González O, Acosta A, González A. Enfermedad arterial periférica asintomática en personas con diabetes tipo 2. Rev Cubana Angiol Cir Vasc. 2020[citado 12 enero 2020];21(3). Disponible en: Disponible en: http://www.revangiologia.sld.cu/index.php/ang (En progreso)
Boyko EJ, Seelig AD, Ahroni JH. Limb‑ and person‑level risk factors for lower‑limb amputation in the prospective Seattle diabetic foot study. Diabetes Care. 2018;41(4I):891-98. DOI: 10.2337/dc17-2210
Frank U, Nikol S, Belch J, Boc V, Brodmann M, Carpentier PH. European Society for Vascular Medicine (ESVM). Guideline on peripheral arterial disease. VASA. 2019;48(102):1-79. DOI: 10.1024/0301-1526/a000834
Hirsch AT, Criqui MH, Treat-Jacobson D, Regensteiner GJ, Creager MA, Olin JW, et al. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001;286:1317-24. DOI: 10.1001/jama.286.11.1317
Lowry D, Saeed M, Narendran P, Tiwari A. A review of distribution of atherosclerosis in the lower limb arteries of patients with diabetes mellitus and peripheral vascular disease.Vasc Endov Surg. 2018;52(7):535-42. DOI: 10.1177/1538574418791622
Mohammedi K, Woodward M, Hirakawa Y, Zoungas S, Williams B, Lisheng L, et al. Microvascular and macrovascular disease and risk for major peripheral arterial disease in patients with type 2 diabetes. Diabetes Care. 2016;39(10I):1796-803. DOI: 10.2337/dc16-0588
Nativel M, Potier L, Alexandre L, Baillet-Blanco L, Ducasse E, Velho G, et al. Lower extremity arterial disease in patients with diabetes: a contemporary narrative review. Cardiovasc Diabetol. 2018; 17:138-42. DOI: 10.1186/s12933-018-0781-1
Motsumi MJ, Naidoo NG. Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford clinical category 4-6). S Afr J Surg. 2017;55:48-54.
Savigne W, Fernández JI, Fernández-Brito JE, Aldama A. Descripción aterométrica de las lesiones en extremidades inferiores en pacientes diabéticos. Rev Cubana Angiol Cir Vasc. 2001 [acceso 27/01/2020];2(1):22-6. Disponible en: Disponible en: http://bvs.sld.cu/revistas/ang/vol2_1_01/ang04101.htm
Darling JD, Bodewes TCF, Deery SE, Guzman RJ, Wyers MC, Hamdan AD, et al.. Outcomes after frst‑time lower extremity revascularization for chronic limb‑threatening ischemia between patients with and without diabetes. J Vasc Surg. 2018;67(4I):1159-69. DOI: 10.1016/j.jvs.2017.06.119
Aboyans V, Ricco JB, Bartelink MLEL, Bjorck M, Brodmann M, Cohnert T, et al. ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS). Eur H J. 2018;39(9):763-816. DOI: 10.1093/eurheartj/ehx095
Faglia E, Favales F, Quarantiello A, Calia P, Clelia P, Brambilla G, et al. Angiographic evaluation of peripheral arterial occlusive disease and its role as a prognostic determinant for major amputation in diabetic subjects with foot ulcers. Diabetes Care. 1998;21:625-30. DOI: 10.2337/diacare.21.4.625
Criqui MH, Fronek A, Klauber MR, Barrett-Connor E, Gabriel S. The sensitivity, specificity, and predictive value of traditional clinical evaluation of peripheral arterial disease: results from noninvasive testing in a defined population. Circulation. 1985;71:516-22. DOI: 10.1161/01.cir.71.3.516
Armstrong DWJ, Tobin C, Matangi MF. The accuracy of the physical examination for the detection of lower extremity peripheral arterial disease. Can J Cardiol. 2010;26(10):e346-e350. DOI: 10.1016/s0828-282x(10)70467-0
Ato D. Pitfalls in the ankle-brachial index and brachial-ankle pulse wave velocity. Vasc Health Risk Manag. 2018;14:41-62. DOI: 10.2147/VHRM.S159437
Ozdemir BA, Brownrigg JR, Jones KG, Thompson MM, Hinchliffe RJ. Systematic review of screening investigations for peripheral arterial disease in patients with diabetes mellitus. Surg Tech Int. 2013 [acceso 27/01/2020]; 23:51-58. Disponible en: Disponible en: https://pubmed.ncbi.nlm.nih.gov/23975445 /
Gerhard-Herman MD, Gornik HL, Barrett C, Barshes NR, Corriere MA, Drachman DE, et al. 2016 AHA/ACC guideline on the management of patients with lower extremity peripheral artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2017;135(12):726-79. DOI: 10.1161/CIR.0000000000000471
Spreen MI, Gremmels H, Teraa M, Sprengers RW, Martens JM, Verhaar MC, et al. High and immeasurable ankle-brachial index as predictor of poor amputation-free survival in critical limb ischemia. J Vasc Surg. 2018;67(6):1864-71. DOI: 10.1016/j.jvs.2017.10.061
Aldama A, Vega M, Ley J, Fernandez J, Lima B, Alvarez H, et al. Haemodynamic classification of macroangiophaty diabetic. J Vasc Invest. 1998;4:171-4.
Alves-Cabratosa L, Comas-Cufí M, Ponjoan A, Garcia-Gil M, Martí-Lluch R, Blanch J, et al. Levels of ankle-brachial index and the risk of diabetes mellitus complications. BMJ Open Diabetes Res Care. 2020;8(1). DOI: 10.1136/bmjdrc-2019-000977
Hendriks EJE, Westerink J, de Jong PA, de Borst GJ, Nathoe HM, Mali WPTM, et al. Association of high ankle brachial index with incident cardiovascular disease and mortality in a high-risk population. Arter Throm Vasc Biol. 2016;36(2):412-7. DOI: 10.1161/ATVBAHA.115.306657
Natsuaki C, Inoguchi T, Maeda T, Yamada T, Sasaki S, Sonoda N, et al. Association of borderline ankle-brachial index with mortality and the incidence of peripheral artery disease in diabetic patients. Atherosclerosis. 2014;234:360-5. DOI: 10.1016/j.atherosclerosis.2014.03.018
Yan BP, Zhang Y, Kong APS, Luk AOY, Ozaki R, Yeung R, et al. Borderline ankle-brachial index is associated with increased prevalence of micro- and macrovascular complications in type 2 diabetes: A cross-sectional analysis of 12,772 patients from the Joint Asia Diabetes Evaluation Program. Diab Vasc Dis Research. 2015;12(5)334-41. DOI: 10.1177/1479164115590559
Azzopardi YM, Gatt A, Chockalingam N, Formosa C. Agreement of clinical tests for the diagnosis of peripheral arterial disease. Prim care diab. 2019;13:82-6. DOI: https://doi.org/10.1016/j.pcd.2018.08.005
Álvaro-Afonso FJ, García-Morales E, Molines-Barroso RJ, García-Álvarez Y, Sanz-Corbalán I, Lázaro-Martínez L. Interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation in patients with diabetes. Diab Vasc Dis Res. 2018;1-4. DOI: https://doi.org/10.1177/1479164118767599
Tehan PE, Santos D, Chuter VH. A systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease. Vasc Med. 2016;21(4):382-89. DOI: 10.1177/1358863X16645854
Høyer C, Høgh AL, Sandermann J, Zacho HD, Petersen LJ. Risk factors and haemodynamic variables in patients with low toe-brachial index but normal ankle-brachial index. Atherosclerosis. 2019;289:21-6. DOI: 10.1016/j.atherosclerosis.2019.08.005
Brooks B, Dean R, Patel S, Wu B, Molyneaux L, Yue DK. TBI or not TBI: that is the question. Is it better to measure toe pressure than ankle pressure in diabetic patients? Diabet Med. 2001;18:528-32. DOI: 10.1046/j.1464-5491.2001.00493.x
Kumar MS, Lohiya A, Ramesh V, Behera P, Palepu S, Rizwan SA. Sensitivity and specificity of pulse oximetry and ankle-brachial index for screening asymptomatic peripheral vascular diseases in type 2 diabetes mellitus. J Assoc Physicians India. 2016 [acceso 27/01/2020];64:38-43. Disponible en: Disponible en: https://pubmed.ncbi.nlm.nih.gov/27762107 /
Vriens B, D’Abate F, Ozdemir BA, Fenner C, Maynard W, Budge J, et al. Clinical examination and non-invasive screening tests in the diagnosis of peripheral artery disease in people with diabetes-related foot ulceration. Diabet Med. 2018;35:895-902. DOI: 10.1111/dme.13634
Sigvant B, Lundin F, Wahlberg E. The risk of disease progression in peripheral arterial disease is higher than expected: A meta-analysis of mortality and disease progression in peripheral arterial disease. Eur J Vasc Endovasc Surg. 2016;51:395-403. DOI: 10.1016/j.ejvs.2015.10.022
Mohammedi K, Woodward M, Zoungas S, Li Q, Harrap S, Patel A, et al. Absence of Peripheral Pulses and Risk of Major Vascular Outcomes in Patients With Type 2 Diabetes. Diab Care. 2016;39:2270-77. DOI: 10.2337/dc16-1594
Criqui MH, Langer RD, Fronek A. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 1992;326:381-6. DOI: 10.1056/NEJM199202063260605.
The US Preventive Services Task Force (USPSTF) members.Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index US Preventive Services Task Force Recommendation Statement. JAMA. 2018;320(2):177-83. DOI: 10.1001/jama.2018.8357
American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care. 2003;26:3333-41. DOI: 10.2337/diacare.26.12.3333
American Diabetes Association. 11. Microvascular complications and foot care: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020;43(Suppl.1):S135-S51. DOI: https://doi.org/10.2337/dc20-S011