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2021, Number 3

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Rev Mex Patol Clin Med Lab 2021; 68 (3)

T cells and NK cell reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT)

Parra-Ortega I, Gaytán-Morales JF, Castorena-Villa I, Mier-Cabrera M, López-Martínez B, Ortiz-Navarrete V, Olvera-Gómez I

Language: Spanish
References: 69
Page: 123-133
PDF size: 299.53 Kb.


ABSTRACT

Hematopoietic stem cell transplantation (HSCT) is the established treatment for children with leukemia that do not respond to chemotherapy, as well as benign alterations. Among the biological processes that generate the success of HSCT is the generation of an efficient immune system, establishing an environment of homeostasis between the different cellular and soluble (cytokines, chemokines) components to control several interactions between the cells that participate in the process. The complete reconstitution of adaptive immunity is often affected by several factors. Some of them are inherent to the transplant, which takes even years to obtain an adequate number of lymphoid cells with optimal functionality. Adaptive immune reconstitution takes a long time, which increases the risk of failing to respond against opportunistic infectious agents. Moreover monitoring the factors that directly influence the success of the graft, T lymphocytes subpopulatios, and NK cells should be quantified. This correlates with the clinical status and the progress in cellular reconstitution allowing the identification of the ideal moment to carry out interventions that accompany the long recovery period. This is in order to contribute to achieving a state of immunocompetence of the individual.


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