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2022, Number 1

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Dermatología Cosmética, Médica y Quirúrgica 2022; 20 (1)

Neutrophilic dermatoses associated to monogenic autoinflammatory syndromes

Giraldo LN, Velásquez MM

Language: Spanish
References: 62
Page: 67-77
PDF size: 585.78 Kb.


ABSTRACT

Neutrophilic dermatoses are a heterogeneous group of inflammatory skin diseases characterized on histology by intense neutrophilic infiltrate in the epidermis, dermis or hypodermis without evidence of infection. They are caused by the increase in proinflammatory cytokines and chemokines that lead to the recruitment of immune cells in the tissues, inflammation and development of lesions in the skin, other organs and symptoms of systemic inflammation.
There are monogenic autoinflammatory syndromes with neutrophilic dermatosis-like manifestations generated by mutants in protein genes that are part of the innate immune system such as components of the inflammasome, keratinocyte proteins such as card-14, and deregulation of signaling pathways such as il-36.
This article aims to describe the molecular pathways that give rise to monogenic autoinflammatory syndromes that manifest as neutrophilic dermatosis and often to describe their clinical characteristics.


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