2022, Number 04
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Ginecol Obstet Mex 2022; 90 (04)
Cytocolposcopic concordance with histopathologic testing in the identification of cervical intraepithelial neoplasia
Medina-de la Cruz O, Reyes-Laris P, Gaytán-Hernández D, Gallegos-García M, Gallegos-García V
Language: Spanish
References: 27
Page: 323-330
PDF size: 312.52 Kb.
ABSTRACT
Objective: To evaluate the diagnostic concordance between cytology and colposcopy
with respect to the histopathological diagnosis of cervical cancer in women from the
state of San Luis Potosí who attended a second-level care hospital.
Materials and Methods: Correlational study performed in a second-level care
hospital in the municipality of San Luis Potosí, between 2015 and 2017. Inclusion
criteria: to gather three reports of Papanicolaou, colposcopy and histopathology tests
based on Richart's classification, to be users of the hospital's colposcopy clinic and to
have signed the informed consent. To evaluate the diagnostic concordance, taking the
histopathological result as a reference, the Kappa test was performed.
Results: We studied 379 patients with a mean age of 34.61 years. The sensitivity,
specificity, positive and negative predictive value of the Papanicolaou test were: 95.60,
6.60, 96.13 and 5.82%, respectively. The sensitivity, specificity, positive and negative
predictive value of colposcopy were: 95.98, 33.33, 98.90 and 11.76%, respectively.
When doing the Kappa test the outcome for Papanicolaou was: 0.021 (p = 0.677) and
for colposcopy 0.154 (p = 0.001).
Conclusions: The sensitivity of the Papanicolaou diagnostic test and colposcopy
was high as was the positive predictive value. It is important to analyze the variables
that could be causing the diagnostic discordance between Papanicolaou-colposcopyhistopathology.
REFERENCES
Secretaría de Salud. Modificación a la Norma Oficial Mexicana NOM-014-SSA2-1994, Para la prevención, detección, diagnóstico, tratamiento, control y vigilancia epidemiológica del cáncer cérvico uterino. Diario Oficial de la Federación México: 2007. http://www.dof.gob.mx/ normasOficiales/2383/SALUD/SALUD.htm
Velázquez-Hernández N, Sánchez-Anguiano LF, Lares-Bayona EF, Cisneros-Pérez V, et al. Comparación de la utilidad diagnóstica entre la inspección visual con ácido acético y la citología cervical. Ginecol Obstet Mex 2010; 78 (05): 261-67.
Alliance for Cervical Cancer P. Planning and implementing cervical cancer prevention and control programs: a manual for managers. Alliance for Cervical Cancer Prevention: 2004. https://iris.paho.org/handle/10665.2/34885
Jiménez-Pérez M, Thomas DB. Has the use of pap smears reduced the risk of invasive cervical cancer in Guadalajara, Mexico?. Int J Cancer 1999; 82 (6): 804-9. https://doi. org/10.1002/(SICI)1097-0215(19990909)82:6<804::AIDIJC6> 3.0.CO;2-N
Díaz-Amézquita EL, de Larios NM, Valdez IYD. Correlación citológica-colposcópica e histológica de lesiones de bajo y alto grado en cérvix. Rev Hosp Gen Dr. Manuel Gea González 2006; 7 (2): 54-58.
Shader RI. The PAP test and the pap smear. Clin Ther. 2015; 37 (1): 1-3. https://www.clinicaltherapeutics.com/article/ S0149-2918(14)00811-X/fulltext
Tuon FFB, Bittencourt MS, Panichi M, Pinto AP. Avaliação da sensibilidade e especificidade dos exames citopatológico e colposcópico em relação ao exame histológico na identificação de lesões intra-epiteliais cervicais. Rev Aassoc Med Bras 2002; 48 (2): 140-44. http://dx.doi.org/10.1590/ S0104-42302002000200033
Richart RM. Cervical intraepithelial neoplasia. Pathol Annu 1973; 8: 301-28.
Tranbaloc P. Histoire naturelle des lésions précurseurs du cancer du col utérin. Gynecol Obstet Fertil 2008; 36 (6): 650-55. https://doi.org/10.1016/j.gyobfe.2008.03.016
Ponce ECL, Castañeda CI. Sobreutilización del servicio de colposcopia en México. Ginecol Obstet Mex 2005; 73 (12): 637-47.
Khan MJ, Werner CL, Darragh TM, Guido RS, et al. ASCCP colposcopy standards: role of colposcopy, benefits, potential harms, and terminology for colposcopic practice. J Low Genit Tract Dis 2017; 21 (4): 223-29. doi: 10.1097/ LGT.0000000000000338
Villegas-Hinojosa E, Gallegos-García V, Campuzano-Barajas AE, Medina de la Cruz O, Alcántara-Quintana LE. El estudio histopatológico del tejido cervical e importancia de su revisión a más niveles en el bloque de parafina para su precisión diagnóstica. Tequio 2018; 4 (1): 15-25. https://uabjo. slm.cloud/?v=article.main&id=VBHRPHwBuGQNBlBvIwis
Sánchez-Nava MF, Olivares-Montano AK, Contreras-Carreto NA, Díaz-Suárez MM. Certeza diagnóstica de la colposcopia, citología e histología de las lesiones intraepiteliales del cérvix. Med Sur 2018; 20 (2): 95-99. https://urgencias.medicasur. com.mx/pdf-revista/RMS132-AO02-PROTEGIDO.pdf
Nanda K, McCrory DC, Myers ER, Bastian LA, et al. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Ann Intern Med 2000; 132 (10): 810-19. doi: 10.7326 / 0003- 4819-132-10-200005160-00009
Mustafa RA, Santesso N, Khatib R, Mustafa AA, et al. Systematic reviews and metaanalyses of the accuracy of HPV tests, visual inspection with acetic acid, cytology, and colposcopy. Int J Gynecol Obstet 2016; 132 (3): 259-65. https://doi.org/10.1016/j.ijgo.2015.07.024
Singhal A, Raina RK, Verma S, Verma A. Predictive accuracy of cervical cytology and colposcopy in diagnosing premalignant and malignant cervical lesions: A hospital-based study from the sub-Himalayan region of Indian subcontinent. Chrismed J Health Res 2019; 6 (1): 39. doi: 10.4103/cjhr. cjhr_51_18
Barut MU, Kale A, Kuyumcuoğlu U, Bozkurt M, et al. Analysis of sensitivity, specificity, and positive and negative predictive values of smear and colposcopy in diagnosis of premalignant and malignant cervical lesions. Med Sci Monit 2015; 21: 3860. doi: 10.12659/MSM.895227
Bamanikar SA, Baravkar D, Chandanwale S, Dharwadkar A, et al. Study of cervical cytology and its correlation with clinical and histopathological findings. Clinic Cancer Invest J 2016; 5 (5): 403. doi: 10.4103/2278-0513.197869
Rajendiran S, Gopalan U, Karnaboopathy R. Evaluation of histopathology of cervix in women with unhealthy cervix. Int J Reprod Contracept Obstet Gynecol 2017; 6 (3): 842-45. doi:10.18203/2320-1770.ijrcog20170465
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR. Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias. Rev Bras Ginecol Obstet 2018; 40 (7): 410-16. https://doi.org/10.1055/s-0038-1666995
Del Villar-García K, Ciriaco SV, Matus RG, Ramírez FT, et al. Correlación diagnóstica entre la colposcopia y la citología en lesiones del cuello uterino. Evid Med Invest Salud 2013; 6 (3): 84-88.
Cordiner JW, Sharp F, Briggs JD. Cervical intraepithelial neoplasia in immunosuppressed women after renal transplantation. Scott Med J 1980; 25 (4): 275-77. https://doi. org/10.1177/003693308002500405
Gaudette LA, Gao RN, Freitag S, Wideman M. Cancer incidence by ethnic group in the Northwest Territories (NWT) 1969-1988. Health Rep 1993; 5 (1): 23-32.
Dalla-Palma P, Rossi PG, Collina G, Buccoliero AM, et al. The risk of false-positive histology according to the reason for colposcopy referral in cervical cancer screening: a blind revision of all histologic lesions found in the NTCC trial. Am J Clin Pathol 2008; 129 (1): 75-80. doi: 10.1309/ewygwfrrm8798u5p
Gallegos-García V, Gallegos-García M, Mota GP, Escoto- Chávez SE. Cáncer cervicouterino. Causas de citología no útil. Rev Latin Patol Clina Med Lab 2012; 59 (1): 23-27.
Bomfim-Hippolito S. Cytology as a cervical screening test: How effective is it. Geneva Foundation for Medical Education and Research. 8th Postgraduate course for training in reproductive medicine and reproductive biology 2003. https://www.gfmer.ch/Endo/PGC_network/ Cytology_as_a_cervical_screening_test_Hyppolito.htm
Nayak PK, Mitra S, Agrawal S, Hussain N, et al. Role of various screening techniques in detecting preinvasive lesions of the cervix among symptomatic women and women having unhealthy cervix. J Cancer Res Ther 2021; 17 (1): 180-85. doi: 10.4103/jcrt.JCRT_30_19