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TIP Revista Especializada en Ciencias Químico-Biológicas

2021, Number 1

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TIP Rev Esp Cienc Quim Biol 2021; 24 (1)

Galectins in blood coagulation

Fernández-Rojas B, Arreola-Díaz R, Hernández-Cruz PA, Gallegos-Velasco IB, Solórzano-Mata CJ, Argueta-Figueroa L, Hernández-Juárez J

Language: Spanish
References: 36
Page:
PDF size: 258.90 Kb.


ABSTRACT

Haemostasis is a phenomenon of high biological value that involves the participation of cellular and plasma elements through which clots are formed at site of vascular injury to prevent people die by a hemorrhage. On the contrary, in thrombosis, a pathological clot or thrombus is formed that obstructs blood flow and can lead patients to death.
On the other hand, galectins are a group of proteins belonging to lectins families, which do not possess enzymatic activity or have an immune origin, but recognize specific carbohydrates in cells. Its contribution has been determined in physiological and pathological processes, such as cancer and atherosclerosis. In this review the role of galectin-1 (Gal-1), galectin-3 (Gal-3) and galectin-8 (Gal-8) in the hemostatic process will be described, as well as the most recent findings that suggest their probable involvement in thrombotic diseases.


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