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TIP Revista Especializada en Ciencias Químico-Biológicas

2021, Número 1

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TIP Rev Esp Cienc Quim Biol 2021; 24 (1)


Las galectinas en la coagulación sanguínea

Fernández-Rojas B, Arreola-Díaz R, Hernández-Cruz PA, Gallegos-Velasco IB, Solórzano-Mata CJ, Argueta-Figueroa L, Hernández-Juárez J

Idioma: Español
Referencias bibliográficas: 36
Paginas:
Archivo PDF: 258.90 Kb.


RESUMEN

La hemostasia es un fenómeno de alto valor biológico que comprende la participación de elementos celulares y plasmáticos a través de los que se forman coágulos en los sitios de lesión vascular para evitar que las personas mueran a causa de una hemorragia.
Por el contrario, en la trombosis, se forma un coágulo patológico o trombo que obstruye el flujo sanguíneo afectando a tejidos y órganos, lo que puede llevar a la muerte. Por su parte, las galectinas son un grupo de proteínas de la familia de las lectinas, que, no poseen actividad enzimática ni tienen un origen inmune, pero reconocen a carbohidratos específicos en las células. Se ha demostrado su contribución en procesos fisiológicos y patológicos, como el cáncer y la aterosclerosis. En esta revisión se describirá, el papel de la galectina-1 (Gal-1), la galectina-3 (Gal-3) y la galectina-8 (Gal-8) en el proceso hemostático, así como los hallazgos más recientes que sugieren su probable participación en las trombosis.


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