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TIP Revista Especializada en Ciencias Químico-Biológicas

2021, Number 1

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TIP Rev Esp Cienc Quim Biol 2021; 24 (1)

Use of 13C-glucose breath test to assess treatment adherence in nutritional intervention trials

García-Rojas V, Maldonado-Hernández J, Mora-Escobedo R, Izquierdo-Montalvo G, Verma MP, Aragón-Aguilar A, Ángel-Serrato D, Encarnación-Fernández JS, San Martín-Martínez E

Language: English
References: 12
Page:
PDF size: 191.01 Kb.


ABSTRACT

Objective: To validate the use of the 13C-glucose breath test to assess nutritional treatment adherence. Methods: A pilot study was conducted on eleven adults. A snack made of soybean/corn-starch was enriched with U-13C-glucose. The participants were divided in three groups that consumed the snack in different periods for two weeks (A=14 days, B=10 days and C=6 days). Breath samples were collected daily to analyse the δ13C values with isotope-ratio mass spectrometry. Results: AUC (area under the curve) median of δ13C values of group A was higher than group C (p = 0.029); differences were found when combining groups, A and B medians, comparing them with group C (p = 0.038). A negative association was found between AUC δ13C values and treatment intensity (Spearman rho = -0.708; p = 0.015). A cut-off ≤3.78 identifies subjects with less than 70% accomplishment of the treatment with 100% specificity and 86% sensitivity. Conclusions: The 13C-glucose breath test suggests a good diagnostic performance to assess treatment adherence.


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