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Boletín Clínico de la Asociación Médica del Hospital Infantil del Estado de Sonora

2021, Number 2

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Bol Clin Hosp Infant Edo Son 2021; 38 (2)

Isommunization with anti-E in positive O-Rh binomial. Presentation of an unusual case

Quero-Hernández A, Quero-Estrada A, Reyes-Gómez U, Reyes-Hernández KL, Hernández-Noyola AL, Santiago-Valdivieso U, Avendaño-López JR

Language: Spanish
References: 21
Page: 148-154
PDF size: 149.39 Kb.


ABSTRACT

Hemolytic disease due to maternal-fetal incompatibility to the Rh phenotype is the result of maternal sensitivity to a foreign antigen transfused by the fetus. The present work describes the incompatibility of the maternal-fetal RH phenotype. The clinical case of a male new born presented, 28-year-old mother´s son, both ORH +. The current condition began with 24 hours of extra-uterine life with jaundice, with Hb 16.5 gr/dl and reticulocytes 11%. Positive direct Coombs. Indirect Coombs to positive mother. Anti-E is identified in the mother’s serum and the same Anti-E on the surface of the neonates erythrocyte. The Rh phenotype of the neonate (CECe) and the mother (CeCe) were incompatible. He was treated with intravenous gamma globulin and red blood transfusion compatible with the maternal Rh phenotype. The Rh system is the most complex of the blood groups, the most important being C, c, D, E and e antigens. Our case described here, presented the clinical characteristics of hemolytic disease in the first 24 hours after birth, the diagnosis could be established by performing the Rh immunophenotyping, on the newborn (CECe) and its mother (CeCe) and the immunogenic difference that gave rise to the maternal-fetal incompatibility. It is important of identify the Rh immunophenotype in our population as primary prevention in pregnant women and in those women in the reproductive stage who will be transfused.


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