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2002, Number 3

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Rev Endocrinol Nutr 2002; 10 (3)

Visceral fat and its importance in obesity

Godínez GSA, Marmolejo OGE, Márquez RE, Siordia VJJ, Baeza CR

Language: Spanish
References: 41
Page: 121-127
PDF size: 78.05 Kb.


ABSTRACT

Human obesity is characterized by a wide variation in the distribution of excess body fat, and the distribution of fat affects the risks associated with obesity as well as the kinds of comorbidities that result. Central obesity is thus more strongly associated with comorbidities in various systems than is peripheral obesity. This is particularly evident when intra-abdominal, visceral depots are enlarged. Visceral obesity is, also associated with endocrine abnormalities, in cortisol, growth hormone and sex steroids dynamics, with a profound effect on peripheral tissues. Indeed, visceral obese individuals with the metabolic syndrome may have all hormonal abnormalities of the elderly, suggesting that this condition may be a sign of premature ageing.


REFERENCES

  1. Vague J. La differentiation sexuelle, facteur determinant des formes de l’obesity. Presse Medicale 1947; 30: 339-340.

  2. Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. 1956. Obes Res 1996; 4: 204-212.

  3. Després JP, Allard C, Tremblay A, Talbot J, Bouchard C. Evidence for a regional component of body fatness in the association with serum lipids in men and women. Metabolism 1985; 34: 967-73.

  4. Björntorp P. Regional Obesity and NIDDM. Adv Exp Med Biol 1993; 334: 279-85.

  5. Kissebah AH, Vydelingum N, Murray R et al. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982; 54: 254-60.

  6. Goran MI, Bergman RN, Gower BA. Influence of total vs visceral fat on insulin action and secretion in African-American and white children. Obes Res 2001; 9: 423-431.

  7. Ross R, Shaw KD, Rissanen J, Martel Y, de Guise J, Avruch L. Adipose tissue distribution measured by magnetic resonance imagining in obese women. Am J Clin Nutr 1993; 57: 470-475.

  8. Fujioka S, Matsuzawa Y, Tokunaga K, Kawamoto T, Kobatake T, Keno Y, Kotani K. Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral fat obesity. Int J Obes 1990; 15: 853-859.

  9. Riches FM, Watts GF, Hua J, Stewart GR, Naoumova RP, Barrett PHR. Reduction in visceral adipose tissue is associated with improvement in apolipoprotein B-100 metabolism in obese men. J Clin Endocrinol Metab 1999; 84: 2854-2861.

  10. Barzilai N, She L, Liu B-Q, Vuguin P, Cohen P, Wang J, Rossetti L. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 1999; 48: 94-98.

  11. Roncari DAK. Pre-adipose cell replication and differentiation. TIBS 1984; 9: 486-489.

  12. Lau DCW, Shillabeer Z-H Li, Wong FE, Varzaneh and SC Tough. Paracrine interactions in adipose tissue development and growth. Int J Obes 1996; 20: S17-S25.

  13. Comuzzie A, Allison D. The search for human obesity genes. Science 1998; 280: 1374-1377.

  14. Bouchard C, Després JP, Rice T, Lemieux S, Perusse L, Rao DC. Major gene for abdominal visceral fat area in the Quebec family study. Int J Obes 1996; 20: 420-427.

  15. Bouchard C, Després JP, Mauriége P. Genetic and non-genetic determinants of regional fat distribution. Endocr Rev 1993; 34: 72-93.

  16. Elbers JM, Asscheman H, Seidell JC, Megens JA, Gooren LJ. Long-term testosterone administration increases visceral fat in female to male transsexuals. J Clin Endocrinol Metab 1997; 82: 2044-2047.

  17. Cao H, Hegele RA. Nuclear Lamin A A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum Mol Gen 2000; 9: 109-112.

  18. Faloia E, Camilloni MA, Giacchetti G, Mantero F. Adipose tissue as an endocrine organ? A review of some recent data. Eating Weight Disord 2000; 5: 116-123.

  19. Lefebvre AM, Laville M, Vega N, Riou JP, Van Gaal L, Auwerx J, Vidal H. Depot-Specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998; 47: 98-103.

  20. Fried SK, Russell CD, Grauso NL, Brolin RE. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest 1993; 92: 2191-2198.

  21. Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect “Cushing disease of the omentum”? Lancet 1997; 349: 1210-1213.

  22. Dieudonne M, Pecquery R, Boumediene A, Leneveu M, Giudicelli Y. Androgen receptors in human preadipocytes and adipocytes: regional especificities and regulation by sex steroids. Am J Physiol 1998; 274: C1645-C1652.

  23. Montague CT, O’Rahilly SO. Causes and consequences of visceral adiposity: The perils and portliness. Diabetes 2000; 49 (6).

  24. Montague CT, Prins JB, Sanders L, Digby JE, O’Rahilly S. Depot and sex-specific differences in human leptin mRNA expression. Diabetes 1997; 46: 342-347.

  25. Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y. Enhanced expression of PAI-1. In visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2: 800-803.

  26. Huang TT, Johnson MS, Figueroa-Colon R, Dwyer JH, Goran MI. Growth of visceral fat, subcutaneous abdominal fat and total body fat in children. Obes Res 2001; 9: 283-289.

  27. Goran MI, Nagy TR, Treuth MT et al. Visceral fat in Caucasian and African-American pre-pubertal children. Am J Clin Nutr 1997; 65: 1703-1709.

  28. Gower BA, Nagy TR, Goran MI. Visceral fat, insulin sensivity and lipids in pre-pubertal children. Diabetes 1999; 48: 1515-1521.

  29. Goran MI, Bergman RN, Gower BA. Influence of total vs. Visceral fat on insulin action and secretion in African-American and white children. Obes Res 2001; 9: 423-431.

  30. Rosmond R, Dallman MF, Björntorp P. Stress-related cortisol in men: Relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 1998; 83: 1853-1859.

  31. Björntorp P. The regulation of adipose tissue distribution in humans. Int J Obes 1996; 20: 291-302.

  32. Björntorp P. Neuroendocrine perturbations as a cause of insulin resistance. Diabetes/Metabolism Res Rev 1999; 15: 1-15.

  33. Björntorp P. Abdominal fat distribution and disease: An overview of epidemiological data. Ann Med 1992; 24: 416-422.

  34. Comings DE. Polygenic inheritance and micro/minisatellites. Mol Psychiatry 1998; 3: 21-31.

  35. Björntorp P, Holm G, Rosmond R, Folkow B. Hypertension and the metabolic syndrome. Closely related central origin? Blood Press 2000; 9: 71-82.

  36. Pasquali R, Casimirri F. The impact of obesity on hyperandrogenism and polycystic ovary in premenopausal women. Clin Endocrinol (Oxf) 1993; 39: 1-16.

  37. Nestler JE, Baralascini CO, Matt DW, Steingold KA, Plymate SR, Clore JN, Blackard WG. Suppression of serum insulin diazoxide reduces serum testosterone levels in obese women with Polycystic ovary syndrome. J Clin Endocrinol Metab 1989; 68: 1027-1032.

  38. Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects of d-chiro inositol in the polycystic ovary syndrome. N Engl J Med 1999; 340: 1314-1320.

  39. Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles JM. Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 1989; 83: 1168-1173.

  40. Simoneau J-A, Colberg SR, Thaete FL, Kelley DE. Skeletal muscle glycolitic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 1995; 9: 273-278.

  41. Kelley DE, Slasky BS, Janosky J. Skeletal muscle density: effect of obesity and non-insulin dependent diabetes mellitus A. J Clin Nutr 1991; 54: 509-515.




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