Dueñas RAA, Alcívar CUE, Sacon VEF, Cedeño PC, Delgado DH, Marrero CO

Language: Spanish
References: 20
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ABSTRACT

Introduction: Chuquiraga jussieui J.F. Gmel is a wild plant species that grows in the Ecuadorian Andes. It is broadly used by ancestral cultures and the common population as folk medicine, particularly as antidiabetic, anti-inflammatory and febrifuge.
Objectives: Determine the hypoglycemic effect of aqueous extract from Chuquiraga jussieui in rats with induced diabetes.
Methods: Determination of the hypoglycemic effect was conducted in rats from the Wistar isogenic line with induced hyperglycemia. Six groups were formed: normal control without treatment, hyperglycemic control with streptozotocin, hyperglycemic control treated with the hypoglycemic drug glibenclamide, and aqueous extract from Chuquiraga jussieui at three concentrations (100, 200 and 400 mg/kg body weight). Statistical assessment of results included normal distribution by the Shapiro–Wilk test, variance homogeneity by Levene's test, analysis of variance between the groups, and multiple comparisons by Tukey's tests.
Results: The streptozotocin group with induced hyperglycemia and no treatment showed a significant mean glycemia increase throughout the study. The glibenclamide group showed a significant decrease of over 8 mmol/l, and so did the three extract groups (concentrations of 100, 200 and 400 mg/kg) treated with various volumes of extracts from the study plant, the contrast being greater in the latter group.
Conclusions: It was determined that aqueous extract from Chuquiraga jussieui J.F. Gmel displays hypoglycemic activity as of 400 mg/kg versus a drug in a model for type 2 diabetes mellitus.

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