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ISSN 2225-4676 (Electronic)

2020, Number 2

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Rev Cubana Neurol Neurocir 2020; 10 (2)

Autoimmune encephalitis due to antibodies against n-methyl-d-aspartate receptor with neuropsychiatric presentation

Altamirano CAM, González LM

Language: Spanish
References: 20
Page: 1-13
PDF size: 262.43 Kb.


ABSTRACT

Objective: To describe the clinical manifestations of the first case of autoimmune encephalopathy due to antibodies against n-methyl-d-aspartate receptor, confirmed in Pastaza, Ecuador.
Clinical case: A 34-year-old male patient is reported because of insidious behaviour disorders associated with progressive impairment of cognitive functions. He underwent psychiatric evaluation and tests to detect autoimmune diseases, which resulted negative. Due to the presentation of these neurological and psychiatric manifestations in a young patient, a surface electroencephalogram and detection of antibodies against the n-methyl-d-aspartate receptor were indicated for the final diagnosis and to prescribe therapy. The patient was found to have autoimmune encephalopathy. After treatment with steroids, the patient evolved favorably.
Conclusion: The clinical manifestations of this case were mental dysfunctions such as insomnia of conciliation and maintenance of sleep, abnormal behaviors, irritability, impulsivity, aggressiveness, hypersexuality, compulsion, zealoty, rambling language and memory disorder in the short and medium term.


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