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2021, Number 3

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Rev Educ Bioquimica 2021; 40 (3)

La función de la O-β-N Acetilglucosamina (O-GLCNAC) en los procesos de enfermedad

Fuentes-García G, Patlán-Castañeda C, Lefebvre T, Robles-Flores M

Language: Spanish
References: 159
Page: 128-144
PDF size: 476.87 Kb.


ABSTRACT

O-GlcNAcylation is a non-canonical glycosylation that consists of a linkage of OGlcNAc motif to Serine and Threonine residues of different proteins. Since O-GlcNAc depends on the flux of glucose, amino acids, fatty acids, and nucleotides, it has been postulated as a nutrient status sensor within the cell. However, literature describing its role in the regulation of several cellular processes has greatly increased since the discovery of O-GlcNAc. Now, O-GlcNAc is not only considered as a nutritional sensor, but as a posttranslational modification (PTM) which interacts with other PTMs, such as phosphorylation, methylation, ubiquitinylation to maintain cellular homeostasis. Likewise, it has been widely described that a disturbance in the levels of O-GlcNAc is associated with several pathologies. Thus, the present review is aimed to summarize some of the main roles of O-GlcNAcylation during different pathologies and cellular processes.


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