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2000, Number 1

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Rev Mex Patol Clin Med Lab 2000; 47 (1)

Antibiotics induce endotoxin release.

Laria LRE

Language: Spanish
References: 32
Page: 38-44
PDF size: 84.95 Kb.


ABSTRACT

Antibiotic chemotherapy to treat infections with gramnegative microbes, is an important strategy. However, basic investigation over the past decade have revealed that such treatments may result in the release of endotoxin from bacterial cell wall and that antibiotic differs in their propensity to induce the releasing of endotoxin. This releasing of endotoxin can exacerbate the inflammatory answer of the host and produce deleterial levels of IL-6 and TNFα, and can contribute to the worse of the patient outcome. The endotoxin-released property of antibiotics is related to the interaction with penicillin binding proteins present in bacterial surface and morphological changes that take lace in the bacteria. Both in vitro studies and in vivo animal experiments have provided evidence in support of this concept, however the clinical importance of this phenomenon is unclear.


REFERENCES

  1. Talan DA. Recent development in our understanding of sepsis, evaluation of anti-endotoxin antibodies and biological response modifiers. Ann Emerg Med 1993; 22(12): 1871-1890.

  2. Cometta A. Polyclonal intravenous immune globulin for prevention and treatment of infections in critically ill patients. Clin Exp Immunol 1994; 97: 60-70.

  3. Horn KD. Evolving strategies in the treatment of sepsis and systemic inflammatory response syndrome (SIRS). QJM. Monthly Journal of the Association of Physicians 1998; 91(4): 265-277.

  4. Castro BL. Trauma y sepsis. Revista Cubana Medicina Militar 1997; 26(2): 129-140.

  5. Kirikae T, Nakano M, Morrison DC. Antibiotic-induced endotoxin release from bacteria and its clinical significance. Microbial Immunol 1997. 41(4): 285-294.

  6. Morrison DC. Endotoxin and the septic patient-Differential contribution of antibiotic chemotherapy. Infections in Oncology 1997: 2-7.

  7. Wyckoff TJO, Raetz CRH, Jackman JE. Antibacterial and anti-inflammatory agents that target endotoxin. Trends in Microbiology 1998; 6(4): 154-159.

  8. Morrison DC. Antibiotic-Mediated release of endotoxin and the pathogenesis of gram-negative sepsis. Progress in Clinical and Biological Res 1996; 397: 199-207.

  9. Jackson JJ, Kropp H. Differences in mode of action of beta-lactam antibiotics influence morphology, LPS release and in vivo antibiotic efficacy. J Endotoxin Res 1996; 3(3): 201-218.

  10. Lechner AJ. A recombinant tumor necrosis factor-alfa p80 receptor. Fc fusion protein decreases circulating bioactive tumor necrosis factor-alfa but not lung injury or mortality during immunosuppression-related gramnegative bacteremia. J Crit Care 1997; 12(1): 28-38.

  11. Mercer-Jones MA. Continuous antibiotic treatment for experimental abdominal. Sepsis: Effects on organ inflammatory cytokine expression and neutrophil sequestration. British Journal of Surgery 1998; 85(3): 385-389.

  12. Morrison DC. Antibiotic-mediated endotoxin release. Contribution to pathogenesis in gram-negative sepsis. J Endotoxin Res 1996; 3(3): 110.

  13. Mock CN. The clinical significance of endotoxin released by antibiotic: what is the evidence? J of Endotoxin Res 1996; 3(3): 253-259.

  14. Xuan D. In vitro reduction of endotoxin concentrations with de 5s fragment of immunoglobulin G. Antimicrob Agents Chemother 1997; 41(7): 1512-1516.

  15. Holzheimer RG, Hirte JF, Reith B, Engelhardt W, Horak KH, Leppert R, Aasen A, Capel P, Urbaschek R, Karch H, Thiede A. Different endotoxin release and IL-6 plasma levels after antibiotic administration in sugical intensive care patients. J Endotoxin Res 1996; 3(3): 261-267.

  16. Howard BJ. Clinical and Pathogenic microbiology. 2ed. Washington DC.: Mosby Tear Book Inc, 1994: 145-148.

  17. Morrison DC. Endotoxin/Antibiotics and gram-negative sepsis. J Endotoxin Res 1996; 3(3): 171.

  18. Neu HC. Aztreonam. El primer monobactámico. Clínicas Médicas de Norteamérica 1988; 3: 605-617.

  19. Prins JM. No increase in endotoxin release during antibiotic killing of meningococci. J Antimicrob Chemother 1997; 39(1): 13-18.

  20. Trautmann M. Antibiotic-induced release of endotoxin: In-vitro, comparison of meropenem and other antibiotics. J Antimicrob Chemother 1998; 41(2): 163-169.

  21. Trautmann M, Einernann M, Zick R, Moriche A, Seidelmann M, Berger D. Antibacterial activity of meropenem against Pseudomonas aeruginosa including antibiotic induced morphological changes and endotoxing-liberating effects. Eur J Microbiol Infect Dis 1998; 17: 754-760.

  22. Morrison DC, Bucklin SE. Evidence for antibiotic mediated endotoxin release as a contributing factor to lethality in experimental gram-negative sepsis. Scand J Infect Dis 1996; Suppl 101: 3-8.

  23. Morrison DC, Bucklin SE, Leeson MC, Norimatsu M. Contribution of soluble endotoxin released from gram-negative bacteria by antibiotics to the pathogenesis of experimental sepsis in mice. Antibiotic mediated endotoxin release contibution to pathogenesis in gram-negative sepsis, J Endotoxin Res 1996 3(3): 237-243.

  24. Nakano M, Kirikae T. Biological characterization of Pseudomonas aeruginosa endotoxin released by antibiotic treatment in vitro. J Endotoxin Res 1996; 3(3): 195-200.

  25. Healy DP, Verst-Brasch CL, Clendening CE, Neely AN, Holder IA. Influence of drug class and dose size on antibiotic-induced endotoxin/interleukin-6 release and impact on efficacy of anti-endotoxin antibody. J Endotoxin Res 1996; 3(3): 219-227.

  26. Healy DP, Verst-Brasch CL, Clendening CE, Neely AN, Holder IA. Kinetics of endotoxin and interleukin-6 following multiple doses of antibiotics for experimental gram-negative bacterial sepsis. J Endotoxin Res 1996; 3(2): 93-101.

  27. Arditi M, Zhan J. Differential antibiotic-induced endotoxin release and interleukin-6 production by human umbilical vein endothelial cells (HUVECs): amplification of the response by coincubation of HUVECs and blood cells. J Infect Dis 1997; 175(5): 1255-1258.

  28. Norimatsu M, Morrison DC. Correlation of antibiotic-induced endotoxin release and cytokine production in Escherichia coli-Inoculated mouse whole blood en vivo. J Infect Dis 1998; 177(5): 1302-1307.

  29. Dofferhoff ASM, Esselink MT, De-Vries-Hospers HG, Zanten AF, Bom VJJ, Weits J, Vellenga E. The release of endotoxin from antibiotic-treated Escherichia coli and the production of tumor necrosis factor by human monocytes. J Antimicrob Chemother 1993; 31(3): 373-384.

  30. Holzheimer RG. The significance of endotoxin release in experimental and clinical sepsis in surgical patients. Evidence for antibiotic-induced endotoxin release? Infection 1998; 26(2): 77-84.

  31. Prins JM, Van-Agtmael MA, Kuijper EJ, Van-Poventer SJH, Speelman P, Antibiotic induced endotoxin release in patients with gramnegative urosepsis: A double blind study comparing imipenem and ceftazidime. J Infect Dis 1995; 172(3): 886-891.

  32. Lipman B, Neu HC. Imipenem: un nuevo antibiótico carbapenémico. Clínicas Médicas de Norteamérica 1988; 3: 591-603.




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