medigraphic.com

2020, Number 4

<< Back Next >>

Enf Infec Microbiol 2020; 40 (4)

Hematological compromise in patients with human immunodeficiency virus infection in a university hospital in the city of Medellin, Colombia

Martínez SLM, Quintero MDA, Ruiz MC, Carvajal AM, López LL, Álvarez HLF, Restrepo LMA, Hernández SJM

Language: Spanish
References: 16
Page: 130-135
PDF size: 213.17 Kb.


ABSTRACT

Hematological alterations are frequent in patients with human immunodeficiency virus (HIV), among them pancytopenia, peripheral cell destruction, among others, being anemia the most frequent finding.
Objective. To identify the most frequent hematological alterations in patients with HIV treated at a university hospital in Medellin, during 2017-2018 period.
Method. Descriptive cross-sectional study. HIV patients older than 18 years with a laboratory confirmed diagnosis were included. Those patients with absence of hematological variables in medical records were excluded. A nonprobabilistic sampling of consecutive cases was carried out. Statistical analysis was carried out in the SPSS v.25 program, quantitative variables were calculated as mean, median with interquartile range and the qualitative absolute and relative frequencies.
Results. 30 medical records were reviewed, three were excluded. The most frequent alterations were anemia, eosinopenia and hypochromia with 51.9, 48.1 and 18.5%, respectively. Anemia was reported more frequently in patients with advanced disease, as well as in patients under management with atazanavir.
Conclusion. Anemia is a very frequent comorbidity in patients with HIV.


REFERENCES

  1. Bekker, L.G., Alleyne, G., Cepeda, J., Daskalakis, D., Dowdy, D., Dybul, M. et al., “Advancing global health and strengthening the hiv response in the era of the sustainable Development Goals: The International aids Society- Lancet Commission”, The Lancet, 2018, 392 (10144): 312-358.

  2. Ministerio de Salud y Protección Social, Colombia, “Informe de evento vih7sida, Colombia, 2017”. Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/ VIH-SIDA%202017.pdf; 2018 (fecha de consulta: 26 de abril de 2019).

  3. Instituto Nacional de Salud de Colombia, Boletín Epidemiológico Semanal, semana 52, del 23 al 29 de diciembre de 2018. Disponible en: https://www.ins.gov. co/buscadoreventos/BoletinEpidemiologico/2018%20 Bolet%C3%ADn%20epidemiol%C3%B3gico%20semana% 2052.pdf (fecha de consulta: 28 de octubre de 2019).

  4. Osorio-Pinzón, J., Pinzón-Tovar, A., Vargas-Plazas, H.I., Barreto-Mora, J., Muñoz-Delgado, D.Y., Santana-Velasco, D. et al., “Perfil hormonal, metabólico y hematológico en adultos con el virus de inmunodeficiencia humana”, Rev Uni Ind Santander, 2018, 50 (4): 296-306.

  5. Laguado, L.D., Arenas, M., Rodríguez, R.M., Gómez, J., Bonilla, R.A. y Rojas, G., “Parámetros hematológicos y recuento de células t-cd4+ en pacientes vih con síntomas digestivos en Bucaramanga, Colombia”, Rev Cuba de Hematol Inmunol y Hemoter, 2016, 32 (4).

  6. Mathews, S.E., Srivastava, D., Balayadav, R. y Sharma, A., “Association of hematological profile of human immunodeficiency virus-positive patients with clinicoimmunologic stages of the disease”, J Lab Physicians, 2013, 5 (1): 34-37.

  7. Montúfar, F., Quiroga, A., Builes, C., Saldarriaga, C., Aguilar, C., Mesa, M. et al., “Epidemiología de la infección por el virus de inmunodeficiencia humana en pacientes hospitalizados en una institución de alta complejidad y enseñanza universitaria en Medellín”, Infectio, 2016, 20 (1): 9-16.

  8. Instituto Nacional de Salud, “Una mirada hacia el comportamiento de la tuberculosis en Colombia”, Boletín Epidemiológico Semanal, 2018. Disponible en: https://www.ins.gov. co/buscadoreventos/BoletinEpidemiologico/2018%20 Bolet%C3%ADn%20epidemiol%C3%B3gico%20semana% 2038.pdf (fecha de consulta: 10 de junio de 2019).

  9. Evans, R.H. y Scadden, D.T., “Hematological aspects of hiv infection”, Baillieres Best Pract Res Clin Haematol, 2000, 13 (2): 215-230.

  10. De Santis, G.C., Brunetta, D.M., Vilar, F.C., Brandão, R.A., De Albernaz Muniz, R.Z., De Lima, G.M. et al., “Hematological abnormalities in hiv-infected patients”, Int J Infect Dis, 2011, 15 (12): e808-811.

  11. Pande, A., Bhattacharyya, M., Pain, S. y Samanta, A., “Study of bone marrow changes in antiretroviral naive human immunodeficiency virus-infected anemic patients”, Indian J Pathol Microbiol, 2011, 54 (3): 542-546.

  12. Agus Somia, I.K., Merati, T.P., Bakta, I.M., Putra Manuaba, I.B., Yasa, W.P.S., Sukrama, I.D.M. et al., “High levels of serum il-6 and serum hepcidin and low cd4 cell count were risk factors of anemia of chronic disease in hiv patients on the combination of antiretroviral therapy”, hiv aids (Auckl), 2019, 11: 133-139.

  13. Tefferi, A., “Anemia in adults: a contemporary approach to diagnosis”, Mayo Clin Proc, 2003, 78 (10): 1274-1280.

  14. Ngongondo, M., Rosenberg, N.E., Stanley, C.C., Lim, R., Ongubo, D., Broadhurst, R. et al., “Anemia in people on second line antiretroviral treatment in Lilongwe, Malawi: a cross-sectional study”, bmc Infect Dis, 2018, 18 (1): 39.

  15. Bernal, F., Vásquez, P., Giadalah, C., Rodríguez, L. y Villagrán, A., “Incidencia de reacciones adversas a medicamentos en pacientes que inician o cambian terapia antirretroviral”, Rev Chilena Infectol, 2013, 30 (5): 507-512.

  16. Rajesh, R., Vidyasagar, S., Varma, D.M., Mohiuddin, S. y Noorunnisa, “Evaluation of incidence of zidovudine induced anemia in Indian human immunodeficiency virus positive patients in comparison with stavudine based highly active antiretroviral therapy”, Int J Risk Saf Med, 2011, 23 (3): 171-180.




2020     |     www.medigraphic.com