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2020, Number 4

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Rev Cubana Invest Bioméd 2020; 39 (4)

Importance of the optical mapping of HL-1 cardiomyocyte cultures in electrophysiological studies

Tobón C, Ugarte JP, Palacio LC

Language: Spanish
References: 37
Page: 1-20
PDF size: 394.15 Kb.


ABSTRACT

Introduction: The development of tools to study cardiac electrophysiological activity has made it possible to broaden knowledge about the mechanisms underlying cardiac arrhythmias. Optical mapping systems constitute a technology that responds to the need to overcome several hurdles in experimentation.
Objective: Provide an overview of the importance of optical mapping in HL-1 cell cultures in cardiac electrophysiology research.
Methods: A review was conducted of electrophysiological studies involving the HL-1 cell line using the optical mapping technique.
Conclusions: The studies are characterized by implementation of the technique with respect to the technology of mapping equipment, the use of different colorants and the purpose of the research. They focus on the study of arrhythmogenic mechanisms, mechanical stretch processes or tissue remodeling as well as the analysis of new biomaterials. The above substantiates the relevance of optical mapping in cardiac research.


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