Garnica EMA, Lemus SJ, Ramírez MBN, Tamez CEA, Marín LOM

Language: Spanish
References: 20
Page: 194-199
PDF size: 212.00 Kb.

ABSTRACT

Burn injury is often referred to as the most severe form of trauma in relation to the high metabolic response it generates because it can be perpetuated and remain elevated even up three years after the injury has resolved. Metabolic alterations are complex due to various mechanisms involved (metabolic, hormonal, inflammatory and genetic). Currently there are several mechanisms implemented in order to try to stop this hypermetabolic response. The purpose of this article is to inform medical personnel, which are the main causes of hypermetabolism and management strategies that exist in the treatment of severe burn.

REFERENCES

1. Porter C, Tompkins RG, Finnerty CC, Sidossis SL, Suman EO, Herndon ND. The metabolic stress response to burn trauma: current understanding and therapies. Lancet. 2016;388:1417-1426.

2. Jeschke MG. Post-burn hypermetabolism: past, present and future. J Burn Care Res. 2016;37:86-96.

3. Fagan SP, Bilodeau ML. Burn intensive care. J Burn Care Res. 2016;37:86-96.

4. Bilodeau PA, Coyne ES, Wing SS. The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation. Am J Physiol Cell Physiol. 2016;311:392-403.

5. Zamudio AJ, Peña RM, Riesgo EJ. La ubiquitinación: un sistema de regulación dinámico de los organismos. Rev Esp Cienc Quím-Biol. 2012;15:133-141.

6. Cree MG, Wolfe RR. Postburn trauma insulin resistance and fat metabolism. Am J Physiol Endocrinol Metab. 2008;209:1-9.

7. Kraft R, Herndon DN, Finnerty CC, Hiyama Y, Jeschke MG. Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children. J Clin Endocrinol Metab. 2013;98:314-321.

8. Rehou S, Mason S, Burnett M, Jeschke M. Burned adults develop profound glucose intolerance. Crit Care Med. 2016;44:1059-1066.

9. Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP. Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med. 2002;30:2438-3442.

10. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1:785-789.

11. Moreiraa E, Burghiby G, Manzanares W. Metabolismo y terapia nutricional en el paciente quemado crítico: una revisión actualizada. Med Intensiva. 2018;42(5):306-316. www.elsevier.es/medintensiva

12. Evidence-Based Guidelines Group ABA. Practice guidelines for burn care. J Burn Care Rehabil. 2001;22:59-66.

13. García de Lorenzo y Mateos A, Ortiz Leyba C, Sánchez Sánchez SM. Recomendaciones para el soporte nutricional y metabólico especializado del paciente crítico. Actualización. Consenso SEMICYUC-SENPE: paciente quemado crítico. Med Intensiva.2011;35:63-67.

14. Rimdeika R, Gudaviciene D, Adamonis K, Barauskas G, Pavalkis D, Endzinas Z. The effectiveness of caloric value of enteral nutrition in patients with major burns. Burns. 2006;32:83-86.

15. Dickerson RN, Gervasio JM, Riley ML, et al. Accuracy of predictive methods to estimate resting energy expenditure of thermally injured patients. JPENJ Parenter Enteral Nutr. 2002;26:17-29.

16. Abdullahi A, Jeschke MG. Nutrition and anabolic pharmacotherapies in the care of burn patients. american society for parenteral and enteral nutrition. Nutr Clin Pract. 2014;29(5):621-630.

17. Jeschke MG, Barrow RE, Herndon DN. Insulin like growth factor I plus insulin like growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children. Ann Surg. 2000;231:246-252.

18. Jeschke MG, Herndon DN, Wolf SE, et al. Recombinant human growth hormone alters acute phase reactant proteins, cytokine expression, and liver morphology in burned rats. J Surg Res. 1999;83:122-129.

19. Takala J, Ruokonen E, Webster NR, et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 1999;341:785-792.

20. Núñez VT, Sánchez M, Millán P, García LA. Revisión sistemática del efecto del propranolol sobre el hipermetabolismo del quemado. Med Intensiva. 2015;39:101-113.