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Colegio de Medicina Interna de México.

2021, Number 4

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Med Int Mex 2021; 37 (4)

Hypereosinophilia and increased IgE: atypical manifestations of primary cutaneous peripheral T-cell lymphoma

González-Sánchez V, Ku-Macedo A, Gaytán-Robles U

Language: Spanish
References: 16
Page: 636-641
PDF size: 248.89 Kb.


ABSTRACT

Background: Primary cutaneous peripheral T-cell lymphoma not otherwise specified is a heterogeneous group that includes all T cell neoplasms that do not fit into any of the best-defined subtypes in the WHO-EORTC classification. It represents only about 2-6% of primary cutaneous lymphomas and exhibits an aggressive behavior and unfavorable prognosis, and its diagnosis is usually delayed several years due to the non-specific histopathological and immunohistochemical findings, especially in the initial biopsies, so it represents a diagnostic challenge.
Clinical case: A 36-year-old male patient with primary cutaneous peripheral T-cell lymphoma not otherwise specified whose diagnosis was masked by the presence of hypereosinophilia and IgE elevation, confirmed after 7 years.
Conclusions: Due to the rarity of cases, unspecified primary cutaneous peripheral T-cell lymphoma is a disease that to date is not well understood and, consequently, algorithms for its diagnosis and treatment are lacking.


REFERENCES

  1. Willemze R, Cerroni L, Kempf W, Berti E, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood 2019; 133 (16): 1703-1714. doi. 10.1182/blood-2018-11-881268.

  2. Dewar R, Andea A, Guitart J, Arber D, et al. Best practices in diagnostic immunohistochemistry: Workup of cutaneous lymphoid lesions in the diagnosis of primary Cutaneous Lymphoma. Arch Pathol Lab Med 2015; 139 (3): 338-350. doi. 10.5858/arpa.2014-0018-CP.

  3. Zing NPC, Fischer T, Zain J, Federico M, et al. Peripheral T-cell lymphomas: incorporating new developments in diagnostics, prognostication, and treatment into clinical practice-PART 1: PTCL-NOS, FTCL, AITL, ALCL. Oncology (Williston Park) 2018; 32 (7): e74-e82.

  4. Su C, Nguyen KA, Bai HX, Cao Y, et al. Disease site as a determinant of survival outcome in patients with primary cutaneous peripheral T cell lymphoma, unspecified: an analysis of 4057 cases from the US National Cancer Database. Leuk Lymphoma 2018; 59 (9): 2105-2112. doi. 10.1080/10428194.2017.1410886.

  5. Lee MH, Choi ME, Won CH, Chang SE, et al. Comparative clinicopathologic analysis of cutaneous peripheral T-cell lymphoma, not otherwise specified, according to primary tumor site. J Am Acad Dermatol 2019; 80 (6): 1771-1774. doi. 10.1016/j.jaad.2018.09.051.

  6. Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, et al. Peripheral T-cell lymphoma, not otherwise specified (PTCLNOS). Cancer Treat Res 2019; 176: 83-98.

  7. Obara K, Mii S, Amoh. A case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified with cytotoxic phenotype showing multiple ulcers on the entire body. J Cutan Pathol. 2019; 46 (2): 148-151. doi. 10.1111/ cup.13386.

  8. Willemze R. CD30-Negative cutaneous T-cell lymphomas other tan mycosis fungoides. Surg Pathol Clin 2014; 7 (2): 229-52. doi. 10.1016/j.path.2014.02.006.

  9. Guinat M, Rusca M, Stalder M, Praz G. Eosinophilia: from neoplastic disease to anguillulosis. Rev Med Suisse 2014; 10 (445): 1853-4, 1856-8.

  10. Tancréde-Bohin E, Ionescu MA, De La Salmoniére P, Dupuy A, et al. Prognostic value of blood eosinophilia in primary cutaneous T-cell lymphomas. Arch Dermatol 2004; 140 (9): 1057-61. doi. 10.1001/archderm.140.9.1057.

  11. Jaque A, Mereniuk A, Sade S, Lansang P, et al. Eosinophils in the skin- a red herring masking lymphoma: a case series. SAGE Open Med Case Rep 2018; 6: 2050313X18773127. doi. 10.1177/2050313X18773127.

  12. Suga H, Sugaya M, Miyagaki T, Ohmatsu H, et al. Association of nerve growth factor, chemokine (C-C motif) ligands and immunoglobulin E with pruritus in cutaneous T-cell lymphoma. Acta Derm Venereol 2013; 93 (2): 144-9. doi. 10.2340/00015555-1428.

  13. Scala E, Abeni D, Palazzo P, Liso M, et al. Specific IgE toward allergenic molecules is a new prognostic marker in patients with Sézary syndrome. Int Arch Allergy Immunol 2012; 157 (2): 159-67. h ttps://doi.org/10.1159/000327553.

  14. Dippel E, Assaf C, Becker JC, von Bergwelt-Baildon M, et al. S2k Guidelines-Cutaneous Lymphomas Update 2016 - Part 2: Treatment and Follow-up (ICD10 C82 - C86). J Dtsch Dermatol Ges 2018; 16 (1): 112-122. doi. 10.1111/ddg.13401.

  15. Tolkachjov SN, Weenig RH, Comfere NI. Cutaneous peripheral T-cell lymphoma, not otherwise specified: A singlecenter prognostic analysis. J Am Acad Dermatol 2016; 75 (5): 992-999. doi. 10.1016/j.jaad.2016.06.011.

  16. Carton de Tournai D, Deschamps L, Laly P, Zeboulon C, et al. Granulomatous slack skin associated with metastatic testicular seminoma. Ann Dermatol Venereol 2017; 144 (6-7): 446-449. doi. 10.1016/j.annder.2017.03.010.




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