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2001, Number 4

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Rev Endocrinol Nutr 2001; 9 (4)

Homocysteine and vascular disease in diabetes mellitus type 2

Hernández LV, Toledo BI, Sánchez ÁF, López LG, Vadillo BM

Language: Spanish
References: 66
Page: 170-175
PDF size: 114.28 Kb.


ABSTRACT

Homocysteine is an intermediate product of cysteine metabolism; it forms by demethylation of methionine and eliminated by remethylation and transsulfuration pathway, both reactions dependent of B12 and B6 vitamin. It contains a thiol group that it is capable of reacting with other biologically important molecules. Hyperhomocysteinemia is a risk factor to vascular disease and is related with insulin secretion in diabetic type 2 patients. The mechanisms by which homocysteine may exert vascular injury are unclear but, even a minimal concentration, reduces endothelial vasodilator response, produces a cascade of inflammatory mediators and increases the expression of the final products of the enzymatic glycation receptors; all of these reaction could lead to loss the function of enzyme, receptors, growth factors and structural proteins.


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