García-Salcedo JJ, Batarse-Bandak J, Serrano-Gallardo LB, Rivera-Guillén MA

Language: Spanish
References: 17
Page: 8-12
PDF size: 127.36 Kb.

ABSTRACT

The objective of this study was to determine serum albumin concentration in hospital impatients and its relationship with the pathology, age and clinical evolution. The prospective study was carried out in 344 patients that were split into "elderly" and "non elderly" groups. This study demonstrated a clear relationship between an increasing number of pathologies, decrease of serum albumin and inadequate evolution. The elderly groups had higher prevalence of hypoalbuminemia, even without the presence of related poly-pathology. Albumin levels equal to or above 3.1 g/dL were generally associated with an adequate clinical outcome; albumin levels between 3.0 to 2.5 g/dL, 2.4 to 2.0 g/dL, 1.9 to 1.5 g/dL, 1.4 to 1.0 g/dL, and ‹ 0.9 g/dL had mortality rates of 26%, 60%, 81, 92% and 100.0% respectively. This study demonstrates that albumin levels are lower in the elderly and were associated with repeated occurrence of pathological conditions, pathology aggravation and/or low food intake conditioned by familiar collapse.

REFERENCES

1. Guyton AC, Hall JE. Tratado de Fisiología Médica. 10ª ed. México:Editorial Interamericana Mc Graw Hill; 2000.

2. Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL(eds.). Harrison Principios de Medicina Interna. 14ª ed. México:Editorial Interamericana Mc Graw Hill; 1998.

3. D’Erasmo E, Pisani. Serum albumin level at admission: mortality andclinical outcome in geriatrics patients. Am J Med Sci 1997; 314(1):17-20.

4. Abrams WB, Berkow R (eds.). El Manual Merck de Geriatría. Barcelona:Ediciones Doyma; 1992. p.334, 648-650.

5. Kane RL, Ouslander JG, Abrass IB. Essentials of Clinical Geriatrics.Third edition. New York: Editorial McGraw Hill; 1994. p.61.

6. Huidobro A, Velasco N. Prevalence of calorie protein malnutritionamong patients in chronic hemodialysis. Rev Med Chil 2001; 129(5):495-502.

7. Alonso Martínez JL, Abinzano Guillen ML. Morbidity and mortalityamong the hospitalized aged. Identification of prognostic factors.Ann Med Interna 1995; 12(9): 420-4.

8. Neyra NR, Hakim RM. Serum transferrin and serum prealbumin are earlypredictors of serum albumin in chronic hemodialysis patients. J RenNutr 2000; 10 (4): 184-90.

9. Salive ME, Cornoni-Huntley J. Serum albumin in older persons:relationship with age and health status. J Clin Epidemiol 1992; 45(3):213-21.

10. Gibbs JW, Cull W, Henderson W, Daley J, Hur K, Khuri SF. Preoperativeserum albumin level as a predictor of operative mortality and morbidity:results from the National VA Surgical Risk Study. Arch Surg 1999;134(1):36-42.

11. Marinella MA, Markert RJ. Admission serum albumin level and length ofhospitalization in elderly patients. South Med J 1998; 91(9): 851-4.

12. Tietz NW. Fundamentals of clinical chemistry. 2nd ed. Philadelphia: W.B.Saunders Co; 1986.

13. Sigma Stat for Windows version 1.0. Jandel Co. SPSS Science, USA,1994.

14. Harvey KB, Moldawer LL, Bistrian BR, Blackburn GL. Biological measuresfor the formulation of a hospital prognostic index. Am Clin Nutr 1981;34(10): 2013-2022.

15. Walter LC, Brand RJ, Counsell SR, Palmer RM, Landefeld CS, Fortinsky RH,et al Development and validation of a prognostic index for 1-year mortalityin older adults after hospitalization. JAMA 2001;285:2987-94.

16. Favela CJR, Castellano OM, Figueroa GV, Pérez SG, Gabilondo NF. Factorespronósticos en gangrena de Fournier. Rev Mex Urol 2002;61(2):58-61.

17. Tapia-Jurado J, Trueba-Pérez PA, Fajardo-Rodríguez AF. El valorpredictivo de la albúmina en el paciente quirúrgico con cáncer delaparato digestivo. Cirujano General (Méx) 2001;23:290-295.