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2020, Number 3

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Revista Cubana de Cirugía 2020; 59 (3)

Heyde Syndrome

Céspedes RHA, Céspedes RHR, Fernández PR

Language: Spanish
References: 10
Page: 1-7
PDF size: 335.28 Kb.


ABSTRACT

Introduction: Heyde syndrome is the association between aortic valve stenosis and gastrointestinal bleeding, due to intestinal angiodysplasia. The pathophysiological basis of this syndrome seems to be acquired Von Willebrand factor deficiency, which leads to bleeding from angiodysplastic arteriovenous malformations. Management alternatives include localization of bleeding points and cauterization, but such a therapeutic option is associated with high recurrence. Valve replacement seems to offer the best hope for long-term solving of bleeding and should be considered for most of the cases.
Objectives: To present a case of Heyde syndrome, a rare cause of gastrointestinal bleeding.
Clinical case: A 74-year-old patient is presented with a history of aortic stenosis and gastrointestinal bleeding due to duodenal angiodysplasia located in the second portion of it, managed by sclerotherapy.
Conclusions: Heyde syndrome is a rare association between aortic valve disease and digestive bleeding due to angiodysplasia that can occur in any part of the digestive tract.


REFERENCES

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  6. Veyradier A, Balian A, Wolf M, Giraud V, Montembault S, Obert B, et al. Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract. Gastroenterology. 2001;120:346-53.

  7. Vincentelli A, Susen S, Le Tourneau T, Six I, Fabre O, Juthier F, et al. Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med. 2003;349(4):343-9.

  8. Thompson JL, Schaff HV, Dearani JA, Park SJ, Sundt TM, Suri RM, et al. Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome. J Thorac Cardiovasc Surg. 2012;144(1):112-6.

  9. Godino C, Lauretta L, Pavon AG, Mangieri A, Viani G, Chieffo A, et al. Heyde's syndrome incidence and outcome in patients undergoing transcatheter aortic valve implantation. J Am Coll Cardiol. 2013;61(6):687-9.

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