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2020, Number 3

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Rev Cubana Cardiol Cir Cardiovasc 2020; 26 (3)

Neutrophil-lymphocyte index value in the diagnosis of type 4a infarction in patients with acute coronary syndrome

Rodríguez BS, Leyva QAY, Aguilar MJM, Barcelay LF, Collazo PM, Hernández VE

Language: Spanish
References: 15
Page: 1-6
PDF size: 299.51 Kb.


ABSTRACT

Introduction: The neutrophil-lymphocytary index has been proposed as an emerging inflammatory marker of cardiovascular risk. Objective: To evaluate the association between the neutrophil-lymphocytary index and the emergence of type 4a myocardial infarction in patients with acute coronary syndrome, as well as the potential diagnostic value of this biological marker. Method: Descriptive-correlational and prospective study to evaluate diagnostic value. Sample of 55 consecutive patients with acute coronary syndrome without ST elevation who underwent coronary intervention at ¨Hermanos Ameijeiras¨ Hospital over a period of 4 months. Basal blood sample and 6 hours after procedure sample were analyzed. Clinical, angiographic and procedure depending variables were studied. Results: It was found a significant increase in the post-proceeding INL (baseline: 3,316 [2,999-4,001] and after 6 hours 3,878 [3,214-4,491], p = 0.003). The 4a type infarction occurred to 5 patients, (9.01%). In them, the neutrophil-lymphocytary index increased at 6 hours after proceeding (without infarction: 3,999 [3,012 - 4,098] VS with infarction: 4,691 [3,887 - 5,960], p = 0.01). It was found a moderate positive association between the index and the classic biomarkers in patients with 4a type infarction, CK-MB and troponin T. A neutrophil-lymphocytary index ≥ 3.5 is the value that is closest to the prediction of heart attack risk. 4th (AUC 0.502, p = 0.04; OR = 1.26 (1.02 - 1.96), p = 0.04). Conclusions: The increase in the neutrophil-lymphocytary index 6 hours after the procedure has high sensitivity, high specificity and high negative predictive value in the prediction of 4a type myocardial infarction.


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