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2020, Number 2

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Rev Cubana Cardiol Cir Cardiovasc 2020; 26 (2)

Acute heart failure during COVID-19. Pathophysiology

Obregón SÁG, Prohias JA, Pérez BA, Vila GEE

Language: Spanish
References: 104
Page: 1-13
PDF size: 473.13 Kb.


ABSTRACT

At the end of 2019, a group of patients suffering from pneumonia that by their characteristics resembled viral pneumonia was reported in Wuhan, Hubei, China. The infectious germ was quickly identified as a coronavirus called SARS CoV2 and the disease as COVIG 19. This new virus affects multiple organs, including the heart, causing in some cases acute cardiac damage and sometimes death. Several colleges of cardiology worldwide have spoken in medical consensus to guide diagnostic and therapeutic points of view in this new disease. The objective of this work is to make a review as exhaustive as possible to know the pathophysiology of acute heart failure and cardiogenic shock as its most severe expression and the alterations it causes at the level of all organs, a fundamental element in trying to prevent or treat once it is established. Method. We did a comprehensive review of the literature by reviewing important databases such as Medline, Pubmed, Scielo, Cochrane, National Institute for Health and Care Excellence (NICE) and others. In addition, we reviewed randomized and controlled clinical trials, systematic review of controlled clinical trials, meta-analysis and high-quality cohort study, as well as observational study and systematic review of observational studies, from January 2010 to March 2020. Results: after an analysis to include and exclude research papers, a total of 270 relevant articles were found. Most of the excluded articles did not contain conclusive information regarding the criteria for acute heart failure, cardiogenic shock and its pathophysiology. Conclusions. Knowing the alterations that occur in acute heart failure and cardiogenic shock as its most severe expression, allows us to know the impact it has on the different systems of our body, a fundamental action to try to prevent or treat this syndrome in time, and thereby decrease its high mortality.


REFERENCES

  1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Jan 24. pii: S0140-6736(20)30183-5. . https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext.

  2. Kobayashi T, Jung SM, Linton NM, Kinoshita R, Hayashi K, Miyama T, et al Communicating the Risk of Death from Novel Coronavirus Disease (COVID-19). J Clin Med. 2020 Feb 21;9(2). pii: E580. https://www.mdpi.com/2077-0383/9/2/580/htm

  3. Ki M, -nCoV TFF. Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Republic of Korea. Epidemiol Health. 2020 Feb 9: e2020007.

  4. Colucci W, Braunwald E. Fisiopatología de la insuficiencia cardiaca. En: Braunwald E, Tratado de Cardiología. Texto de Medicina Cardiovascular. 10ma edición. Barcelona: Elsevier-Saunder; 2016:614-643.

  5. Bocchi A, Arias A, Verdejo H, Diez M, Gómez E, Castro P, et al. The Reality of Heart Failure in Latin America. JACC. 2013; 62(11): 949-958.

  6. Speranza Sánchez M, A. Quintero A, Benavides Santos A, Paulino A , González B, Brenes Umaña CD, et al. Primer Consenso Centroamericano y El Caribe de Sociedades de Cardiología para el diagnóstico y manejo de la falla cardíaca clínica y El Registro Centroamericano y del Caribe de Falla Cardíaca. Rev. Costarric. Cardiol.2015; 17 (1-2):50-63.

  7. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Gonzalez-Juanatey et al. Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2016; 18:891–975.

  8. Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, et al. Euro Heart Failure Survey II (EHFSII): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 2006; 27:2725–2736.

  9. Metra M, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, et al Effect of relaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes. J Am Coll Cardiol 2013; 61:196–206.

  10. Mebazaa A, Longrois D, Metra M, Mueller C, Richards AM, Roessig L, et al. Agents with vasodilator properties in acute heart failure: how to design successful trials. Eur J Heart Fail 2015; 17:652–664.

  11. Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014; 63:1123–1133.

  12. Veli-Pekka Harjola, Wilfried Mullens, Marek Banaszewski, Johann Bauersachs, Hans-Peter Brunner-La Rocca, Ovidiu Chioncel et al. Organ dysfunction, injury and failure in acute heart failure. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Journal of Heart Failure 2017; 19: 821–836.

  13. Nikolaou M, Parissis J, Yilmaz MB, Seronde MF, Kivikko M, Laribi S,et al . Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure. Eur Heart J 2013; 34:742–749.

  14. RoncoC, HaapioM, HouseAA, AnavekarN, BellomoR. Cardiorenal syndrome. J Am Coll Cardiol 2008; 52:1527–1539.

  15. Ronco C, McCullough P, Anker SD, Anand I, Aspromonte N, Bagshaw SM, et al. Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J 2010; 31:703–711.

  16. Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 2008; 134:172–178.

  17. Adams KF Jr, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2005; 149:209–216.

  18. Adamson PB, Magalski A, Braunschweig F, Bohm M, Reynolds D, Steinhaus D et al. Ongoing right ventricular hemodynamics in heart failure: clinical value of measurements derived from an implantable monitoring system. J Am Coll Cardiol 2003; 41:565–571.

  19. Zile MR, Bennett TD, St John SM, Cho YK, Adamson PB, Aaron MF, et al Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures. Circulation 2008; 118:1433–1441.

  20. Chaudhry SI, Wang Y, Concato J, Gill TM, Krumholz HM. Patterns of weight change preceding hospitalization for heart failure. Circulation 2007; 116:1549–1554.

  21. Mehta RH, Rogers JG, Hasselblad V, Tasissa G, Binanay C, Califf RM, et al Association of weight change with subsequent outcomes in patients hospitalized with acute decompensated heart failure. Am J Cardiol 2009; 103:76–81.

  22. Fallick C, Sobotka PA, Dunlap ME. Sympathetically mediated changes in capacitance: redistribution of the venous reservoir as a cause of decompensation. Circ Heart Fail 2011; 4:669–675.

  23. Mullens W, Abrahams Z, Skouri HN, Francis GS, Taylor DO, Starling RC, et al. Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function? J Am Coll Cardiol 2008; 51:300–306.

  24. Verbrugge FH, DupontM, SteelsP, GrietenL, MalbrainM, TangWH, et al Abdominal contributions to cardiorenal dysfunction in congestive heart failure. J Am Coll Cardiol 2013; 62:485–495. 19.

  25. Chioncel O, Ambrosy AP, Bubenek S, Filipescu D, Vinereanu D, Petris A, et al Epidemiology, pathophysiology, and in-hospital management of pulmonary edema: data from the Romanian Acute Heart Failure Syndromes registry. J Cardiovasc Med (Hagerstown) 2016; 17:92–104.

  26. Karim F. Changes in abdominal vascular capacity in response to stimulation of efferent sympathetic nerves. J Physio 1974; 239:26P–27P.

  27. MullensW, AbrahamsZ ,FrancisGS, TaylorDO, StarlingRC ,TangWH et al .Prompt reduction in intra-abdominal pressure following large-volume mechanical fluid removal improves renal insufficiency in refractory decompensated heart failure. J Card Fail 2008; 14:508–514.

  28. Aissaoui N, Puymirat E, Tabone X, Charbonnier B, Schiele F, Lefevre T et al. Improved outcome of cardiogenic shock at the acute stage of myocardial infarction: a report from the USIK 1995, USIC 2000, and FAST-MI French nationwide registries. Eur Heart J 2012; 33:2535–2543.

  29. Kolte D, Khera S, Aronow WS, Mujib M, Palaniswamy C, Sule S, et al . Trends in incidence, management, and outcomes of cardiogenic shock complicating ST-elevation myocardial infarction in the United States. J Am Heart Assoc 2014; 3:e000590.

  30. Gheorghiade M, Follath F, Ponikowski P, Barsuk JH, Blair JE, Cleland JG, et al Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine. Eur J Heart Fail 2010; 12:423–433.

  31. Harjola VP, Lassus J, Sionis A, Kober L, Tarvasmaki T, Spinar J, et al. Clinical picture, and risk prediction of short-term mortality in cardiogenic shock. Eur J Heart Fail 2015; 17:501–509.

  32. Rudiger A. Understanding cardiogenic shock. Eur J Heart Fail 2015; 17:466–467.

  33. Calfee CS, Matthay MA. Clinical immunology: culprits with evolutionary ties. Nature 2010; 464:41–42.

  34. Hochman JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003; 107:2998–3002.

  35. Nijst P, Verbrugge FH, Grieten L, Dupont M, Steels P, Tang WH, et al The pathophysiological role of interstitial sodium in heart failure. J Am Coll Cardiol 2015; 65:378–388.

  36. Marti CN, Gheorghiade M, Kalogeropoulos AP, Georgiopoulou VV, Quyyumi AA, Butler J. Endothelial dysfunction, arterial stiffness, and heart failure. J Am Coll Cardiol 2012; 60:1455–1469.

  37. Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, et al. The assessment of endothelial function: from research into clinical practice. Circulation 2012; 126:753–767.

  38. Gutierrez E, Flammer AJ, Lerman LO, Elizaga J, Lerman A, Fernandez-Aviles F. Endothelial dysfunction over the course of coronary artery disease. Eur Heart J 2013; 34:3175–3181.

  39. Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation 2005; 111:310–314.

  40. Shechter M, Matetzky S, Arad M, Feinberg MS, Freimark D. Vascular endothelial function predicts mortality risk in patients with advanced ischemic chronic heart failure. Eur J Heart Fail 2009; 11:588–593.

  41. Parrinello G, Greene SJ, Torres D, Alderman M, Bonventre JV, Di PP, et al. Water and sodium in heart failure: a spotlight on congestion. Heart Fail Rev 2015; 20:13–24.

  42. Volpe M, Carnovali M, Mastromarino V. The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment. Clin Sci (Lond) 2016; 130:57–77.

  43. Januzzi JL Jr, Filippatos G, Nieminen M, Gheorghiade M. Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section. Eur Heart J 2012; 33:2265–2271.

  44. Collins SP, Jenkins CA, Harrell FE Jr, Liu D, Miller KF, Lindsell CJ, et al Identification of emergency department patients with acute heart failure at low risk for 30-day adverse events: the STRATIFY Decision Tool. JACC Heart Fail 2015; 3:737–747.

  45. ThygesenK, AlpertJS, JaffeAS, SimoonsML, ChaitmanBR, WhiteHD, et al Third universal definition of myocardial infarction. Eur Heart J 2012; 33:2551–2567.

  46. Felker GM, Mentz RJ, Teerlink JR, Voors AA, Pang PS, Ponikowski P, et al Serial high sensitivity cardiac troponin T measurement in acute heart failure: insights from the RELAX-AHF study. Eur J Heart Fail 2015; 17:1262–1270.

  47. Pang PS, Teerlink JR, Voors AA, Ponikowski P, Greenberg BH, Filippatos G, et al. Use of high-sensitivity troponin t to identify patients with acute heart failure at lower risk for adverse outcomes: an exploratory analysis from the RELAX-AHF Trial. JACC Heart Fail 2016; 4:591–599. 42.

  48. Ware LB, Matthay MA. Clinical practice. Acute pulmonary edema. N Engl J Med 2005; 353:2788–2796.

  49. ScherrerU, RexhajE, JayetPY, AllemannY, SartoriC. New insights in the pathogenesis of high-altitude pulmonary edema. Prog Cardiovasc Dis 2010; 52:485–492.

  50. Busl KM, Bleck TP. Neurogenic pulmonary edema. Crit Care Med 2015; 43:1710–1715.

  51. Miyazawa R, Morita Y, Okajima Y, Matsusako M, Kurihara Y. Marathon-induced pulmonary edema of a patient with transient dyspnea. Jpn J Radiol 2015; 33:675–677.

  52. Ritter S, Rudiger A, Maggiorini M. Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational study. Crit Care 2009;13: R133. 47.

  53. Guazzi M, Phillips SA, Arena R, Lavie CJ. Endothelial dysfunction and lung capillary injury in cardiovascular diseases. Prog Cardiovasc Dis 2015; 57:454–462.

  54. Guglin M, Khan H. Pulmonary hypertension in heart failure. J Card Fail 2010; 16:461–474.

  55. Agostoni P, Cattadori G, Bussotti M, Apostolo A. Cardiopulmonary interaction in heart failure. Pulm Pharmacol Ther 2007; 20:130–134.

  56. Tanabe T, Rozycki HJ, Kanoh S, Rubin BK. Cardiac asthma: new insights into an old disease. Expert Rev Respir Med 2012; 6:705–714.

  57. Damman K, Valente MA, Voors AA, O’Connor CM, van Veldhuisen DJ, Hillege HL et al. Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. Eur Heart J 2014; 35:455–469.

  58. Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol 2009; 53:589–596.

  59. Nohria A, Tsang SW, Fang JC, Lewis EF, Jarcho JA, Mudge GH, et al. Clinical assessment identifies hemodynamic profiles that predict outcomes in patients admitted with heart failure. J Am Coll Cardiol 2003; 41:1797–1804.

  60. Mullens W, Nijst P. Cardiac output and renal dysfunction: definitely more than impaired flow. J Am Coll Cardiol 2016; 67:2209–2212.

  61. HanbergJS, SuryK, WilsonFP, BriscoMA, AhmadT, terMaatenJM, et al. Reduced cardiac index is not the dominant driver of renal dysfunction in heart failure. J Am Coll Cardiol 2016; 67:2199–2208. 56.

  62. Legrand M, Mebazaa A, Ronco C, Januzzi JL Jr. When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome. Crit Care Med 2014; 42:2109–2117.

  63. Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, et al. A. Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Clin Res Cardiol 2016; 105:971–980.

  64. Kidney Disease Improving Global Outcomes (KDIGO) Working Group. KDIGO clinical practice guidelines for acute kidney injury. Kidney Int Suppl 2012; 2:1–138.

  65. Hsu CY, Ordonez JD, Chertow GM, Fan D, McCulloch CE, Go AS. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int 2008; 74:101–107.

  66. Metra M, Nodari S, Parrinello G, Bordonali T, Bugatti S, Danesi R, et al. Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significance. Eur J Heart Fail 2008; 10:188–195.

  67. Lassus JP, Nieminen MS, Peuhkurinen K, Pulkki K, Siirila-Waris K, Sund R, et al. Markers of renal function and acute kidney injury in acute heart failure: definitions and impact on outcomes of the cardiorenal syndrome. Eur Heart J 2010; 31:2791–2798.

  68. Damman K, Tang WH, Testani JM, McMurray JJ. Terminology and definition of changes in renal function in heart failure. Eur Heart J 2014; 35:3413–3416.

  69. . Damman K, Testani JM. The kidney in heart failure: an update. Eur Heart J 2015; 36:1437–1444.

  70. Valenta MA, Voors AA, Damman K, van Veldhuisen DJ, Massie BM, O’Connor CM, et al. Diuretic response in acute heart failure: clinical characteristics and prognostic significance. Eur Heart J 2014; 35:1284–129.

  71. Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential effects of aggressive decongestion during the treatment of decompensated heart failure on renal function and survival. Circulation 2010; 122:265–272.

  72. Brisco MA, Zile MR, Hanberg JS, Wilson FP, Parikh CR, Coca SG, et al. Relevance of changes in serum creatinine during a heart failure trial of decongestive strategies: insights from the DOSE Trial. J Card Fail 2016; 22:753–760.

  73. . Ambrosy AP, Vaduganathan M, Huffman MD, Khan S, KwasnyMJ, Fought AJ, et al. Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial. Eur J Heart Fail 2012; 14:302–311.

  74. Auer J. What does the liver tell us about the failing heart? Eur Heart J 2013; 34:711–714.

  75. BiegusJ, HillegeHL, PostmusD, ValenteMA, BloomfieldDM, ClelandJG et al P. Abnormal liver function tests inacute heart failure: relationship with clinical characteristics and outcome in the PROTECT study. Eur J Heart Fail 2016; 18:830–839.

  76. Nikolaou M, Parissis J, Yilmaz MB, Seronde MF, Kivikko M, Laribi S, et al. Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure. Eur Heart J 2013; 34:742–749.

  77. DrolzA, HorvatitsT, RoedlK, RutterK, StauferK, HaiderDG, et al. Outcome and features of acute kidney injury complicating hypoxic hepatitis at the medical intensive care unit. Ann Intensive Care 2016; 6:61.

  78. Kim MS, Kato TS, Farr M, Wu C, Givens RC, Collado E, et al. Hepatic dysfunction in ambulatory patients with heart failure: application of the MELD scoring system for outcome prediction. J Am Coll Cardiol 2013; 61:2253–2261.

  79. Poelzl G, Ess M, von der Heidt A, Rudnicki M, Frick M, Ulmer H et al. Concomitant renal and hepatic dysfunctions in chronic heart failure: clinical implications and prognostic significance. Eur J Intern Med 2013; 24:177–182.

  80. Parissis JT, Farmakis D, Andreoli C, Rafouli-Stergiou P, Ambrosio G, Anastasiou-Nana M, et al. Cardio–reno–hepatic interactions in acute heart failure: the role of 𝛾𝛾-glutamyl transferase. Int J Cardiol 2014; 173:556–557.

  81. Moller S, Bernardi M. Interactions of the heart and the liver. Eur Heart J 2013; 34:2804–2811.

  82. Samsky MD, Patel CB, DeWald TA, Smith AD, Felker GM, Rogers JG, et al. Cardiohepatic interactions in heart failure: an overview and clinical implications. J Am Coll Cardiol 2013; 61:2397–2405.

  83. Whitehead MW, Hawkes ND, Hainsworth I, Kingham JG. A prospective study of the causes of notably raised aspartate aminotransferase of liver origin. Gut 1999; 45:129–133.

  84. Fuhrmann V, Kneidinger N, Herkner H, Heinz G, Nikfardjam M, Bojic A, et al. Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients. Intensive Care Med 2009; 35:1397–1405.

  85. Fuhrmann V, Kneidinger N, Herkner H, Heinz G, Nikfardjam M, Bojic A, et al. Impact of hypoxic hepatitis on mortality in the intensive care unit. Intensive Care Med 2011; 37:1302–1310.

  86. Rogler G, Rosano G. The heart and the gut. Eur Heart J 2014; 35:426–430.

  87. Sandek A, Bauditz J, Swidsinski A, Buhner S, Weber-Eibel J, von Haehling S, et al. Altered intestinal function in patients with chronic heart failure. J Am Coll Cardiol 2007; 50:1561–1569.

  88. Valentova M, von Haehling S, Bauditz J, Doehner W, Ebner N, Bekfani T, et al Intestinal congestion and right ventricular dysfunction: a link with appetite loss, inflammation, and cachexia in chronic heart failure. Eur Heart J 2016; 37:1684–1691.

  89. Suzuki N, Kida K, Suzuki K, Harada T, Akashi YJ. Assessment of transthyretin combined with mini nutritional assessment on admission provides useful prognostic information in patients with acute decompensated heart failure. Int Heart J 2015; 56:226–233.

  90. Levin SN, Hajduk AM, McManus DD, Darling CE, Gurwitz JH, Spencer FA, Cognitive status in patients hospitalized with acute decompensated heart failure. Am Heart J 2014; 168:917–923.

  91. Leto L, Feola M. Cognitive impairment in heart failure patients. J Geriatr Cardiol 2014; 11:316–328.

  92. Sokoreli I, de Vries JJ, Pauws SC, Steyerberg EW. Depression and anxiety as predictors of mortality among heart failure patients: systematic review and meta-analysis. Heart Fail Rev 2016; 21:49–63.

  93. Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure: a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol 2006; 48:1527–1537.

  94. Davis KK, Mintzer M, Dennison Himmelfarb CR, Hayat MJ, Rotman S, Allen Je al. Targeted intervention improves knowledge but not self-care or readmissions in heart failure patients with mild cognitive impairment. Eur J Heart Fail 2012; 14:1041–1049.

  95. Inouye SK, Rushing JT, Foreman MD, Palmer RM, Pompei P. Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. J Gen Intern Med 1998; 13:234–242.

  96. Kindermann I, Fischer D, Karbach J, Link A, Walenta K, Barth C, et al. Cognitive function in patients with decompensated heart failure: The Cognitive Impairment in Heart Failure (CogImpair-HF) study. Eur J Heart Fail 2012; 14:404–413.

  97. Rihal CS, Naidu SS, Givertz MM, Szeto WY, Burke JA, Kapur NK, et al. 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care. J Am Coll Cardiol [Internet]. 2015;65(19): e7–e26. Available from: http://www.sciencedirect.com/science/article/pii/S0735109715008657

  98. Hochman JS, Buller CE, Sleeper LA, Boland J, Dzavik V, Sanborn TA, et al. Cardiogenic shock complicating acute myocardial infarction – Etiologies, management and outcome: A report from the SHOCK Trial Registry. J Am Coll Cardiol [Internet]. 2000;36(3 SUPPL. A):1063–70. Available from: http://dx.doi.org/10.1016/S0735-1097(00)00879-2.

  99. Thiele H, Ohman E, Waha-Thiele S de, Zeymer U, Desch S. Management of cardiogenic shock complicating myocardial infarction: an update 2019. Eur Heart J. 2019;40(32):2671–83.

  100. Baran D, Grines C, Bailey S, Burkhoff D, Hall S, Henry T, et al. SCAI clinical expert consensus statement on the classification of cardiogenic shock: This document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Societ. Catheter Cardiovasc Interv official. J Soc Card Angiogr Interv. 2019;94(1):29–37.

  101. Jentzer J, Diepen S van, Barsness G, Henry T, Menon V, Rihal C, et al. Cardiogenic Shock Classification to Predict Mortality in the Cardiac Intensive Care Unit. J Am Coll Cardiol. 2019;74:(17)

  102. Berg D, Bohula E, Diepen S van, Katz J, Alviar C, Baird-Zars V, et al. Epidemiology of Shock in Contemporary Cardiac Intensive Care Units. Circ Cardiovasc Qual Outcomes. 2019;12(3): e005618.

  103. Jentzer J, Baran D, Diepen S van, Barsness G, Henry T, Naidu S, et al. Admission Society for Cardiovascular Angiography and Intervention shock stage stratifies post-discharge mortality risk in cardiac intensive care unit patients. Am Heart J. 2019;27(219):37–46.

  104. van Diepen S, Katz J, NM NA, Henry T, Jacobs A, Kapur N, et al. Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation. 2017;136(16): e232–68.




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