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2021, Number 3

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Med Crit 2021; 35 (3)

Diaphragmatic dysfunction and ultrasonographic evaluation in critical illness

Garnica EMA, Carrillo ER, Ramales GJE, Marín LOM, Lemus SJ, Laredo SEC

Language: Spanish
References: 31
Page: 148-153
PDF size: 255.82 Kb.


ABSTRACT

The diaphragmatic dysfunction induced by mechanical ventilation is the clinical expression of the alterations generated by the inactivity of the diaphragm in conditions of invasive mechanical ventilation. Various molecular pathways and mechanisms explain atrophy and subsequently functional disability as an important cause of failure in extubation in the context of the critically ill patient. In this subgroup of patients there is a causal relationship of early onset of muscle dysfunction and ventilatory support and that is mainly related to the use of control modalities, the presence of sepsis and multiorgan failure. We reviewed the concepts about diaphragmatic dysfunction, the mechanisms involved in its appearance and the resources for early diagnosis to initiate a timely rehabilitation and positively influence the prognosis of these patients.


REFERENCES

  1. Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med. 2010;38:1947-1953.

  2. Jaber S, Jung B, Matecki S, Petrof BJ. Clinical review: ventilator-induced diaphragmatic dysfunction-human studies confirm animal model findings. Crit Care. 2011;15:206-211.

  3. Demoule A, Jung B, Prodanovic H, Molinari N, Chanques G. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013;14:213-219.

  4. Hermans G, Agten A, Testelmans D, Decramer M, Ramirez G. Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: A prospective observational study. Crit Care. 2010;14(4):R127.

  5. Hermans G, Van Mechelen H, Clerckx B. Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis. Am J Respir Crit Care Med. 2014;190(4):410-420.

  6. Jaber S, Petrof BJ, Jung B, Chanques G, Berthet J, Rabuel C. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med. 2011;2:364-371.

  7. Supinski GS, Callahan LA. Diaphragm weakness in mechanically ventilated critically ill patients. Crit Care. 2013;13:120-125.

  8. Powers SK, Kavazis AN, Levine S. Prolonged mechanical ventilation alters diaphragmatic structure and function. Crit Care Med. 2009;37(10 Suppl):S347-53.

  9. Levine S, Nguyen T, Taylor N, Friscia M, Budak MS. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008:1327-1335

  10. Powers SK, Wiggs MP, Sollanek KJ, Smuder AJ. Ventilator-induced diaphragm dysfunction: cause and effect. AJP Regul Integr Comp Physiol. 2013;2:464-477

  11. Shanely A, Zergeroglu MA, Lennon SL, Sugiura T, Yimlamai T, Enns D. Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med. 2002;166(10):1369-1374.

  12. Radell P, Edstrom L, Stibler H, Eriksson LI, Ansved T. Changes in diaphragm structure following prolonged mechanical ventilation in piglets. Acta Anaesthesiol Scand. 2004;48(4):430-437.

  13. Capdevila X, Lopez S, Bernard N, Sugiura T, Yimlamai T. Effects of controlled mechanical ventilation on respiratory muscle contractile properties in rabbits. Intensive Care Med. 2003;29:103-110.

  14. Zergeroglu MA, McKenzie MJ, Shanely RA, Van Gammeren D, Deruisseau KC. Mechanical ventilation-induced oxidative stress in the diaphragm. J Appl Physiol. 2003;93(3):1116-1124.

  15. Whidden AW, Smuder AJ, Wu M, Hudson MB, Nelson WB. Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm. J Appl Physiol. 2010;4:1376-1382.

  16. Malicdan MC, Noguchi S, I. Nonaka, P. Saftig, I. Nishino. Lysosomal myopathies: an excessive build-up in autophagosomes is too much to handle. Neuromuscul Disord. 2008;3:521-529.

  17. Tang H, Lee M, Khuong A, Wright E, Shrager JB. Diaphragm muscle atrophy in the mouse after long-term mechanical ventilation. Muscle Nerve. 2013;5:272-278.

  18. Testelmans D, Maes K, Wouters P, Gosselin N, Deruisseau K. Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats. Crit Care Med. 2006;3:3018-3023.

  19. Callahan LA, Supinski GS. Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress. Crit Care. 2014;5:88.

  20. Petrof BJ, Jaber S, Matecki S. Ventilator-induced diaphragmatic dysfunction. Curr Opin Crit Care. 2016;3:19-25.

  21. Watson AC, Hughes PD, Louise HM. Measurement of twitch transdiaphragmatic, esophageal, and endotracheal tube pressure with bilateral anterolateral magnetic phrenic nerve stimulation in patients in the Intensive Care Unit. Crit Care Med. 2001;13:25-31.

  22. Akoumianaki E, Maggiore SM, Valenza F, Bellani G, Jubran A, Loring S. The application of esophageal pressure measurement in patients with respiratory failure. Am J Respir Crit Care Med. 2014;6:520-531.

  23. Gilbert R, Auschincloss JH, Peppi D. Relationship of rib cage and abdomen motion to diaphragm function during quiet breathing. Chest. 1981;7:607-612.

  24. Kera T, Aihara A, Inomata T. Reliability of airway occlusion pressure as an index of respiratory motor output. Respir Care. 2013;6:845-849.

  25. Thiruppathi C. Weaning and extubation. J Lung Pulm Respir Res. 2015;2:40-43.

  26. Umbrello M, Formenti P, Longhi D, Galimberti A, Piva I, Pezzi A. Diaphragm ultrasound as indicator of respiratory effort in critically ill patients undergoing assisted mechanical ventilation: A pilot clinical study. Crit Care. 2015;3:1-10.

  27. Kim WY, Suh HJ, Hong SB, Koh Y, Lim CM. Diaphragm dysfunction assessed by ultrasonography: Influence on weaning from mechanical ventilation. Crit Care Med. 2011;4:2627-2630.

  28. Matamis D, Soilemezi E, Tsagourias M, Akoumianaki E, Dimassi. Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications. Intensive Care Med. 2013;39(5):801-810.

  29. Umbrello M, Formenti P, Longhi D, Galimberti A, Piva I, Pezzi A. Diaphragm ultrasound as indicator of respiratory effort in critically ill patients undergoing assisted mechanical ventilation: a pilot clinical study. Crit Care. 2015;19:16-25.

  30. Boussuges A, Gole Y, Blanc P. Diaphragmatic motion studied by M-mode ultrasonography. Chest. 2009;5:391-400.

  31. Schepens T, Verbrugghe W, Dams K, Corthouts B. The course of diaphragm atrophy in ventilated patients assessed with ultrasound: a longitudinal cohort study. Crit Care. 2015;4:422-428.




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