2004, Número s2
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Arch Cardiol Mex 2004; 74 (s2)
Los rotores y la fibrilación
Jalife J
Idioma: Español
Referencias bibliográficas: 24
Paginas: 289-292
Archivo PDF: 48.77 Kb.
RESUMEN
La generación de la fibrilación auricular o ventricular es todavía un extenso campo de discusión y de investigación en electrofisiología básica y clínica. Nuevas hipótesis acerca de la dinámica de propagación de ondas no lineales en medios excitables se enfocan hacia el papel que juegan los rotores en el mecanismo de la fibrilación y han dado lugar a dos corrientes de pensamiento. Una, propone una característica de inestabilidad y transitoriedad de los rotores y otra propone su fractura y su multiplicación en un medio de anisotropía estructural miocárdica. La integración del conocimiento de la dinámica de propagación de ondas no lineales, con las recientes aportaciones de la biología molecular y la biofísica de los canales iónicos es de una importancia indiscutible en el desarrollo futuro de una terapia antifibrilatoria.
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