2020, Número 2
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Rev Mex Mastol 2020; 10 (2)
Las propiedades epigenéticas y anticáncer del ácido valproico
Luna-Palencia GR, Fernández-Navarrete E, Vásquez-Moctezuma i
Idioma: Español
Referencias bibliográficas: 65
Paginas: 54-62
Archivo PDF: 213.74 Kb.
RESUMEN
El ácido valproico es un fármaco antiepiléptico que se ha utilizado por más de 50 años. Sin embargo, hace unas décadas se descubrió que posee efectos epigenéticos y este hallazgo permitió proponerlo como fármaco anticáncer. Existe amplia evidencia clínica acumulada en el uso de éste y sus efectos en el humano. El dato clínico y epidemiológico que indica su efecto en el cáncer es la observación de que el uso crónico en un grupo muy extenso de pacientes veteranos de guerra disminuye la frecuencia de cáncer de cabeza y cuello. También existen múltiples ensayos en líneas celulares de humano y modelos animales donde se observa un efecto de detención del ciclo celular, inducción de diferenciación y muerte. En esta revisión se analiza la aplicación de este fármaco en combinación con la quimioterapia.
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