2020, Número 08
<< Anterior Siguiente >>
Revista Médica Sinergia 2020; 5 (08)
Tumor de Klatskin en el adulto
González CA, Rivera FS, Chacón GC
Idioma: Español
Referencias bibliográficas: 26
Paginas: 1-9
Archivo PDF: 152.44 Kb.
RESUMEN
El colangiocarcinoma hiliar, comúnmente conocido como tumor de Klatskin,
es una neoplasia poco frecuente. Su etiopatogenia no es completamente
conocida, pero se encuentra una fuerte asociación entre la inflamación
crónica de la vía biliar, la colestasis y el desarrollo de colangiocarcinoma.
Los principales factores de riesgo son la colangitis esclerosante primaria,
las enfermedades fibroquísticas del hígado, infecciones hepáticas,
hepatolitiasis, drogas y toxinas. Este tumor se caracteriza por presentar un
cuadro clínico asintomático hasta estadíos avanzados. Su diagnóstico se
realiza por medio de laboratorios e imagenología. El tratamiento se basa
principalmente en cirugía, ya que no hay beneficios terapéuticos
demostrados con el uso de radiación y/o quimioterapia.
REFERENCIAS (EN ESTE ARTÍCULO)
Sharma P. Demographics, tumor characteristics, treatment, and survival of patients with Klatskin tumors. Annals of Gastroenterology. 2018;. https://doi.org/10.20524/aog.2018.0233
Melenhorst MCAM, Scheffer HJ, Vroomen LGPH, Kazemier G, van den Tol MP, Meijerink MR. Percutaneous Irreversible Electroporation of Unresectable Hilar Cholangiocarcinoma (Klatskin Tumor): A Case Report. CardioVascular and Interventional Radiology. 2015 05 21;39(1):117- 121. https://doi.org/10.1007/s00270-015-1126-z
Zhang X, Liu H. Klatskin Tumor: A Population-Based Study of Incidence and Survival. Medical Science Monitor. 2019 06 17;25:4503-4512. https://doi.org/10.12659/msm.914987
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RIR, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJG, Alvaro D. Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Nature Reviews Gastroenterology & Hepatology. 2016 04 20;13(5):261-280. https://doi.org/10.1038/nrgastro.2016.51
Andersen JB. Molecular pathogenesis of intrahepatic cholangiocarcinoma. Journal of Hepato-Biliary- Pancreatic Sciences. 2014 09 01;22(2):101-113. https://doi.org/10.1002/jhbp.155
Lindor KD, Kowdley KV, Harrison EM. ACG Clinical Guideline: Primary Sclerosing Cholangitis. American Journal of Gastroenterology. 2015 05;110(5):646-659. https://doi.org/10.1038/ajg.2015.112
Hadzic N, Strazzabosco M. Fibropolycystic Liver Diseases and Congenital Biliary Abnormalities. In: Dooley JS, Lok ASF, Garcia-Tsao G, Pinzani M, editors. Sherlock's Diseases of the Liver and Biliary System. Chichester, UK: Wiley 2018. p. 308-327. https://doi.org/10.1002/9781119237662.ch16
Xiong J, Wang Y, Huang H, Bian J, Wang A, Long J, Zheng Y, Sang X, Xu Y, Lu X, Zhao H. Systematic review and meta-analysis: cholecystectomy and the risk of cholangiocarcinoma. Oncotarget. 2017 07 26;8(35):59648-59657. https://doi.org/10.18632/oncotarget.19570
Lindor KD, Kowdley KV, Harrison EM. ACG Clinical Guideline: Primary Sclerosing Cholangitis. American Journal of Gastroenterology. 2015 05;110(5):646-659. https://doi.org/10.1038/ajg.2015.112
Sithithaworn P, Yongvanit P, Duenngai K, Kiatsopit N, Pairojkul C. Roles of liver fluke infection as risk factor for cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Sciences. 2014 01 10;21(5):301- 308. https://doi.org/10.1002/jhbp.62
Zhang H, Zhu B, Zhang H, Liang J, Zeng W. HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis. BioMed Research International. 2016;2016:1- 14. https://doi.org/10.1155/2016/3417976
Suk WA, Bhudhisawadi V, Ruchirawat M, The Curious Case of Cholangiocarcinoma: Opportunities for Environmental Health Scientists to Learn about a Complex Disease. J Environ Public Health. 2018;2018:1-7. https://doi.org/10.1155/2018/2606973
Addeo P, Jedidi I, Locicero A, Faitot F, Oncioiu C, Onea A, Bachellier P. Prognostic Impact of Tumor Multinodularity in Intrahepatic Cholangiocarcinoma. Journal of Gastrointestinal Surgery. 2018 Nov 26;23(9):1801-1809. https://doi.org/10.1007/s11605-018-4052-y
Bird N, Elmasry M, Jones R, Elniel M, Kelly M, Palmer D, Fenwick S, Poston G, Malik H. Role of staging laparoscopy in the stratification of patients with perihilar cholangiocarcinoma. British Journal of Surgery. 2016 Nov 08;104(4):418-425. https://doi.org/10.1002/bjs.10399
Horvat N, Nikolovski I, Long N, et al. Imaging features of hepatocellular carcinoma compared to intrahepatic cholangiocarcinoma and combined tumor on MRI using liver imaging and data system (LI RADS) version 2014. Abdom Radiol (NY).2018;43:169-178. https://doi.org/10.1007/s00261-017-1261-x
Valle J, Borbath I, Khan S, Huguet F, Gruenberger T, Arnold D. Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2016 09;27:v28- v37. https://doi.org/10.1093/annonc/mdw324
Hai-Jie Hu, Rong-Xing Zhou, Anuj Shestha, Yong-Qiong Tan. Relationship of tumor size with pathological and prognostic factors for hiliar cholangiocarcinoma. Oncotarget. 2017 Dec 1; 8(62): 105011-105019. https://doi.org/10.18632/oncotarget.22054
Groot Koerkamp B, Wiggers J, Gonen M, Doussot A, Allen P, Besselink M, Blumgart L, Busch O, D'Angelica M, DeMatteo R, Gouma D, Kingham T, van Gulik T, Jarnagin W. Survival after resection of perihilar cholangiocarcinoma—development and external validation of a prognostic nomogram. Annals of Oncology. 2016 04;27(4):753. https://doi.org/10.1093/annonc/mdw063
Rassam F, Roos E, van Lienden KP, van Hooft JE, Klümpen HJ, van Tienhoven G, Bennink RJ, Engelbrecht MR, Schoorlemmer A, Beuers UHW, Verheij J, Besselink MG, Busch OR, van Gulik TM. Modern work-up and extended resection in perihilar cholangiocarcinoma: the AMC experience. Langenbeck's Archives of Surgery. 2018 01 19;403(3):289- 307. https://doi.org/10.1007/s00423-018-1649-2
Hara K, Yamao K, Mizuno N, et al. Endoscopic ultrasonography-guided biliary drainage: Who, when, which, and how? World J Gastroenterol 2016;22:1297-303. doi: 10.3748/wjg.v22.i3.1297. https://doi.org/10.3748/wjg.v22.i3.1297
Kubota K, Hasegawa S, Iwasaki A, Sato T, Fujita Y, Hosono K, Nakajima A, Mori R, Matsuyama R, Endo I. Stent placement above the sphincter of Oddi permits implementation of neoadjuvant chemotherapy in patients with initially unresectable Klatskin tumor. Endoscopy International Open. 2016 03 30;04(04):E427-E433. https://doi.org/10.1055/s-0042-102246
Ivan Capobianco, Jens Rolinger, Silvio Nadalin. Resection for Klatskin tumors: technical complexities and results. Transl Gastroenterol Hepatol. 2018;3:69. https://doi.org/10.21037/tgh.2018.09.01
Michael E. Lidsky, William R. Jarnagin. Surgical management of hilar cholangiocarcinoma at Memorial Sloan Kattering Cancer Center. Ann Gastroneterol Surg 2018 Jul; 2(4): 304-312. https://doi.org/10.1002/ags3.12181
Grendar J, Grendarova P, Sinha R, Dixon E. Neoadjuvant therapy for downstaging of locally advanced hilar cholangiocarcinoma: a systematic review. HPB. 2014;16:297–303 https://doi.org/10.1111/hpb.12150
Wiggers JK, Groot Koerkamp B, Cieslak KP, Doussot A, van Klaveren D, Allen PJ, Besselink MG, Busch OR, D'Angelica MI, DeMatteo RP, Gouma DJ, Kingham TP, van Gulik TM, Jarnagin WR. Postoperative Mortality after Liver Resection for Perihilar Cholangiocarcinoma: Development of a Risk Score and Importance of Biliary Drainage of the Future Liver Remnant. Journal of the American College of Surgeons. 2016 08;223(2):321-331.e1. https://doi.org/10.1016/j.jamcollsurg.2016.03.035
Hoehn RS, Wima K, Ertel AE, Meier A, Ahmad SA, Shah SA, Abbott DE. Adjuvant Chemotherapy and Radiation Therapy is Associated with Improved Survival for Patients with Extrahepatic Cholangiocarcinoma. Annals of Surgical Oncology. 2015 05 15;22(S3):1133- 1139. https://doi.org/10.1245/s10434-015-4599-8