Godínez VAR, Carrillo ER, Cabello AR

Idioma: Español
Referencias bibliográficas: 27
Paginas: 156-159
Archivo PDF: 188.90 Kb.

RESUMEN

Introducción: Los neutrófilos son uno de los componentes celulares más importantes de la inmunidad innata, debido a que estas células se reclutan rápidamente a los sitios de infección y pueden eliminar patógenos por múltiples métodos. En diferentes entidades, de entre las que se destaca la sepsis, los neutrófilos mejoran sus propiedades antimicrobianas mediante la liberación de trampas extracelulares de neutrófilos (TEN), constituidas por cromatina, histonas y proteínas granulares, proceso que es conocido por NETosis.
Objetivo: El objetivo de esta revisión es examinar los conceptos actuales, relacionados con los mecanismos subyacentes de la formación de TEN y su impacto en sepsis.
Conclusión: La desregulación de la NETosis causada por sepsis puede tener efectos deletéreos en sepsis, destacando inflamación, trombosis y disfunción multiorgánica.

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