Roque-Fernández MÁ, González-Mirasol E, Álvarez-Lleó C, Sánchez-Toledo M, García-Garrido C, Amezcua-Recover A

Idioma: Español
Referencias bibliográficas: 28
Paginas: 740-746
Archivo PDF: 323.57 Kb.

RESUMEN

Objetivo: Evaluar si las concentraciones elevadas de progesterona el día de la captura de ovocitos influyen en el resultado del ciclo de fertilización in vitro.
Materiales y Métodos: Estudio de cohortes, prospectivo, de ciclos de FIVICSI, con protocolo agonista largo o antagonista y con transferencia de embriones en fresco en día 2-3. Se consideraron concentraciones elevadas de progesterona a las superiores al percentil 90. Variables analizadas: tasas de embarazo bioquímico (β-hCG positiva), clínico (embrión intrauterino vivo en semanas 6-7) y de abortos del primer trimestre.
Resultados: Se estudiaron 400 ciclos de FIV-ICSI, con protocolo agonista largo (n = 41) o antagonista (n = 359) y con transferencia de embriones en fresco en día 2-3. No se encontraron diferencias estadísticamente significativas en las tasas de embarazo cuando la progesterona excedió de 14 ng/mL (percentil 90), con porcentajes parecidos de embarazo bioquímico en ambos grupos (41 vs 40.2%). Si bien el porcentaje de embarazo clínico fue ligeramente menor en el grupo con elevación de la progesterona (30.8 vs 33.5%), también se observó mayor porcentaje de abortos (25.7 vs 43.8%) aunque estos resultados tampoco fueron significativos.
Conclusiones: La elevación de la progesterona el día de la captura de ovocitos no empeora el resultado del ciclo de fertilización in vitro en cuanto a tasas de embarazo, aunque se observa una tendencia a la disminución en la tasa de embarazo clínico y mayor cantidad de abortos en el grupo con elevación de la progesterona.

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