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Academia Mexicana de Neurología, A.C.

2019, Número 1

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Rev Mex Neuroci 2019; 20 (1)


Terapias de infusión en la enfermedad de Parkinson avanzada

Navarro-Roa C, Rodríguez-Violante M, Cervantes-Arriaga A

Idioma: Español
Referencias bibliográficas: 59
Paginas: 3-13
Archivo PDF: 174.64 Kb.


RESUMEN

La enfermedad de Parkinson (EP) es un trastorno neurodegenerativo cuyo tratamiento es sintomático, habitualmente iniciado como monoterapia, pero con la progresión de la sintomatología y aparición de complicaciones motores es frecuente el uso de politerapia. El paciente con enfermedad avanzada con respuesta inadecuada al tratamiento con fármacos orales o transdérmicos puede ser candidato a terapias asistidas por dispositivo como la estimulación cerebral profunda, la apomorfina en infusión subcutánea continua (AISC) o la levodopa/carbidopa intestinal en gel (LCIG). Estas dos últimas también reciben la denominación de terapias de infusión. La presente revisión tiene el objetivo de presentar los antecedentes históricos, características farmacológicas, indicaciones, contraindicaciones, inicio y dosificación, efectividad sobre síntomas motores y no motores, perfil de seguridad y selección del candidato ideal de las terapias con AISC y con LCIG para el paciente con EP avanzada.


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