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Revista de la Asociación Médica del Centro Médico ABC

2006, Número 2

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An Med Asoc Med Hosp ABC 2006; 51 (2)


Comparación genómica en micoplasmas de interés médico

Rivera-Tapia JA, Cedillo RL, Giono CS

Idioma: Español
Referencias bibliográficas: 38
Paginas: 74-79
Archivo PDF: 96.29 Kb.


RESUMEN

La familia Mycoplasmataceae, la cual abarca al orden Mycoplasmatales clasificado bajo la clase Mollicutes, contiene a los géneros Mycoplasma y Ureaplasma. Aunque los Mollicutes presentan un genoma notablemente pequeño, pudieron evolucionar a partir de un ancestro común Gram positivo con un contenido de G + C parecido al grupo de Lactobacillus, por la pérdida de una región considerable del genoma. En el humano son seis los Mollicutes (Mycoplasma genitalium, Mycoplasma pneumoniae, Ureaplasma urealyticum, Mycoplasma hominis, Mycoplasma penetrans y Mycoplasma fermentans) que se asocian con enfermedades caracterizadas por alta morbilidad y baja mortalidad, infecciones que pueden ser sistémicas en neonatos y en pacientes inmunocomprometidos. Debido a que los Mollicutes representan un grupo filogenéticamente relacionado con patógenos, por su capacidad para colonizar diferentes huéspedes y sitios anatómicos, son considerados como un grupo de organismo ideal para realizar estudios de comparación genómica. El objetivo de este trabajo es presentar la comparación genómica entre cuatro Mollicutes involucrados con diversos padecimientos en el humano.


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