Ron-Guerrero CS, Ron-Magaña AL, López-Flores JF

Idioma: Español
Referencias bibliográficas: 36
Paginas: 123-132
Archivo PDF: 295.18 Kb.

RESUMEN

Antecedentes: La anemia inflamatoria crónica ocupa el primer lugar de los casos de anemia en pacientes hospitalizados. Por lo general, se asocia con una enfermedad inflamatoria crónica.
Objetivo: Medir la eficacia de la talidomida para incrementar las concentraciones de hemoglobina en pacientes con anemia inflamatoria crónica.
Material y Método: Estudio clínico en el que se incluyeron mujeres adultas con diagnóstico de anemia inflamatoria crónica de la consulta de Hematología del Hospital General Dr. Aquiles Calles Ramírez, Tepic, Nayarit, México, del 1 de febrero de 2015 al 31 de enero de 2017. Las pacientes se asignaron por conveniencia en tres grupos, para administrarles sulfato ferroso (SF), talidomida o sulfato ferroso y talidomida, respectivamente. Se les dio seguimiento durante 90 días después de haber recopilado sus medidas basales de laboratorio. Se compararon medias de hemoglobina y datos hematológicos utilizando las pruebas paramétricas de ANOVA y t de Student o en caso de no cumplir con el supuesto de normalidad se utilizaron las pruebas de Kruskal-Wallis y U de Mann-Whitney.
Resultados: Se incluyeron 18 pacientes. La media de hemoglobina en las pacientes tratadas con talidomida aumentó de 10.5 ± 0.66 a 11.9 ± 1.05 g/dL, con sulfato ferroso aumentó de 10.1 ± 1.25 a 11.5 ± 0.87 g/dL y con talidomida/sulfato ferroso aumentó de 9.5 ± 0.96 a 11.8 ± 1.28 g/dL, con significación de p ‹ 0.001 en cada brazo.
Conclusión: La talidomida es efectiva en la anemia inflamatoria crónica y muestra sinergismo cuando se agrega sulfato ferroso.

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