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2018, Número 4

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Cir Cir 2018; 86 (4)


Efecto de BioOsteo® en combinación con el factor de crecimiento epidérmico y el ácido ascórbico en un defecto de la tibia de la rata

Hernández-Flores C, Domínguez-Hernández VM, Delgado A, Pérez-Moreno R, Valdez-Mijares R

Idioma: Ingles.
Referencias bibliográficas: 34
Paginas: 332-337
Archivo PDF: 237.77 Kb.


RESUMEN

Antecedentes: El tratamiento de los defectos óseos originados por traumatismos o por retiro de materiales de osteosíntesis o de tumores puede ocasionar problemas socioeconómicos derivados del tiempo de tratamiento. Objetivo: Determinar el efecto del material de implante BioOsteo® en combinación con factor de crecimiento epidérmico (EGF) y ácido ascórbico (AA) sobre la consolidación de un defecto óseo de tamaño no crítico. Material y métodos: Se practicó un defecto óseo unicortical no critico en la tibia derecha de ratas Wistar y 3 semanas después se realizó el análisis de las propiedades biomecánicas por medio del ensayo de flexión en tres puntos. Resultados: Encontramos que la aplicación local de una dosis única de AA + EGF + BioOsteo® directamente sobre el microambiente del defecto óseo no crítico favorece su reparación.


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