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2006, Número 2

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Acta Med 2006; 4 (2)


Relación apolipoproteína B/Apolipoproteína AI y componentes del síndrome metabólico en adolescentes con obesidad: Efecto de una dieta hipocalórica baja en carbohidratos

Torres-Colores J, González-Bárcena D, Muñoz-Solís A

Idioma: Español
Referencias bibliográficas: 33
Paginas: 81-88
Archivo PDF: 184.70 Kb.


RESUMEN

Objetivo: Determinar los efectos de una dieta hipocalórica baja en carbohidratos sobre la relación apolipoproteína B/Apolipoproteína A-I y componentes del síndrome metabólico en adolescentes con obesidad. Material y métodos: 10 adolescentes con obesidad, edad promedio 17.9 años. Se determinó la presencia de síndrome metabólico (NCEP-ATP III). Se medió de manera basal y 6 semanas después de una dieta hipocalórica baja en carbohidratos la composición corporal, glucosa, lípidos, ácido úrico, insulina, HOMA, apolipoproteína B, A-I y la relación apoproteína B/apoproteína A-I. Resultados: 7 de los 10 participantes cumplieron criterios de síndrome metabólico. El peso corporal, IMC, perímetro de cintura y porcentaje de grasa corporal disminuyeron significativamente (p 0.0001) al igual que glucemia de ayuno (p 0.02), glucemia 2 horas postcarga (p 0.0001), triglicéridos (p 0.04), HDL-colesterol (p 0.03) insulina (p 0.04) y HOMA (p 0.03). La relación apo B/Apo AI disminuyó 7%. En individuos con reducción de peso › 8 kg la apolipoproteína B disminuyó 8.8% y la relación apo B/Apo AI en 10.9%. En sujetos con reducción del IMC › 3 la apolipoproteína AI aumentó 5.4%, apolipoproteína B disminuyó 11% y la relación Apo B/Apo AI disminuyó 16.8%. Conclusiones: La dieta hipocalórica baja en carbohidratos disminuye en un corto periodo de tiempo la relación Apo-B/Apo-AI, modificando favorablemente los componentes del síndrome metabólico en adolescentes con obesidad.


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