Carrillo-Esper R, Núñez-Monroy FN

Idioma: Español
Referencias bibliográficas: 42
Paginas: 127-134
Archivo PDF: 71.30 Kb.

RESUMEN

El síndrome de respuesta inflamatoria sistémica es desencadenado por diferentes disparadores y tiene como finalidad el limitar y revertir la lesión. La intensidad y evolución de la respuesta inflamatoria es determinada por la magnitud de la lesión disparadora y por el balance existente entre la respuesta inflamatoria y la respuesta antiinflamatoria compensadora. La interacción de los diferentes mediadores solubles de la respuestas inflamatoria y antiinflamatoria determinan las siguientes fases evolutivas: a) respuesta inflamatoria local; b) respuesta inflamatoria sistémica; c) respuesta inflamatoria sistémica masiva; d) parálisis inmunológica; e) disonancia inmune. Las últimas tres de no controlarse, amplifican el daño celular, condicionan y perpetúan el proceso infeccioso y llevan al enfermo a disfunción orgánica múltiple. Se han estudiado, en protocolos clínicos y experimentales, el interferón gama y los esteroides como moduladores de la respuesta inflamatoria, sobre todo en sus fases de parálisis y disonancia inmune con resultados promisorios, pero se requieren estudios a gran escala para validar su utilidad.

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