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ISSN 2007-4360 (Impreso)
Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2018, Número 1-2

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Rev Mex Periodontol 2018; 9 (1-2)


Factor inhibidor de la migración de macrófagos en la enfermedad periodontal

Ortiz-García YM, García-Iglesias T, Hernández-Hernández A, Morales VG, Cervantes-Cabrera JJ, Zamora-Pérez AL

Idioma: Español
Referencias bibliográficas: 32
Paginas: 14-19
Archivo PDF: 333.68 Kb.


RESUMEN

El término enfermedad periodontal abarca una amplia variedad de afecciones inflamatorias crónicas del periodonto, donde se incluye la gingivitis y la periodontitis. La periodontitis es una enfermedad infecciosa que ocurre por la progresión de la gingivitis no tratada. Se caracteriza por un proceso inflamatorio destructivo que afecta a los tejidos de soporte de los dientes, lo que ocasiona la pérdida de éstos. Como resultado de la inflamación, un amplio panel de citocinas y mediadores inflamatorios contribuyen a la degradación del tejido y la reabsorción ósea. Sin embargo, existen moléculas poco estudiadas en el proceso inflamatorio de esta enfermedad; tal es el caso del factor inhibidor de la migración de macrófagos, que es considerada una citocina importante del sistema inmune innato; se expresa constitutivamente en células inmunes y no inmunes; es liberada inmediatamente frente a estímulos bacterianos, señales de hipoxia y proliferativas. El factor inhibidor de la migración de macrófagos se ha descrito en diversas enfermedades crónicas degenerativas, inflamatorias y autoinmunes. Estudios previos han señalado que, en modelos murinos de periodontitis, el factor inhibidor de la migración de macrófagos promueve la activación y diferenciación de osteoclastos, lo que podría posicionar a esta citocina en la inmunopatogenia de la periodontitis en humanos.


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