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2005, Número 3

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Bioquimia 2005; 30 (3)


Participación de la mitocondria en el desarrollo de estrés oxidativo en la obesidad

Martínez-Abundis E, Sánchez-Rodríguez MA, Hafidi-Bentlakder ME

Idioma: Español
Referencias bibliográficas: 52
Paginas: 82-89
Archivo PDF: 87.07 Kb.


RESUMEN

La obesidad es un factor de riesgo para el desarrollo de hipertensión, diabetes, aterosclerosis, entre otras, que se asocian con elevados niveles de marcadores de daño oxidativo, debido posiblemente a alteraciones metabólicas en la mitocondria. Durante la fosforilación oxidativa se forma una pequeña cantidad de especies reactivas de oxígeno (ERO) fisiológicamente, sin embargo, bajo ciertas condiciones patológicas tales como la sobrecarga de O2, falta de adenosin difosfato (ADP), elevados niveles de ácidos grasos libres (AGL), entre otras, la formación de ERO se incrementa en la cadena respiratoria mitocondrial, lo cual induce daño a biomoléculas tales como ADN, lípidos y proteínas. Con esta revisión se pretende presentar la evidencia reciente con relación a los trastornos metabólicos prevalentes en la obesidad, tales como incremento de AGL y sus efectos sobre la mitocondria, su contribución a generar ERO y al incremento de estrés oxidativo.


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