Erazo Valle-Solís AA, Bautista-Santos A, Calderillo-Ruiz G, Campos-Gómez S, Cervantes-Sánchez G, Cortes-Cárdenas S, Chávez-Hernández N, de Anda-González J, Dip-Borunda K, García-Briseño L, Flores-Zorrilla C, González-Huezo S, González-Vela J, Huitzil-Fidel D, Mariscal-Ramírez I, Mora-Pérez J, Orozco-Vázquez J, Pérez-Zincer F, Pimentel-Rentería A, Quintana-Quintana M, Suárez-Sahui T, Torrecillas-Torres L, Padilla-Rosciano A, López-Basave H

Idioma: Español
Referencias bibliográficas: 71
Paginas: 41-50
Archivo PDF: 148.62 Kb.

RESUMEN

Introducción: El hepatocarcinoma (CHC) es un tumor que usualmente presenta un pronóstico desfavorable. En la última década se han presentado avances importantes en su estadificación, diagnóstico y tratamiento, lo que ha modificado la expectativa de vida de estos pacientes. En México existe información limitada sobre los nuevos paradigmas de tratamiento de esta enfermedad. Objetivo: Describir y analizar la evidencia que existe acerca de la epidemiologia, diagnóstico y tratamiento del carcinoma hepatocelular en la población mexicana. Materiales y métodos: Se convocó una reunión de médicos de diferentes especialidades y amplia experiencia en el tratamiento del CHC, quienes proporcionaron información actual en el tratamiento y diagnóstico de dicha patología con el fin de generar una guía para la orientación y el tratamiento de esta enfermedad. Las recomendaciones vertidas en esta revisión fueron conformadas y evaluadas mediante el sistema GRADE (Grading of Recommendations, Assessment, Development and Evaluation). Resultados: Para lograr un impacto en la supervivencia global y en la supervivencia libre de progresión, los pacientes con CHC deben de recibir un tratamiento multidisciplinario, desde la etapa temprana hasta la localmente avanzada. El uso del sorafenib está indicado en pacientes en etapa localmente avanzada Child-Pugh A. Conclusiones: El diagnóstico y el tratamiento del CHC deben individualizarse de acuerdo con lo mostrado en este documento y ser transdisciplinarios; se debe de clasificar al paciente conforme al sistema de la Barcelona Clinic Liver Cancer (BCLC), así como determinar su valoración según la escala del Eastern Cooperative Oncology Group (ECOG) y la Child-Pugh para lograr un impacto en supervivencia global.

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