Domínguez-Ramírez L, Tuena GPM

Idioma: Español
Referencias bibliográficas: 36
Paginas: 18-27
Archivo PDF: 216.57 Kb.

RESUMEN

El pirofosfato pudo haber sido la molécula acarreadora de energía precursora del ATP en la atmósfera primigenia. Durante la evolución, el ATP sustituyó al pirofosfato mostrando una mayor versatilidad funcional. Paralelamente, los sistemas encargados de su síntesis o hidrólisis, H+ pirofosfatasas, ATPasas y la ATP sintasa mitocondrial, fueron mostrando mayor complejidad estructural y diversificado funcionalmente utilizando parte de sus componentes estructurales para realizar funciones diferentes de la síntesis o hidrólisis del ATP. Estos hallazgos han revolucionado el campo de la bioenergética tradicional y abierto nuevos caminos a la investigación de procesos normales y patológicos.

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