2018, Número 1
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Rev Mex Urol 2018; 78 (1)
Análisis de laboratorio para el diagnóstico temprano de insuficiencia renal crónica
López-Heydeck SM, López-Arriaga JA, Montenegro-Morales LP, Cerecero-Aguirre P, Vázquez AGF
Idioma: Español
Referencias bibliográficas: 115
Paginas: 73-90
Archivo PDF: 403.66 Kb.
RESUMEN
La detección temprana de una insuficiencia renal crónica (IRC), permite
prolongar la vida funcional de los riñones, disminuir los casos
de diálisis y el riesgo de muerte por enfermedad cardiovascular. Las
pruebas de diagnóstico de oro son, para daño renal, proteinuria en
orina de 24 horas y para función renal, el filtrado glomerular con
marcadores externos; estas son utilizadas solo a indicios o riesgo de
enfermedad renal, y son imprácticas para estudios epidemiológicos,
por lo que resulta más práctico el utilizar el índice del filtrado glomerular
estimado (IFGe), con una ecuación para marcadores internos,
como es creatinina, cuyo valor se ve influenciado por ingesta de creatina,
producción de creatinina y masa muscular, pero dicho efecto es
aminorado por estas ecuaciones, pero, al haber también variaciones
según el método de laboratorio y entre laboratorios, las más recientes
ecuaciones requieren valores de creatinina estandarizados al método
de referencia internacional espectrometría de masas por dilución isotópica,
el cual solo se ha establecido en algunos países y en menos
países todo valor de creatinina se da junto con el valor del IFGe y
pocos países aplican el índice de la relación proteína-creatinina en
una sola toma de muestra de orina”, del inglés “spot urine proteincreatinine
ratio”
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