2017, Número 5
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Gac Med Mex 2017; 153 (5)
Cáncer del tracto digestivo: asociación entre el estado nutricional y la capacidad funcional
Pérez-Cruz E, Camacho-Limas CP
Idioma: Español
Referencias bibliográficas: 34
Paginas: 575-580
Archivo PDF: 196.08 Kb.
RESUMEN
Objetivo: Determinar el estado nutricional y su asociación con la capacidad funcional en pacientes con cáncer del tracto digestivo.
Métodos: Estudio retrospectivo observacional y analítico, realizado en pacientes adultos hospitalizados con diagnóstico
inicial de cáncer del tracto digestivo. Las variables estudiadas fueron el estado nutricional y la capacidad funcional. Se utilizó
estadística descriptiva y asociación con razón de momios (odds ratio [OR]) en paquete estadístico SPSS 14.0.
Resultados: Se
incluyeron 57 pacientes, de los cuales el 96% presentaron pérdida de peso. Usando la evaluación global subjetiva (EGS)
como método de tamizaje se determinó que el 82.5% de la población estaba desnutrida, y mediante pruebas bioquímicas e
inmunológicas lo estaban el 82% y el 65%, respectivamente. La capacidad funcional se evaluó mediante el índice de Karnofsky,
encontrando que el 75.5% de la población tiene alguna limitación en la actividad. Los resultados muestran una asociación
entre desnutrición por EGS y limitación en la capacidad funcional (χ
2 = 1.56; p = 0.212; OR: 2.46; intervalo de confianza del
95% [IC 95%]: 0.581-10.465). Además, se observó una asociación entre el recuento total de linfocitos y la capacidad funcional
(χ
2 = 6.94; p = 0.008; OR: 5.23; IC 95%: 1.441-19.025).
Conclusiones: La desnutrición en pacientes con cáncer de
tracto digestivo se asocia con limitación en la capacidad funcional.
REFERENCIAS (EN ESTE ARTÍCULO)
American Cancer Society. Cancer facts and figures 2011. Atlanta: American Cancer Society; 2011. p. 1-55.
McMahon K, Decker G, Ottery FD. Integrating proactive nutritional assessment in clinical practices to prevent complications and cost. Semin Oncol. 1998;25(2 Suppl 6) 20-7.
Abdo Francis JM. Cáncer del aparato digestivo. Revista Médica Hospital General de México. 2010;73:7.
Bruera E. ABC of palliative care. Anorexia, cachexia, and nutrition. BMJ. 1997;315:1219-22.
Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs. 2005;9(Suppl 2):S51-63.
McMillan DC. An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer. Proc Nutr Soc. 2008;67:257-62.
Eldridge B, Rock CL, McCallum PD. Nutrition and the Patient with Cancer. In: Nutrition in the Prevention and Treatment of Disease. Ed. Coulston AM, Rock CL, Monsen ER. Academic Press, San Diego, 2001. pg. 397-412.
Ek AC, Unosson M, Larsson J, et al. Interrater variability and validity in subjective nutritional assessment of elderly patients. Scand J Caring Sci. 1996;10:163-8.
Enia G, Sicuso C, Alati G, et al. Subjective Global Assessment of nutrition in dialysis patients. Nephrol Dial Transplant.1993;8:1094-8.
Karnofsky DA, Abelman WH, Craver LF, et al. The use of nitrogen mustards in the palliative treatment of cancer. Cancer. 1948;1 634-56.
Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer. En: MacLeod CM, editor. Evaluation of chemotherapeutic agents. New York: Columbia University Press; 1949. p. 191-205.
Puiggròs C, Lecha M, Rodríguez T, et al. Karnofsky Index as a mortality predicting factor in patients on home-based enteral nutrition. Nutr Hosp. 2009;24:156-60.
Ruiz-Delgado GJ, Lutz-Presno JA, Alarcón-Urdaneta C, et al. Body mass index as an indicator of prognosis in patients undergoing allogenic hematopoietic stem cell transplantation. Rev Hematol Mex. 2011;12:28-31.
Detsky AS, McLaughlin JR, Baker JP, et al. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr. 1987;11:8-13.
Rivadeneira DE, Evoy D, Fahey TJ 3rd, et al. Nutritional support of the cancer patient. CA Cancer J Clin. 1998;48:69-80.
Moon H, Roh JL, Lee SW, et al. Prognostic value of nutritional and hematologic markers in head and neck squamous cell carcinoma treated by chemoradiotherapy. Radiother Oncol. 2016;118 330-4.
Cho YW, Roh JL, Jung JH, et al. Prediction of prosttreatment significant body weight loss and its correlation with disease free survival in patients with oral squamous cell carcinomas. Nutr Cancer. 2013;65:417-23.
Tolentino R, Quizon O, Llido L. Nutritional status of patients with malignancy of the gastrointestinal tract and other malignancies − comparison of characteristics and pattern: a two-year study in a private tertiary care hospital in the Philippines. Philip J Oncology. 2007;8:37-44.
Huang SH, Waldron JN, Milosevic M, et al. Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status. Cancer. 2015;121 545-55.
De Carvalho TM, Miguel Marin D, da Silva CA, et al. Evaluation of patients with head and neck cancer performing standard treatment in relation to body composition, resting metabolic rate, and inflammatory cytokines. Head Neck. 2015;37:97-102.
Rassouli A, Saliba J, Castano R, et al. Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma. Head Neck. 2015;37:103-10.
Cannon NA, Meyes J, Iyengar P, et al. Neutrophil-lymphocyte and platelet- lymphocyte ratios as prognostic factors after stereotactic radiation therapy for early-stage non-small-cell lung cancer. J Thorac Oncol. 2015;10:280-5.
Fan W, Zhang Y, Wang Y, et al. Neutrophil-to-lymphocyte and platelet- to-lymphocyte ratios as predictors of survival and metastasis for recurrent hepatocellular carcinoma after transarterial chemoembolization. PLos One. 2015;10:e0119312.
Kim EY, Lee JW, Yoo HMY. The platelet-to-lymphocyte ratio versus neutrophil-to-lymphocyte ratio: which is better as a prognostic factor in gastric cancer? Ann Surg Oncol. 2015;22:4363-70.
Mor V, Laliberte L, Morris JN, et al. The Karnofsky Performance Status Scale: an examination of its reliability and validity in a research setting. Cancer. 1984;53:2002-7.
Loperinzi CL, Laurie JA, Wieand HS, et al. Prospective evaluation of prognostic variables from patient-completed questionnaires. J Clin Oncol. 1994;12:601-7.
Buccheri G, Ferrigno D, Tamburini M. Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. Eur J Cancer. 1996;32A:1531-41.
Yates JW, Chalmer B, McKegney FP. Evaluation of patients with advanced cancer using the Karnofsky Performance Status. Cancer. 1980; 45:2220-4.
Maltoni M, Pirovano M, Scarpi E, et al. Prediction of survival of patients terminally ill with cancer. Results of an Italian prospective multicentric study. Cancer. 1995;75 2613-22.
Ottery FD. Supportive nutrition to prevent cachexia and improve quality of life. Semin Oncol. 1995;22(Suppl 3):98-111.
Maltoni M, Nanni O, Derni S, et al. Clinical prediction of survival is more accurate than the Karnofsky performance status in estimating life span of the terminally ill cancer patients. Eur J Cancer. 1994;30:764-6.
McMillan DC. An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer. Proc Nutr Soc. 2008;67:257-62.
Gârtner S, Krûger J, Aghdassi AA, et al. Nutrition in pancreatic cancer: a review. Gastrointest Tumors. 2015;2:195-202.
Rosania R, Chiapponi C, Malfertheiner P, et al. Nutrition in patients with gastric cancer: an update. Gastrointest Tumors. 2015;2:178-87.