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2017, Número 5

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Gac Med Mex 2017; 153 (5)


Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

López-Bautista F, Posadas-Romero C, Cardoso-Saldaña G, Juárez-Rojas JG, Medina-Urrutia A, Pérez-Hernández N, Rodríguez-Pérez JM, Vargas-Alarcón G, Posadas-Sánchez R

Idioma: Español
Referencias bibliográficas: 45
Paginas: 566-574
Archivo PDF: 285.59 Kb.


RESUMEN

Objetivo: Investigar la asociación independiente de la deficiencia de vitamina D (DVD) con la enfermedad arterial coronaria (EAC) en población adulta. Método: Estudio de casos y controles pareado. Se obtuvieron datos de factores de riesgo cardiovascular, medicamentos, alcohol, tabaquismo, consumo de vitamina D y actividad física. Se midieron variables bioquímicas, antropométricas y de presión arterial. La 25(OH)D se cuantificó por quimioluminiscencia. Resultados: Se estudiaron 250 pacientes con EAC establecida y 250 sujetos control, pareados por edad, sexo e índice de masa corporal (IMC), de 53 ± 6.1 años e IMC de 28 ± 3.5 kg/m2. La DVD fue significativamente mayor en el grupo control (21.2 vs. 16%). El análisis de regresión logística múltiple no mostró asociación entre la DVD y la EAC (OR: 1.37 [0.08-23.2]). El análisis de regresión lineal múltiple mostró que el uso de estatinas (b = 2.2; p = 0.004) y el no consumo de alcohol (b = −1.8; p = 0.03) incrementaron significativamente la concentración de 25(OH)D. Conclusiones: En adultos mexicanos no se encontró asociación independiente entre la DVD y la presencia de EAC. Los resultados sugieren que el tratamiento con estatinas y la abstinencia en el consumo de alcohol pueden ser la explicación para las concentraciones más altas de 25(OH)D encontradas en los pacientes con EAC.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. WHO. Global health estimates 2014 summary tables: deaths by cause, age and sex, 2000-2012. (Consultado el 4 de marzo de 2015.) Disponible en: http://www.who int/healthinfo/global_burden_disease/estimates/ en/index1.html

  2. INEGI. Estadísticas de mortalidad 2011. (Consultado el 4 de marzo de 2015.) Disponible en: http://www.inegi.org mx/sistemas/sisept/Default. aspx?t=mdemo107&s=est&c=23587

  3. WHO. Global health estimates summary tables: projection of deaths by cause, age and sex. (Consultado el 4 de marzo de 2015.) Disponible en: http://www.who.int/healthinfo/global_burden_disease/projections/en

  4. Hilger J, Friedel A, Herr R, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014;111:23-45.

  5. Scragg R. Seasonality of cardiovascular disease mortality and the possible protective effect of ultra-violet radiation. Int J Epidemiol. 1981;10:337-41.

  6. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27:2813-8.

  7. Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-hydroxy vitamin D levels and risk of incident hypertension. Hypertension. 2007;49:1063-9.

  8. Ford ES, Ajani UA, McGuire LC, et al. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care. 2005;28:1228-30.

  9. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159-65.

  10. Shor R, Tirosh A, Shemesh L, et al. 25 hydroxyvitamin D levels in patients undergoing coronary artery catheterization. Eur J Intern Med. 2012;23:470-3.

  11. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353-73.

  12. Tomson J, Emberson J, Hill M, et al. Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12,000 deaths. Eur Heart J. 2013;34:1365-74.

  13. Deleskog A, Piksasova O, Silveira A, et al. Serum 25-hydroxyvitamin D concentration, established and emerging cardiovascular risk factors and risk of myocardial infarction before the age of 60 years. Atherosclerosis. 2012;223:223-9.

  14. De Boer IH, Kestenbaum B, Shoben AB, et al. 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification. J Am Soc Nephrol. 2009;20:1805-12.

  15. Flores M, Sánchez-Romero LM, Macias N, et al. Concentraciones séricas de vitamina D en niños, adolescentes y adultos mexicanos. Resultados de la ENSANUT 2006. Cuernavaca, México: Instituto Nacional de Salud Pública; 2011.

  16. Posadas-Romero C, Jorge-Galarza E, Posadas-Sánchez R, et al. Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis. Eur J Endocrinol. 2014;171 319-25.

  17. Hernández-Ávila M, Romieu I, Parra S, et al. Validity and reproducibility of a food frequency questionnaire to assess dietary intake of women living in Mexico City. Salud Publica Mex. 1998;40:133-40.

  18. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982;36:936-42.

  19. Freeman D. Applied categorical data analysis. 1987.

  20. DeLong DM, DeLong ER, Wood PD, et al. A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study. JAMA. 1986;256 2372-7.

  21. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487-95.

  22. American Diabetes Association. Standards of medical care in Diabetes - 2009. Diabetes Care. 2009;32:s13-63.

  23. Abbott. Architect, 25-OH-Vitamin D. Una forma brillante de detectar la vitamina D.

  24. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53-8.

  25. Hérnandez-Ávila M, Resoles M, Parra S, et al. Sistema de evaluacion de hábitos nutricionales y consumo de nutrimentos (SNUT).

  26. Marques MD, Santos RD, Parga JR, et al. Relation between visceral fat and coronary artery disease evaluated by multidetector computed tomography. Atherosclerosis. 2010;209:481-6.

  27. Mautner GC, Mautner SL, Feuerstein IM, et al. Coronary artery calcification: assessment with electron beam CT and histomorphometric correlation. Radiology. 1994;192:619-23.

  28. Pilz S, Verheren N, Grübler MR, et al. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2016;13:404-17.

  29. Pérez-Hernández N, Aptilon-Duque G, Nostroza-Hernández MC, et al. Vitamin D and its effects on cardiovascular diseases: a comprehensive review. Korean J Intern Med. 2016;31:1018-29.

  30. Kassi E, Adamopoulos C, Basdra EK, et al. Role of vitamin D in atherosclerosis. Circulation. 2013;128:2517-31.

  31. Cigolini M, Pina-Iagulli M, Miconi V, et al. Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Diabetes Care. 2006;29:722-4.

  32. Rajasree S, Rajpal K, Kartha C, et al. Serum 25-hydroxyvitamin D3 levels are elevated in South Indian patients with ischemic heart disease. Eur J Epidemiol. 2001;17:567-71.

  33. Hosseinpanah F, Yarjanli M, Sheikholeslami F, et al. Associations between vitamin D and cardiovascular outcomes; Tehran Lipid and Glucose Study. Atherosclerosis. 2011;218:238-42.

  34. Lai S, Fishman E, Gerstenblith G, et al. Vitamin D deficiency is associated with coronary artery calcification in cardiovascularly asymptomatic African Americans with HIV infection. Vasc Health Risk Manag. 2013;9:493-500.

  35. Lai H, Fishman EK, Gerstenblith G, et al. Vitamin D deficiency is associated with development of subclinical coronary artery disease in HIV-infected African American cocaine users with low Framingham-defined cardiovascular risk. Vasc Health Risk Manag. 2013;9: 729-37.

  36. Targher G, Bertolini L, Padovani R, et al. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol (Oxf). 2006;65:593-7.

  37. Young KA, Snell-Bergeon JK, Naik RG, et al. Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. Diabetes Care. 2011;34:454-8.

  38. Lim S, Shin H, Kim MJ, et al. Vitamin D inadequacy is associated with significant coronary artery stenosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging. J Clin Endocrinol Metab. 2012;97:169-78.

  39. Autier P, Boniol M, Pizot C, et al. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76-89.

  40. Theodoratou E, Tzoulaki I, Zgaga L, et al. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta- analyses of observational studies and randomised trials. BMJ. 2014;348:g2035.

  41. Miettinen ME, Kinnunen L, Leiviskä J, et al. Association of serum 25-hydroxyvitamin D with lifestyle factors and metabolic and cardiovascular disease markers: population-based cross-sectional study (FIN-D2D). PLoS One. 2014;9:e100235.

  42. Legeai C, Vigouroux C, Souberbielle J, et al. Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» Cohort Study. PLoS One. 2013;8:e74868.

  43. Aloia JF, Li-Ng M, Pollack S. Statins and vitamin D. Am J Cardiol. 2007;100:1329.

  44. Pérez-Castrillón JL, Vega G, Abad L, et al. Effects of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Am J Cardiol. 2007;99:903-5.

  45. Pearce SHS, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ. 2010;340:142-7.




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