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ISSN 0187-5337 (Impreso)
Instituto Nacional de Perinatología

2005, Número 3-4

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Perinatol Reprod Hum 2005; 19 (3-4)


Neurodesarrollo en infantes con antecedente de hipotiroidismo congénito

Arreola-Ramírez G, Barrera- Reyes RH, Jiménez-Quiroz R, Ramírez TMA, Segura-Cervantes E, Granados-Cepeda ML, Ramírez-Vargas MN, Meza-Rodríguez MP

Idioma: Español
Referencias bibliográficas: 65
Paginas: 141-151
Archivo PDF: 129.11 Kb.


RESUMEN

Introducción: Los estudios de seguimiento de infantes con hipotiroidismo congénito con tratamiento temprano, muestran que no existen diferencias con respecto al coeficiente intelectual que se encuentra en la población general.
Material y métodos: Estudio de cohorte retrospectivo. Veinticuatro hipotiroideos fueron detectados a través del Programa de Tamiz Neonatal y comparados con un grupo testigo. Los recién nacidos fueron valorados entre los seis meses y los siete años de edad mediante el índice de desarrollo (ID) de Bayley, el coeficiente intelectuales (CI) de Terman Merril y la prueba Hiskey Nebraska para detectar infantes con hipoacusia.
Resultados: Dieciocho infantes hipotiroideos mostraron CI o ID normal o alto. Uno con ID de Bayley por abajo del promedio, dos con CI por abajo del promedio y uno con hipoacusia y capacidad de aprendizaje baja. No se encontraron diferencias con respecto al grupo control. El uso de ototóxicos, prematurez e hiperbilirrubinemia, fueron las causas que explicaron los coeficientes bajos entre los hipotiroideos y el grupo control.
Conclusiones: El CI y el ID en el grupo de hipotiroidismo tratado tempranamente no difirió con los resultados del grupo testigo.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Velázquez A, Loera LA, Aguirre BE, Gamboa S, Vargas H, Robles C. Tamiz neonatal para hipotiroidismo congénito y fenilcetonuria. Salud Publica Mex 1994; 36: 249-56.

  2. Vela M, Aguirre BE, Gamboa S, Delgado A. El tamiz neonatal en México: experiencia de un millón de tamizados para HC. En: AMP: Congreso Nacional de Pediatría; 1998 Jun 23-27, México: CONAPEME;; 1998, p. 14.

  3. Loera LA, Aguirre BE, Gamboa S, Vargas H, Robles C, Velásquez A. Resultados del Programa para la Prevención del Retraso Mental producido por Hipotiroidismo Congénito. Bol Med Hosp Infant Mex 1996; 53: 259-62.

  4. Velázquez A. El nuevo tamiz neonatal: una revolución en la pediatría preventiva. Bol Med Hosp Infant Mex 1998; 55: 311-12.

  5. Secretaría de Salud. Norma Oficial Mexicana NOM-007 SSA2-1993. Para la atención de la mujer durante el embarazo, parto y puerperio a recién nacidos. Criterios y procedimientos para la prestación del servicio. México: SSA, 1995.

  6. Casanueva E, Abarca R, Jiménez A, Lorenzana S, Palomino C, Sánchez B, et al. Programa de Prevención del Retardo Mental por Tamiz Neonatal. Estrategias para Optimizar la Cobertura. Perinatol Reprod Hum 1988; 2: 149-54.

  7. Granados CML. Comité del Tamiz Neonatal en el Instituto Nacional de Perinatología (COTAN-INPer) México, D. F. Departamento de Análisis y Estadística.

  8. La Franchi S. Congenital hypothyroidism: etio-logies, diagnosis and management. Thyroid 1999; 9: 735-40.

  9. Rovet J. Congenital hypothyroidism: long term outcome. Thyroid 1999; 9: 741-8.

  10. Klein AH, Meltzer S, Kenny FM. Improved prognosis in congenital hypotiroidism treated before age three months. J Pediatr 1972; 81: 912-15.

  11. New England Congenital Hypothyroidism Collaborative. Characteristics of infantile Hypothyroidism discovered on neonatal scree-ning. J Pediatr 1984; 104: 539-44.

  12. New England Congenital Hypothyroidism Collaborative. Effects of neonatal screening for hypothyroidism: prevention of mental retardation by treatment before clinical manifestations. Lancet 1981; 2: 1095-8.

  13. New England Congenital Hypothyroidism Collaborative. Elementary school performance of children with congenital hypothyroidism. J Pediatr 1990; 116: 27-32.

  14. Kooistra L, Laane C, Vulsma T, Schellekens JMH, van der Meere JJ, Kalverboer AF. Motor and cognitive development in children with congenital hypothyrodism: a long-term evaluation of the effects of neonatal treatment. J Pediatr 1994; 124; 903-9.

  15. Salerno M, Di Maio S, Militerni R, Argenziano A, Valerio G, Tenore A. Prognostic factors in the intellectual development at 7 years of age in children with congenital hypothyroidism. J Endocrinol Invest 1995; 18: 774-9.

  16. Simons WF, Fuggle PW, Grant DB, Smith I. Intellectual development at 10 years in early treated congenital hypothyroidism. Arch Dis Child 1994; 71: 232-4.

  17. Alvarez M, Berazain A, Alonso E, Hernández M, Robaina R, Guell R, et al. Estado neurocognitivo en niños con hipotiroidismo congénito tratados precozmente. Seguimiento a diez años. 2º. Congreso Latinoamericano de tamiz neonatal 1999, Santiago de Chile 24-27 de octubre.

  18. Rovet JF, Ehrlich RM. Long term effects of L-thyroxine therapy for congenital hypothyroi-dism. J Pediatr 1995; 126: 380-6.

  19. Rovet JF. Long term neuropsychological sequelae of early-treated congenital hypothyroidism: effects in adolescence Acta Paediatr Suppl 1999; 88(Suppl 4)32: 88-95.

  20. Rovet JF, Ehrlich RM. Psychoeducational outcome in children with early-treated congenital hypothyroidism. Pediatrics 2000; 105: 515-22.

  21. Bargagna S, Dinetti D, Pinchera A, Marcheschi M, Montanelli L, Presciuttini S. School attainments in children with congenital hypothyroidism detected by neonatal screening and treated early in life. Eur J Endocrinol 1999; 140: 407-13.

  22. Van Vliet G, Merck AG. Thyroid Symposium treatment and outcome. Thyroid 1999; 9: 79-84.

  23. Ilicki A, Larsson A, Mortensson W. Neonatal skeletal maturation in congenital hypothyroidism and its prognosis value for psychomotor development at 3 years in patients treated early. Horm Res 1990; 33; 260-4.

  24. Tillotson S, Fuggle PW, Smith I, Ades AE, Grant DB. Relation between biochemical severity and intelligence in early treated congenital hypothyroidism: a threshold effect. BMJ 1994; 309: 440-5.

  25. Naruse H. Developmental of neonatal screening in Japan. Tokio: Tokio Institute of Medical Science, Kyorin University; 1995 Feb.

  26. Illig R, Torresani T. TSH determination in dried blood: a reliable, efficient, and inexpensive method for neonatal thyroid screening. In: Burrow GN, Dussault JH, editors. Neonatal thyroid screening. New Cork: Raaven Press; 1980, pp. 87-94.

  27. National Committee for Clinical Laboratory Standards. Blood collection on filter paper for neonatal screening programs: approved standard. Villanova, PA: National Committee for clinical Laboratory Standards 1992. NCCLS Publication LA4-A2.

  28. Bayley N (1993). Bayley Scales Development. 2nd ed. USA The Psychological Corporation.

  29. Thorndike R, Hagen E, Saltter J. Guide for administering and scoring, Standford-Binet Intelligence Scale. 4th ed. USA: The Riverside Publishing Company; 1986.

  30. Hiskey Nebraska, Prueba de aptitudes para el aprendizaje; Manual del Instituto Nacional de la Comunicación Humana, adaptación de la prueba en niños oyentes y sordos entre 3 y 16 años. México; 1995.

  31. Vela M, Gamboa S, Loera-Luna A, Aguirre BE, Pérez PG, Velázquez A. Neonatal scree-ning for congenital hypothyroidism in Mexico: experience, obstacles, and strategies. J Med Screen 1999; 6: 77-9.

  32. Hunter I, Greene SA, MacDonald TM, Morris A. Prevalence and aetiology of hypothyroidism in the young. Arch Dis Child 2000; 83: 207-10.

  33. Vega HE, Chávez TR. El tamiz metabólico neonatal en neonatos enfermos de un hospital de concentración. Rev Mex Pediatr 1998; 65: 200-6.

  34. Song S, Daneman D, Rovet J. The influence of etiology and treatment factors on intellectual outcome in congenital hypothyroidism. J Behav Pediatr 2001; 22: 376-84.

  35. Oerbeck B, Sundet K, Kase BF, Heyerdahl S. Congenital hypothyroidism: influence of di-sease severity and L-thyroxine treatment on intellectual, motor, and school associated outcomes in young adults. Pediatrics 2003; 112: 923-30.

  36. Léger J, Larroque B, Norton J. Influence of severity of congenital hypothyroidism and adequacy of treatment on school achievement in young adolescents: a population based cohort study. Acta Paediatr 2001; 90: 1249-56.

  37. Glorieux J, Dussault J, Van Vliet G. Intellectual development at age 12 years of children with congenital hypothyroidism diagnosed by neonatal screening. J Pediatr 1992; 121: 581-4.

  38. Ilicki A, Larsson A. Psychological development at 7 years in children with congenital hypothyroidism. Acta Paediatr Scand 1991; 80: 199-204.

  39. Heyerdahl S, Kase BF, Lie SO. Intellectual development in children with congenital hypothyroidism in relation to recommended thyroxine treatment. J Pediatr 1991; 118: 850-7.

  40. Rovet JF, Ehrlich RM, Sorbara DL. Effect of thyroid hormone level on temperament in infants with congenital hypothyroidism detected by screening of neonates. J Pediatr 1989; 114: 63-8.

  41. Derksen-Lubsen G, Verkerk PH. Neuropsy-chologic development in early treated congenital hypothyrodism: analysis of literature data. Pediatr Res 1996; 39: 561-6.

  42. Campos SP, Sandberg DE, Barric C, Voorhees ML, MacGillivray MH. Outcome of lower L-thyroxine treatment of congenital hypothyroidism. Clin Paediatr 1995; 34: 514-20.

  43. Kamianou F, Makaronis G, Lambadaris J, Sarafidou E, Vrachni F, Mengreli C, Pantelakis S. Psychomotor development in congenital hypothyroidism. The Greek screening programme. Eur J Pediatr 1988; 147: 275-8.

  44. Bongers-Schokking JJ. Pre and postnatal development in neonates with Congenital Hypothyroidism. J Pediatr Endocrinol Metab 2001; 14(Suppl 6): 1463-8.

  45. Bongers-Schokking JJ, Koot HM, Wiersma D, Verkerk PH, de Muinck Keizer-Scharama SMPF. Influence of timing and dose of thyroid hormone replacement on development in infants with congenital hypothyroidism. J Pediatr 2000; 136: 292-7.

  46. Hopwood NJ. Treatment of the infant with congenital hypothyroidism. J Pediatr 2002; 141: 752-3.

  47. Dubuis JM, Glorieux J, Richer F, Deal CL, Dussault JH, Van Vliet G. Outcome of severe congenital Hipothyroidism: closing the deve-lopmental gap with early high dose levothyroxi1ne treatment. J Clin Endocrinol Metabo 1996; 81: 222-7.

  48. Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, et al. Neurodevelop-mental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Develoment Neonatal Research Network, 1993-1994. Pediatrics 2000; 105: 1216-26.

  49. Hack M, Wilson-Costello D, Friedman H, Taylor G, Schuchter M, Fanaroff A. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000g. Arch Pediatr Adolesc Med 2000; 154: 725-31.

  50. McGrath M, Sullivan M, Lester BM, Oh W. Longitudinal neurologic follow-up in neonatal intensive care unit survivors with various neonatal morbidities. Pediatrics 2000; 106: 1397-1405.

  51. Koller H, Lawson K, Rose S, Wallace I, McCarton C. Patterns of cognitive development in very low birth weight children during the first six years of life. Pediatrics 1997; 99: 382-9.

  52. Van Wassenaer AG, Kok J. Hypothyroxinaemia and thyroid function after preterm birth. Seminars in Neonatology 2004; 9: 3-11.

  53. Ogilvy-Stuart AL. Neonatal thyroid disorders. Arch Dis Child Fetal Neonatal Ed 2002; 87: F165-F171.

  54. Lucas A, Morley R, Fewtrell M. Low triiodo-thyronine concentration in preterm infants and subsequent intelligence quotient (IQ) at 8 year follow up. BMJ 1996; 312: 1132-3.

  55. Osborn DA. Thyroid hormones for preventing neurodevelopmental impairment in preterm infants. The Cochrane Database of Systematic Reviews 2003; 3.

  56. Den Ouden AL, Kok JH, Verkerk PH, Brand R, Verloove-Vanhorick. The relation between Neonatal Thyroxine Levels and Neurodeve-lopmental outcome al age 5 and 9 years in a National Cohort of very preterm and/or very low birth weight infants. Pediatr Res 1996; 39: 142-5.

  57. Rapaport R. Thyroid function in the very low birth weight newborn: Rescreen or reevalua-te? J Pediatr 2002; 140: 287-9.

  58. Larson C, Hermos R, Delaney A, Daley D, Mitchell M. Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism. J Pediatr 2003; 143: 587-91.

  59. Watchko JF, Maisels MJ. Jaundice in low birthweight infants: pathobiology and outcome. Arch Dis Child Fetal Neonatal Ed 2003: 88: F455-F458.

  60. Shapiro SM. Bilirrubin Toxity in the developing Nervous System. Pediatr Neurol 2003; 29: 410-21.

  61. van de Bor M, van Zeben-van der Aa TM, Verloove-Vanhorick P, Brand R, Ruys J. Hyperbilirrubinemia in very preterm infants and neurodevelopment outcome at two years of age: results of a national collaborative survey. Pediatrics 1989; 83: 915-20.

  62. Scheidt PC, Bryla DA, Nelson KB, Hirtz DG, Hoffman HJ. Phototherapy for neonatal hiperbilirrubinemia. Six year follow-up of the NICHHD clinical trial. Pediatrics 1990; 85: 455-63.

  63. 63, Scheidt PC, Graubard BI, Nelson KB, Hirtz DG, Hoffman HJ, Gartner LM, et al. Intelligence al six years in relation to neonatal bilirrubin level: follow-up of the National Ins-titute of Child Health and Human Development Clinical Trial of Phototherapy. Pedia-trics 1991; 87: 797-805.

  64. Vries LS, Lary S, Dudowitz LMS. Relationship of serum levels to otoxicity and deafness in High-Risk low birth weight infants. Pedia-trics 1985; 76: 351-4.

  65. Martínez CC, Fernández CL, Ortigosa CE, Perfil audiométrico del niño hipoacúsico egresado de una Unidad de Cuidado Intensivo Neonatal: análisis de 40 casos. Bol Med Hosp Infant Méx 2000; 57: 140-4.




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