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2016, Número 3

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Gac Med Mex 2016; 152 (3)


Utilidad de los microARN en el diagnóstico y pronóstico del cáncer colorrectal (CCR)

Arredondo-Valdez AR, Wence-Chavez L, Rosales-Reynoso MA

Idioma: Español
Referencias bibliográficas: 128
Paginas: 386-396
Archivo PDF: 206.15 Kb.


RESUMEN

El objetivo de esta revisión es presentar un panorama general sobre la importancia de los microARN en el CCR. Primero nos enfocaremos en los mecanismos por los cuales los microARN regulan la expresión de sus genes diana y cómo una regulación alterada de los microARN está asociada con diversos tipos de cáncer, incluyendo el CCR. Posteriormente, se abordarán algunos ejemplos de microARN que han sido asociados con cáncer y cómo los patrones de expresión de ciertos microARN pueden ser utilizados como biomarcadores potenciales para el diagnóstico, pronóstico y la respuesta terapéutica en el CCR. Finalmente se describen cómo algunos polimorfismos presentes en los microARN se asocian con el riesgo y pronóstico en el CCR.


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