medigraphic.com

2016, Número 3

<< Anterior Siguiente >>

Rev Med MD 2016; 7.8 (3)


Enfermedad relacionada a IgG4: una entidad multifacética

Martín-Nares E, Álvarez-López F, Solis-Vargas E, Araujo-Ramírez O, Coss y León-Rubio L, Vargas-Sánchez ÁJ, Rull-Gabayet M

Idioma: Español
Referencias bibliográficas: 96
Paginas: 155-169
Archivo PDF: 1208.34 Kb.


RESUMEN

La enfermedad relacionada a IgG4 (ER-IgG4) es una enfermedad autoinmune multisistémica caracterizada por lesiones fibroesclerosantes formadoras de masas o pseudotumores, concentraciones elevadas de IgG4 séricas e infiltración tisular extensa por células plasmáticas IgG4+. La ER-IgG4 incluye numerosas entidades que previamente se consideraban órgano-específicas como la pancreatitis autoinmune y la enfermedad de Mikulicz. La ER-IgG4 puede afectar prácticamente a cualquier órgano, siendo los más afectados páncreas, glándulas salivales, glándulas lacrimales, ganglios linfáticos, retroperitoneo y riñones. El diagnóstico se realiza mediante una combinación de hallazgos clínicos, serológicos, imagenológicos e histopatológicos. La ER-IgG4 usualmente responde al tratamiento con corticoesteroides, sin embargo las recaídas son frecuentes. La ER-IgG4 es una entidad infradiagnosticada debido en parte a que fue caracterizada recientemente y no es conocida ampliamente en la comunidad médica. Esta revisión tiene como objetivo ampliar el conocimiento de esta enfermedad, ya que puede ser encontrada inicialmente por cualquier rama de le medicina.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Hamano H, Kawa S, Horiuchi a, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344(10):732–8.

  2. Kamisawa T, Egawa N, Nakajima H. Autoimmune pancreatitis is a systemic autoimmune disease. Am J Gastroenterol. 2003;98(12):2811–2.

  3. Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38(10):982–4.

  4. Takahashi H, Yamamoto M, Suzuki C, Naishiro Y, Shinomura Y, Imai K. The birthday of a new syndrome: IgG4-related diseases constitute a clinical entity. Autoimmunity Reviews. 2010. p. 591–4.

  5. Islam AD, Selmi C, Datta-Mitra A, Sonu R, Chen M, Gershwin ME, et al. The changing faces of IgG4- related disease: Clinical manifestations and pathogenesis. Autoimmunity Reviews. Elsevier B.V.; 2015. p. 914–22.

  6. Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet. Elsevier Ltd; 2014;6736(14):1–12.

  7. Inoue D, Yoshida K, Yoneda N, Ozaki K. IgG4- Related Disease: Dataset of 235 Consecutive Patients. 2015;94(1354):1–8.

  8. Uchida K, Masamune A, Shimosegawa T, Okazaki K. Prevalence of IgG4-related disease in Japan based on nationwide survey in 2009. Int J Rheumatol. 2012;2012.

  9. Mannion M, Cron RQ. Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: case report and a review of the pediatric autoimmune pancreatitis literature. Pediatr Rheumatol Online J. 2011;9(1):1.

  10. Gillispie MC, Thomas RD, Hennon TR. Successful treatment of IgG-4 related sclerosing disease with rituximab: A novel case report. Clin Exp Rheumatol. 2015;33(4):549–50.

  11. Wallace ZS, Deshpande V, Mattoo H, Mahajan VS, Kulikova M, Pillai S, et al. IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients. Arthritis Rheumatol (Hoboken, NJ). 2015;67(9):2466–75.

  12. Zen Y, Nakanuma Y. IgG4-related disease: a crosssectional study of 114 cases. Am J Surg Pathol. 2010;34(12):1812–9.

  13. Campochiaro C, Ramirez GA, Bozzolo EP, Lanzillotta M, Berti A, Baldissera E, et al. IgG4- related disease in Italy: clinical features and outcomes of a large cohort of patients. Scand J Rheumatol. 2015;1–11.

  14. Ebbo M, Daniel L, Pavic M, Se P, Berthelot J, Papo T, et al. IgG4-Related Systemic Disease Features and Treatment Response in a French Cohort: Results of a Multicenter Registry. 2012;91(1):49–56.

  15. Bourlon T, Bourlon C, Atisha-fregoso Y, Chablemontero F, Teliz MA, Angeles-angeles A, et al. Clinical and Immunopathologic Profile of Mexican Patients with IgG4 Autoimmune Pancreatitis. 2012;2012:4–7.

  16. Lo C, Cruces-moreno MT, Prieto-gonza S, Gil J, Fonseca-aizpuru E, Lo M, et al. IgG4-Related Disease: Results From a Multicenter Spanish Registry. 2015;94(32):1–5.

  17. Lin W, Lu S, Chen H, Wu Q, Fei Y, Li M, et al. Original ar ticle Clinical characteristics of immunoglobulin G4 related disease: a prospective study of 118 Chinese patients. 2015;(41):1982–90.

  18. Tomiyama F, Watanabe R, Fujii H, Kamogawa Y, Fujita Y, Shirota Y, et al. Synovitis in a Patient with IgG4-related Disease.Intern Med. 2015;54(11):1427–32.

  19. Sa H-S, Lee J-H, Woo KI, Kim Y-D. IgG4-related disease inidio pathic sclerosing orbital inflammation. Br J Ophthalmol. 2015;99(11):1493–7.

  20. Wallace ZS, Deshpande V, Stone JH. Ophthalmic manifestations of IgG4-related disease: Singlecenter experience and literature review. Semin Arthritis Rheum. 2014;43(6):806–17.

  21. Wu A, Andrew NH, McNab AA, Selva D. IgG4- Related Ophthalmic Disease: Pooling of Published Cases and Literature Review. Curr Allergy Asthma Rep. 2015;15(6):1–8.

  22. Wu A, Andrew NH, McNab AA, Selva D. Bilateral IgG4-related ophthalmic disease: a strong indication for systemic imaging. Br J Ophthalmol. 2015;307437.

  23. Goto H, Takahira M, Azumi A. Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol. 2014;1–7.

  24. Pieringer H, Parzer I, Wöhrer A, Reis P, Oppl B, Zwerina J. IgG4- related disease: an orphan disease with many faces. Orphanet J Rare Dis. 2014;9(1):110.

  25. Kakudo K, Li Y, Taniguchi E, Mori I, Ozaki T, Nishihara E, et al. IgG4-related disease of the thyroid glands. Endocr J. 2012;59(4):273–81.

  26. Deshpande V, Huck A, Ooi E, Stone JH, Faquin WC, Nielsen GP. Fibrosing variant of Hashimoto thyroiditis is an IgG4 related disease. J Clin Pathol. 2012;65(8):725–8.

  27. 27.Nishihara E, Hirokawa M, Ito M, Fukata S, Nakamura H, Amino N, et al. Graves' disease patients with persistent hyperthyroidism and diffuse lymphoplasmacytic infiltration in the thyroid show no histopathological compatibility with IgG4- related disease. PLoS One. 2015;10(7):1–9.

  28. Yamamoto M, Takahashi H, Ohara M, Suzuki C, Naishiro Y,Yamamoto H, et al. Anew conceptualization for Mikulicz's disease as an IgG4- related plasmacytic disease. Mod Rheumatol. 2006;16(6):335–40.

  29. Mavragani CP, Fragoulis GE, Rontogianni D, Kanariou M, Moutsopoulos HM. Elevated IgG4 serum levels among primary Sjögren's syndrome patients: do they unmask underlying IgG4-related disease? Arthritis Care Res( Hoboken ). 2014;66(5):773–7.

  30. Moteki H, Yasuo M, Hamano H, Uehara T, Usami S. IgG4-related chronic rhinosinusitis: a new clinical entityofnasal disease. Acta Otolaryngol. 2011;131(5):518–26.

  31. Yamashita H, Takahashi Y, Ishiura H, Kano T. Hypertrophic Pachymeningitis and Taheobronchial Stenosis in IgG4-related Disease: Case Presentation and Literature Review. 2011;935–41.

  32. Peikert T, Shrestha B, Aubry MC, Colby T V., Ryu JH, Sekiguchi H, et al. Histopathologic overlap between fibrosing mediastinitis and IgG4-related disease. Int J Rheumatol. 2012;2012. 33.Takagi D, Nakamaru Y, Fukuda S. Otologic manifestations of immunoglobulin g4-related disease. AnnOto lRhinolLar yngol. 2014;123(6):420–4.

  33. Lu LX, Della-Torre E, Stone JH, Clark SW. IgG4- Related Hypertrophic Pachymeningitis. JAMA Neurol. 2014;71(6):785.

  34. Schiffenbauer AI, Wahl C, Pittaluga S, Jaffe ES, Hoffman R, Khosroshahi A, et al. IgG4-related disease presenting as recurrent mastoiditis. Laryngoscope. 2012;122(3):681–4.

  35. Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, et al. A nationwide survey of hypertrophic pachymeningitis in Japan. J Neurol Neurosurg Psychiatry. 2014;85(7):732–9.

  36. Della-Torre E, Galli L, Franciotta D, Bozzolo EP, Briani C, Furlan R, et al. Diagnostic value of IgG4 Indicesin IgG 4 - Related Hypertrophic Pachymeningitis. J Neuroimmunol. 2014;266(1- 2):82–6.

  37. Inoue D, Zen Y, Sato Y, Abo H, Demachi H, Uchiyama A, et al. IgG4-related perineural disease. Int J Rheumatol. 2012;2012.

  38. Ohyama K, Koike H, Iijima M, Hashimoto R, Tomita M, Kawagashira Y, et al. IgG4-related neuropathy : acasereport. JAMAN eurol. 2013;70(4):502–5.

  39. Leporati P, Landek-Salgado MA, Lupi I, Chiovato L, Caturegli P. IgG4-related hypophysitis: A new addition to the hypophysitis spectrum. In: Journal of Clinical Endocrinology and Metabolism. 2011. p. 1971–80.

  40. Sosa GA, Bell S, Christiansen SB, Pietrani M, Glerean M, Loto M, et al. Histologically confirmed isolated IgG4-related hypophysitis: two case reports in young women. Endocrinol Diabetes Metab Case Reports. 2014;2014:140062.

  41. Sakai T, Kondo M, Yoshii S, Tomimoto H. IgG4- related disease that presented cranial, cervical, lumbar and sacral hypertrophic pachymeningitis associated with infundibulo-hypophysitis. Clin Neurol. 2014;54(8):664–7.

  42. Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, et al. The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature. Eur J Endocrinol. 2014;170(2):161–72.

  43. Cheuk W, Chan JKC. Lymphadenopathy of IgG4- relateddisease: Anunderdiagnosedand over diagnosed entity. Semin Diagn Pathol . 2012;29(4):226–34.

  44. Yanagi H, Yamazaki I, Shimizu S, Himeno H, Suzuki SI, Masuda M. Constrictive pericarditis caused by immunoglobulin G4-related disease. Ann Thorac Surg. 2014;97(3).

  45. Atallah PC, Kassier A, Powers S. IgG4-related disease with effusive-constrictive pericarditis, tamponade, and hepatopathy: A novel triad. Int J Cardiol; 2014;176(2):516–8.

  46. Hourai R, Miyamura M, Tasaki R, Iwata A, Takeda Y, Morita H, et al. A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis. Heart Vessels. Springer Japan; 2016;2–6.

  47. Tajima M, Nagai R, Hiroi Y. IgG4-Related Cardiovascular Disorders. 2014;4:287–95.

  48. Patel NR, Anzalone ML, Buja LM, Elghetany MT. Sudden cardiac death due to coronary artery involvement by IgG4-related disease: a rare, serious complication of a rare disease. Arch Pathol Lab Med. 2014;138(6):833–6.

  49. Winchester R, Bernstein DH, Fischer HD, Enlow R, Solomon G. The co-occurrence of Reiter's syndrome and acquired immunodeficiency. Ann Intern Med. 1987;106(1):19–26.

  50. Kouzu H, Miki T, Mizuno M, Kimura Y, Muranaka A, Yuda S, et al. Inflammatory myofibroblastic tumor of the heart. Overlap with IgG4-related disease? Circ J. 2014;78(4):1006–8.

  51. Song C, Koh MJ, Yoon YN, Joung B, Kim SH. IgG4-related sclerosing disease involving the superior vena cava and the atrial septum of the heart. Yonsei Med J. 2013;54(5):1285–8.

  52. Zen Y, Kasashima S, Inoue D. Retroperitoneal and aortic manifestations of immunoglobulin G4-related disease. Semin Diagn Pathol; 2012;29(4):212–8.

  53. Inoue D, Zen Y, Abo H, Gabata T, Demachi H, Kobayashi T, et al. Immunoglobulin G4-related lung disease: CT findings with pathologic correlations. Radiology. 2009;251(1):260–70.

  54. Choi IH, Jang SH, Lee S, Han J, Kim TS, Chung MP. A case report of IgG4-related disease clinically mimicking pleural mesothelioma. Tuberc Respir Dis (Seoul). 2014;76(1):42–5.

  55. Bhagat P, Bal A, Das A, Singh N, Singh H. Pulmonary inflammatory myofibroblastic tumor and IgG4-related inflammatory pseudotumor: Adiagnostic dilemma. Virchows Arch. 2013;463(6):743–7.

  56. Goag EK, Park JE, Lee EH, Park YM, Kim CY, Lee JM, et al. A case of extensive IgG4-related disease presenting as massive pleural effusion, mediastinal mass, and mesenteric lymphadenopathy in a 16-yearo ldmale. Tuberc Respir Dis (Seoul) . 2015;78(4):396–400.

  57. Martínez-de-Alegría A, Baleato-González S, García-Figueiras R, Bermúdez-Naveira A, et al. IgG4 - related Diseasefrom Headto Toe. RadioGraphics. 2015;35(7):2007–25.

  58. Matsui S, Yamamoto H, Minamoto S, Waseda Y, Mishima M, Kubo K. Proposed diagnostic criteria for IgG4-related respiratory disease. Respir Investig. 2016;54(2):130–2.

  59. Hart PA, Zen Y, Chari ST. Recent Advances in Autoimmune Pancreatitis. Gastroenterology. 2015;149(1):39–51.

  60. Al Zahrani H, Kyoung Kim T, Khalili K, Vlachou P, Yu H, Jang HJ. IgG4-related disease in the abdomen: A great mimicker. Semin Ultrasound, CT MRI. 2014;35(3):240–54.

  61. Sahani D V, Kalva SP, Farrell J, Maher MM, Saini S, Mueller PR, et al. Autoimmune pancreatitis: imaging features. Radiology. 2004;233(2):345–52.

  62. Shimosegawa T, Chari ST, Frulloni L, Kamisawa T, Kawa S, Mino-Kenudson M, et al. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancrea tology. Pancreas. 2011;40(3):352–8.

  63. Zen Y, Kawakami H, Kim JH. IgG4-related sclerosing cholangitis: all we need to know. J Gastroenterol; 2016;

  64. Perricone G. Hepatic involvement in IgG4-related disease: IgG4-hepatopathy and IgG4-autoimmune hepatitis. Autoimmun Rev. 2015;14(3):268–268.

  65. Zen Y, Fujii T, Sato Y, Masuda S, Nakanuma Y. Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease. Mod Pathol. 2007;20(8):884–94.

  66. Mulki R, Garg S, Manatsathit W, Miick R. IgG4- related inflammatory pseudotumour mimicking a hepatic abscess impending rupture. BMJ Case Rep. 2015;bcr2015211893.

  67. Yada N, Kudo M, Chung H, Watanabe T. Autoimmune hepatitis and immunoglobulin G4- associated autoimmune he patitis. Dig Dis. 2013;31(5-6):415–20.

  68. Woo CG. IgG4-Related Disease Presented as a Mural Mass in the Stomach. 2015;1:1–10.

  69. Avincsal MO, Otani K, Kanzawa M, Fujikura K, Jimbo N, Morinaga Y, et al. Sclerosing mesenteritis: A real manifestation or histological mimic of IgG4- related disease? Pathol Int. 2016;(1):n/a – n/a.

  70. Baltar-mar tín JM, García-monteavaro C, Manzanos TV, Parejo-garcía L. Afectación renal de las enfermdades relacionadas con IgG4 . 2015;7:1–10.

  71. Seo N, Kim JH, Byun JH, Lee SS, Kim HJ, Lee MG. Immunoglobulin G4-related kidney disease: A comprehensive pictorial review of the imaging spectrum, mimickers, and clinicopathological characteristics. Korean J Radiol. 2015;16(5):1056–67.

  72. Terumi Kamisawa, Yoh Zen, Shiv Pillai JHS. IgG4- Related Disease. Lancet. 2014;94(15):e680.

  73. Pradhan D, Pattnaik N, Silowash R, Mohanty SK. IgG4-related kidney disease - A review. Pathol Res Pract. Elsevier GmbH.; 2015;211(10):707–11.

  74. Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol. 2011;15(5):615–26.

  75. Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol. 2011;23(1):88–94.

  76. Hart P a., Smyrk TC, Chari ST. IgG4-related prostatitis: A rare cause of steroid-responsive obstr uctive urinar y symptoms. Int J Urol. 2013;20(1):132–4.

  77. Bourlon MT, Sanchez-Avila M, Chable-Montero F, Arceo-Olaiz R. IgG4-Related Autoimmune Prostatitis: Is It an Unusual or Underdiagnosed Manifestation of IgG4-Related Disease? Case Rep Urol. 2013;2013:295472.

  78. Sato Y, Takeuchi M, Takata K, Ohno K, Iwaki N, Orita Y, et al. Clinicopathologic analysis of IgG4- related skin disease. Mod Pathol. Nature Publishing Group; 2013;26(4):523–32.

  79. Lowe GC, Bogner RR, el-Azhary RA, Gonzalez- Santiago TM, Kindle SA, Lehman JS, et al. Cutaneous manifestations of immunoglobulin G4- related disease: What dermatologists need to know. Int J Dermatol. 2015;54(4):377–82.

  80. Iwata Y, Mizoguchi Y, Takahashi M, Tanaka B, Kuroda M, Yagami A, et al. Case of immunoglobulin G4-related skin disease: Possible immunoglobulin G4-related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis. J Dermatol. 2013;40(12):998–1003.

  81. Tokura Y, Yagi H, Yanaguchi H, Majima Y, Kasuya A, Ito T, et al. IgG4-related skin disease. Br J Dermatol. 2014;171(5):959–67.

  82. Cheuk W, Chan ACL, Lam W-L, Chow S-M, Crowley P, Lloydd R, et al. IgG4-related sclerosing mastitis: description of a new member of the IgG4- related sclerosing diseases. Am J Surg Pathol. 2009;33(7):1058–64.

  83. Bianchi D. IgG4-related disease: what urologists should know. Int Urol Nephrol.; 2016;

  84. Maruyama S, Sato Y, Taga A, Emoto I, Shirase T, Haga H. Immunoglobulin G4-related disease presenting as bilateral ovarian masses and mimicking advanced ovarian cancer. J Obstet Gynaecol Res. 2015;1–6.

  85. Della Torre E, Mattoo H, Mahajan VS, Carruthers M, Pillai S, Stone JH. Prevalence of atopy, eosinophilia, and IgE elevation in IgG4-related disease. Allergy Eur J Allergy Clin Immunol. 2014;69(2):269–72.

  86. Hirano K, Tada M, Sasahira N, Isayama H, Mizuno S, Takagi K, et al. Incidence of malignancies in patients with IgG4-related disease. Intern Med. 2014;53(3):171–6.

  87. Stone JH, Brito-Zer??n P, Bosch X, Ramos-Casals M. Diagnostic Approach to the Complexity of IgG4- Related Disease. Mayo Clinic Proceedings. 2015. p. 927–39.

  88. Alejandro D, Oostdam H Van, Jaimes T, Martínezmartínez MU, Oros-ovalle C, Abud-mendoza NAC. Enfermedades relacionadas con IgG4 , diagnóstico histopatológico retrospectivo. Prevalencia en un hospital universitario. 2015;11(6):335–9.

  89. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181–92.

  90. Khosroshahi A, Wallace ZS, Crowe JL, Akamizu T, Azumi A, Carruthers MN, et al. International Consensus Guidance Statement on the Management and Treatmento fIgG4 - Related Disease. 2015;67(7):1688–99.

  91. Wallace ZS, Mattoo H, Carruthers M, Mahajan VS, Della Torre E, Lee H, et al. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations. Ann Rheum Dis. 2014;74(1):1–6.

  92. Zhang J, Chen H, Ma Y, Xiao Y. Characterizing IgG4-related disease with 18 F-FDG PET / CT: a prospective cohort study. 2014;1624–34.

  93. Fujinaga Y, Kadoya M, Kawa S, Hamano H, Ueda K, Momose M, et al. Characteristic findings in images of extra-pancreatic lesions associated with autoimmune pancreatitis. Eur J Radiol;2010;76(2):228–38.

  94. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4- RD), 2011. Mod Rheumatol. 2012;22(1):21–30.

  95. Carruthers MN, Topazian MD, Khosroshahi A, Witzig TE, Wallace ZS, Hart PA, et al. Rituximab for IgG4-related disease: a prospective ,. 2015;1171–7.

  96. Carr uthers MN, Stone JH, Deshpande V, Khosroshahi A. Development of an IgG4-RD responder index. Int J Rheumatol. 2012;2012.




2020     |     www.medigraphic.com