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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2005, Número 2

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Rev Invest Clin 2005; 57 (2)


Perspectivas de las células tallo en infartos del miocardio

Aceves JL, Archundia A, Díaz G, Páez A, Masso F, Alvarado M, López HM, Aceves R, Puente A, Vilchis R, Montaño LF

Idioma: Español
Referencias bibliográficas: 77
Paginas: 156-162
Archivo PDF: 73.88 Kb.


RESUMEN

El infarto del miocardio es la principal causa de falla cardiaca y muerte en países industrializados. A la fecha, la cardiomioplastia celular ha emergido como una alternativa en la regeneración de infartos miocárdicos. En modelos animales se han utilizado diferentes líneas celulares como cardiomiocitos fetales, mioblastos de músculo esquelético, células tallo embrionarias y células tallo mesenquimales del adulto, con mejoría en la función ventricular y disminución del área de tejido infartado. Las tres primeras líneas celulares tienen desventajas porque son alogénicas y difíciles de obtener. Las células tallo mesenquimales del adulto son autólogas y se pueden obtener de aspirados de médula ósea o de la circulación periférica previa estimulación con citocinas (G-CSF). La implantación de estas células en seres humanos con infartos del miocardio recientes y antiguos han mostrado mejorías similares a los reportes con modelos animales. Estos hallazgos alientan a continuar la investigación clínica y básica en busca de los mecanismos de diferenciación celular y selección de vías de implantación, en tejido miocárdico infartado.


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