Reyes-García MG, Robles-Martínez S, García TF

Idioma: Español
Referencias bibliográficas: 29
Paginas: 5-9
Archivo PDF: 54.99 Kb.

RESUMEN

El timo es un órgano esencial del sistema inmune que recibe los linfocitos T inmaduros que proceden de la médula ósea y se ocupa de eliminar aquellos defectuosos y auto-reactivos, al mismo tiempo que estimula la maduración de los restantes, principalmente los linfocitos T colaboradores y reguladores. Las células nodrizas del timo son células epiteliales que endocitan los linfocitos T inmaduros mediante la invaginación de la membrana y los conservan en vacuolas que expresan tanto caveolinas como moléculas Clase II del MHC. Es probable que las selecciones positiva y negativa de los linfocitos T inmaduros dependan del reconocimiento de esos antígenos, unidos o no a péptidos propios. El proceso de la maduración y selección de los linfocitos T dentro del timo se encuentra modulado por los sistemas nerviosos central y vegetativo. Algunas enfermedades por hipersensibilidad mediadas por linfocitos T pueden tener su origen en un desbalance de esa modulación y/o un trabajo deficiente de sus células nodrizas.

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