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ISSN 0016-3813 (Impreso)

2015, Número 4

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Gac Med Mex 2015; 151 (4)


Terapia génica para enfermedades hereditarias oftalmológicas: avances y perspectivas

Chacón-Camacho ÓF, Astorga-Carballo A, Zenteno JC

Idioma: Español
Referencias bibliográficas: 86
Paginas: 501-511
Archivo PDF: 316.78 Kb.


RESUMEN

La terapia génica es una estrategia terapéutica novedosa y prometedora que podría proporcionar una forma más efectiva para tratar las enfermedades. El ojo es un órgano fácilmente accesible, altamente compartimentado y con privilegio inmunológico, los cuales proporcionan la ventaja para que sea un blanco terapéutico ideal. Recientemente se han descrito avances importantes en la disponibilidad de diversas vías intraoculares para la liberación de los vectores virales, así como la capacidad de éstos para transducir algunos tipos de células oculares específicas. La terapia génica ha avanzado en algunas distrofias retinianas; de esta forma, se ha reportado actualmente un éxito preliminar para el tratamiento de la amaurosis congénita de Leber (LCA). Esta revisión describirá una actualización en el área de la terapia génica para el tratamiento de las enfermedades hereditarias oftalmológicas.


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