2002, Número 2
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Rev Mex Patol Clin Med Lab 2002; 49 (2)
Conexiones neuroendocrinoinmunológicas
Batista DA
Idioma: Español
Referencias bibliográficas: 42
Paginas: 85-91
Archivo PDF: 188.34 Kb.
RESUMEN
Neuroendocrinoinmunología constituye un nuevo campo de investigación con un desarrollo acelerado, que cada vez gana más el interés entre grupos de investigación y médicos debido a que se ha ido descubriendo un número apreciable de fenómenos moleculares que sirven de base para explicar múltiples estados fisiológicos y patológicos cuyos mecanismos eran desconocidos, por lo que se dificultaba trazar estrategias novedosas con fines diagnósticos y terapéuticos. La descripción de las interacciones entre los sistemas nervioso, endocrino e inmune ha permitido comprender mejor los efectos orgánicos inducidos por el estrés, los eventos fisiológicos y patológicos que ocurren en el tracto digestivo, la fisiopatología de la respuesta de fase aguda y la patogenia de múltiples enfermedades neurológicas, entre otras entidades. El objetivo de este trabajo es informar sobre el conocimiento actual de algunas de las principales vías de integración entre estos tres importantes sistemas y discutir las nuevas tendencias hacia donde se dirigen las investigaciones en este campo.
REFERENCIAS (EN ESTE ARTÍCULO)
Solomon GF. Emotions, stress, the nervous system and immunity. Ann New York Acad Sci 1969, 164: 335–343.
Ader R, Felten D, Cohen N. Interactions between the brain and the immune system. Ann Rev Pharmacol Toxicol 1990; 30: 561–602.
Pruett SB, Collier S, Wu WS, Fan R. Quantitative relationship between the suppression of selected immunological parameters and the area under the corticosterone concentration vs time curve in B6C3 F1 mice subjected to exogenous corticosterone or to restraint stress. Toxicol Sci 1999; 49: 272–280.
Redwine LS, Altemus M, Leong VM, Carter CS. Lymphocyte responses to stress in postpartum women: Relationship to vagal tone. Psychoneuroendocrinology 2001; 26: 241–251.
Pruett SB. Quantitative aspects of stress-induced immunomodulation. Int Immunopharmacol 2001; 1 (3): 507-520.
Theodorou V, Floramonti S, Bueno L. Integrative neuroimmunology of the digestive tract. Vet Res 1996; 27: 427-442.
Ottaway CA. Neuroimmunomodulation in the intestinal mucosa. Gastroenterol Clin N Am 1991; 20: 511–529.
Steel DM, Whitehead AS. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today 1994; 15: 81–88.
Sternberg EM. Neuroendocrine factors in susceptibility to inflammatory disease: Focus on the hypothalamic-pituitary-adrenal axis. Horm Res 1995; 43: 159–161.
O’Connor KC, Bar-Or A, Hafler DA. The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J Clin Immunol 2001; 21 (2): 81-92.
Baraczka K, Nekam K, Pozsonyi T, Jakab L, Szongoth M, Sesztak M. Concentration of soluble adhesion molecules (sVCAM-1, sICAM-1 and sL-Selectin) in the cerebrospinal fluid and serum of patients with multiple sclerosis and systemic lupus erythematosus with central nervous involvement. Neuroimmunomodulation 2001; 9 (1): 49-54.
Huang YM, Stoyanova N, Jin YP, Teleshova N, Hussien Y, Xiao BG, Fredrikson S, Link H. Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-beta and IL-10. Clin Exp Immunol 2001; 124 (2): 306-314.
Savino W, Dardenne M. Immune-neuroendocrine interactions. Immunol Today 1995; 16 (5): 318-322.
Turrin NP, Plata Salaman CR. Cytokine-cytokine interactions and the brain. Brain Res Bull 2000; 51: 3-9.
Szelenyi J. Cytokines and the central nervous system. Brain Res Bull 2001; 54 (4): 329-338.
Bullock K. The innervation of immune system tissues and organ. In: Cotman CW, Brinton RE, Galaborda A, Mc Ewen B, Schneider DM (eds). The neuro-immune-endocrine connection. New York: Raven Press, 1987: 33.
Felten DL, Felten SY, Bellinger DL, Carlson SL, Ackerman KD, Madden KS, Olschowka JA, Livnat S. Noradrenergic sympathetic neural interaction with the immune system: Structure and function. Immunol Rev 1987; 100: 225-231.
Schuurman HJ, Kuper FC, Vos JG. Histopathology of the immune system as a tool to assess immunotoxicity. Toxicology 1994; 86: 187-192.
Wilckens T, De Rijk R. Glucocorticoids and the immune function unknown dimensions and the new frontiers. Immunol Today 1997; 18 (9): 418-424.
Mc Conkey DJ, Nocotera P, Hartzell P, Bellomo G, Wyllie AH, Orrenius S. Glucocorticosteroids activate a suicide process in thymocytes through an elevation of cytosolic Ca+2 concentrations. Arch Biochem Biophys 1989; 269: 365–370.
Schuurman HJ, Kuper F. Pathology of the thymus. Changes induced by xenobiotics and the gene targeting. APMIS 1995; 103: 481-500.
Fahey JL. Environmental exposures: psychological stress. Hum Exp Toxicol 1995; 14: 92-94.
Pruett SB, Fan R, Myers P, Wu WS, Collier S. Quantitative analysis of the neuroendocrine-immune axis: linear modeling of the effects of exogenous corticosterone and restrain stress on lymphocyte subpopulations in the spleen and the thymus in female B6C3F1 mice. Brain Behavior Immunity 2000; 14: 270–287.
Lai JP, Ho WZ, Zhan GX, Yi Y, Collman RG, Douglas SD. Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes. Proc Natl Acad Sci USA 2001; 98 (7): 3970-3975.
Hanesch U. Neuropeptides in dural fine sensory nerve endings-involvement in neurogenic inflammation? Prog Brain Res 1996; 113: 299-317.
Kimata H, Fujimoto M. Vasoactive intestinal peptide specifically induces human IgA1 and IgA2. Eur J Immunol 1994; 24: 2262–2265.
Matera L, Mori M, Geuna M, Buttiglieri S, Palestro G. Prolactin in autoimmunity and antitumor defense. J Neuroimmunol 2000; 109 (1): 47-55.
Clarke AG. Immunological studies on pregnancy in the mouse In: Crighton DB (ed). Immunological aspects of reproduction in mammals. London: Butterworths, 1984.
Clarke AG, Kendall MD. Histological changes in the thymus during mouse pregnancy. Thymus 1989; 14: 65-68.
Kendall MD, Fitzpatrick FTA, Greenstein BD, Khoylou F, Safieh B, Hamblin A. Reversal of ageing changes in the thymus of rats by chemical or surgical castration. Cell Tissue Res 1990; 261: 555-560.
Greenstein BD, Fitzpatrick FTA, Kendall MD, Wheeler MJ. Regeneration of the thymus in old male rats treated with a stable analogue of LHRH. J Endocrinol 1987; 112: 345–351.
Wegmann TG, Lin H, Guilbert LJ, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14: 353-356.
Piccinni MP, Giudizi MG, Biagiotti R. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995; 155: 128-131.
Kuhlwein E, Irwin M. Melatonin modulation of lymphocyte proliferation and Th1/Th2 cytokine expression. J Neuroimmunol 2000; 117 (1-2): 51-57.
Cardinalli DP, Cutrera RA, Bonacho MG, Esquifino AI. Effect of pinealectomy, superior cervical ganglionectomy, or melatonin treatment on 24-hour rhythms in ornithine decarboxylase and tyrosine hydroxylase activities of rat spleen. J Pineal Res 1997; 22 (4): 210-220.
Mosmann T, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-2357.
Romagnani S. Understanding the role of Th1/Th2 cells in infections. T Microbiol 1996; 4 (12): 470-473.
Breder CD, Dinarello CA, Saper CB. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 1988; 240: 321-324.
Plata Salaman CR, Oomura Y, Kai Y. Tumor necrosis factor and interleukin-1 beta: suppression of food intake by direct actino in the central nervous system. Brain Res 1988; 448: 106-114.
Luheshi G, Rothwell N. Cytokines and fever. Int Arch Allergy Immunol 1996; 109: 301-307.
Dunn AJ, Swiergiel AH. The role of citokines in infection-related behavior. Ann N Y Acad Sci 1998; 840: 577-585.
Schijns VE. Induction and direction of immune responses by vaccine adjuvants. Cri Rev Imm 2001; 21: 75-85.