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2014, Número 2

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Rev Esp Cienc Salud 2014; 17 (2)


Metabolismo energético y cáncer

Valle MA, Soto CI

Idioma: Español
Referencias bibliográficas: 36
Paginas: 108-113
Archivo PDF: 416.71 Kb.


RESUMEN

Una de las características más importantes de muchos tipos de cáncer es que presentan un metabolismo alterado, tienden a captar más eficientemente la glucosa y aumenta la glucólisis y esta última está desacoplada del ciclo de Krebs y de la fosforilación oxidativa en mitocondria. La regulación del metabolismo energético es compleja, existen proteínas reguladoras como HIF (una proteína prometastásica), la cual disminuye el metabolismo oxidativo, mientras que p53 (supresor tumoral) promueve la fosforilación oxidativa. Estos datos nos indican que una de las posibles funciones primarias de los oncogenes activados y de los supresores de tumores inactivados es la reprogramación del metabolismo celular.


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