González-Duarte RJ, Cázares-Ordoñez V, Ávila-Chávez E

Idioma: Ingles.
Referencias bibliográficas: 35
Paginas: 460-464
Archivo PDF: 149.10 Kb.

RESUMEN

Los microRNAs son una clase de RNAs no codificantes que regulan la expresión génica en la etapa postranscripcional. Las principales proteínas de la vía canónica de biogénesis de los microRNAs en el humano son: Drosha, DGCR8, DDX5, DDX17, Exportina 5, Dicer y Argonauta 2. Estudios recientes sugieren que la expresión génica de algunos componentes de la biogénesis de los microRNAs podría ser blanco de las hormonas esteroideas. Por otro lado, diversas alteraciones en la biogénesis de los microRNAs han sido asociadas a padecimientos como el cáncer. Dada la importancia de los microRNAs en la fisiología celular, el estudio de los factores que regulan o afectan su biogénesis es fundamental.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Bartel DP. MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. Cell 2004; 116: 281-97.

2. Carthew R, Sontheimer E. Origins and mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-55.

3. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-54.

4. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403: 901-6.

5. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-33.

6. Finnegan EF, Pasquinelli AE. MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol 2013; 48: 51-68.

7. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19(1): 92-105.

8. Peterson SM, Thompson JA, Ufkin ML, Sathyanarayana P, Liaw L, Bates-Congdon C. Common features of microRNA target prediction tools. Front Genet 2014; 5: 1-10.

9. Xie M, Steitz JA. Versatile microRNA biogenesis in animals and their viruses. RNA Biology 2014; 11(6): 1-9.

10. Klinge CM. miRNAs and estrogen action. Trends Endocrinol Metab 2012; 23(5): 223-33.

11. Wang WL, Chatterjee N, Chittur SV, Welsh J, Tenniswood MP. Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer 2011; 10: 58.

12. Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, et al. Estradiol-regulated micro- RNAs control estradiol response in breast cancer cells. Nucleic Acids Res 2009; 37(14): 4850-61.

13. Nothnick WB, Healy C, Hong X. Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1. Endocr 2010; 37: 265-73.

14. Nothnick WB. Regulation of uterine matrix metalloproteinase- 9 and the role of microRNAs. Semin Reprod Med 2008; 26(6): 494-9.

15. Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, et al. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol 2007; 9: 604-11.

16. Wagner M, Rid R, Maier CJ, Maier RH, Laimer M, Hintner H, Bauer JW, Onder K. DDX5 is a multifunctional co-activator of steroid hormone receptors. Mol Cell Endocrinol 2012; 361(1- 2): 80-91.

17. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama K, et al. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell 2009; 36(2): 340-7.

18. Tsai-Morris CH, Sheng Y, Gutti RK, Tang PZ, Dufau ML. Gonadotropin- regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis. J Androl 2010; 31(1): 45-52.

19. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435(7043): 834-8.

20. Jansson MD, Lund AH. MicroRNA and cancer. Mol Oncol 2012; 6(6): 590-610.

21. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 2006; 20(16): 2202-7.

22. Zhang L, Huang J, Yang N, Greshock J, Megraw MS, Giannakakis A, Liang S, et al. microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA 2006; 103(24): 9136-41.

23. Kim MS, Oh JE, Kim YR, Park SW, Kang MR, Kim SS, Ahn CH, et al. Somatic mutations and losses of expression of micro- RNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. J Pathol 2010; 221(2): 139-46.

24. Kitagawa N, Ojima H, Shirakihara T, Shimizu H, Kokubu A, Urushidate T, Totoki Y, et al. Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. Cancer Sci 2013; 104(5): 543-51.

25. Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 2007; 39(5): 673-7.

26. Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 2008; 359(25): 2641-50.

27. Guo X, Liao Q, Chen P, Li X, Xiong W, Ma J, Li X, et al. The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma. J Cancer Res Clin Oncol 2012; 138(1): 49-56.

28. He L, Wang HY, Zhang L, Huang L, Li JD, Xiong Y, Zhang MY, et al. Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer. Cell Death Dis 2014; 1(5): e1205.

29. Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, et al. A microRNA targeting Dicer for metastasis control. Cell 2010; 141(7): 1195-207.

30. Fuller-Pace F, Moore H. RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development. Future Oncology 2011; 7(2): 239-51.

31. Paris O, Ferraro L, Grober OM, Ravo M, De Filippo MR, Giurato G, Nassa G, Tarallo R, et al. Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer. Oncogene 2012; 31(38): 4196-206.

32. van Kouwenhove M, Kedde M, Agami R. MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer 2011; 11(9): 644-56.

33. Díaz-García CV, Agudo-López A, Pérez C, López-Martín JA, Rodríguez-Peralto JL, de Castro J, Cortijo A, et al. DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification. Carcinogenesis 2013; 34(5): 1031-8.

34. De Santa F, Iouse I, Del Rio A, Fazi F. microRNA Biogenesis Pathway as a Therapeutic Target for Human Disease and Cancer. Curr Pharm Des 2013; 19(4): 745-64.

35. Havens MA, Reich AA, Duelli DM, Hastings ML. Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res 2012; 40(10): 4626-40.